A5100770250- Genetics, Aging, and Longevity in Model Organisms
- Ubiquitin and proteasome pathways
- Lipid metabolism and biosynthesis
- Cellular transport and secretion
- Autophagy in Disease and Therapy
- Circadian rhythm and melatonin
- Endoplasmic Reticulum Stress and Disease
- Axon Guidance and Neuronal Signaling
- Photosynthetic Processes and Mechanisms
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Microtubule and mitosis dynamics
- Heat shock proteins research
- Cancer, Hypoxia, and Metabolism
- Molecular Biology Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Reproductive Biology and Fertility
- Traditional Chinese Medicine Studies
- Genetics and Neurodevelopmental Disorders
- Nerve injury and regeneration
- Forensic and Genetic Research
- Skin and Cellular Biology Research
- Nuclear Structure and Function
- Plant tissue culture and regeneration
Anhui Agricultural University
2025
Chinese Academy of Sciences
2015-2024
University of Chinese Academy of Sciences
2018-2024
Institute of Genetics and Developmental Biology
2015-2024
Institute of Biophysics
2024
China Medical University
2013-2020
Center for Excellence in Brain Science and Intelligence Technology
2015-2018
Anhui University
2014-2016
Institute of Zoology
2014
Jilin University
2014
Stereotyped synaptic connectivity can arise both by precise recognition between appropriate partners during synaptogenesis and selective synapse elimination. The molecular mechanisms that underlie removal are largely unknown. We found stereotyped developmental elimination of synapses in the Caenorhabditis elegans hermaphrodite-specific motor neuron (HSNL) was mediated an E3 ubiquitin ligase, a Skp1-cullin-F-box (SCF) complex composed SKR-1 F-box protein SEL-10. SYG-1, adhesion molecule,...
One of the challenges to understand organization nervous system has been determine how axon guidance molecules govern outgrowth. Through an unbiased genetic screen, we identified a conserved Wnt pathway which is crucial for anterior-posterior (A/P) outgrowth neurites from RME head motor neurons in Caenorhabditis elegans. The composed ligand CWN-2, Frizzled receptors CFZ-2 and MIG-1, co-receptor CAM-1/Ror, downstream component Dishevelled/DSH-1. Among these, CWN-2 acts as local attractive cue...
Hydrogen sulfide (H2S) plays a crucial role in regulating plant development and stress responses. Here, the potential of H2S enhancing cadmium (Cd) tolerance by modulating antioxidant defense system reactive oxygen species (ROS) homeostasis was investigated. The results shown that Cd (II) exposure significantly inhibited growth chlorophyll content rapeseed seedlings. Optimal exogenous sodium hydrosulfide (NaHS; 50 μM) pretreatment markedly alleviated Cd-induced inhibition, chlorosis, root...
The C. elegans genome encodes a single Eph receptor tyrosine kinase, VAB-1, which functions in neurons to control epidermal morphogenesis. Four members of the ephrin family ligands for receptors have been identified elegans. Three ephrins (EFN-1/VAB-2, EFN-2 and EFN-3) previously shown function VAB-1 signaling. We show that mutations gene mab-26 affect fourth elegansephrin, EFN-4. efn-4 also embryonic morphogenesis, it is expressed developing nervous system. Interestingly, display...
Elongation of the epidermis nematode Caenorhabditis elegansinvolves both actomyosin-mediated changes in lateral epidermal cell shape and body muscle attachment to dorsal ventral cells via intermediate-filament/hemidesmosome structures. vab-19 mutants are defective elongation epidermis. VAB-19 is a member conserved family ankyrin repeat-containing proteins that includes human tumor suppressor Kank. In cells,VAB-19::GFP localizes with components mutants, structures form normally but do not...
Phosphatidylserine (PS), synthesized in the endoplasmic reticulum (ER) by phosphatidylserine synthase (PSS), is transported to plasma membrane (PM) and mitochondria through distinct routes. The vivo functions of PS at different subcellular locations coordination between transport routes are not fully understood. Here, we report that Drosophila PSS regulates cell growth, lipid storage mitochondrial function. In pss RNAi, reduced depletes Akt, contributing growth defects; metabolic shift from...
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of pathologies, ranging from steatosis to nonalcoholic steatohepatitis (NASH). The factors promoting the progression NASH are still unclear. Recent studies suggest that mitochondrial lipid composition is critical in development. Here, we showed CDP-DAG synthase 2 (Cds2) was downregulated genetic or diet-induced NAFLD mouse models. Liver-specific deficiency Cds2 provoked hepatic steatosis, inflammation and fibrosis five-week-old...
The UNC-104/KIF1A motor is crucial for axonal transport of synaptic vesicles, but how the activated in vivo not fully understood. Here, we identified point mutations located domain or inhibitory CC1 domain, which resulted gain-of-function alleles unc-104 that exhibit hyperactive and abnormal accumulation vesicles. In contrast to cell body localization wild type motor, mutant motors accumulate on neuronal processes. Once process, display dynamic movement similarly motors. mutation leads an...
Lipid storage in fat tissue is important for energy homeostasis and cellular functions. Through RNAi screening Drosophila body, we found that knockdown of a NAD kinase (NADK), which phosphorylates to synthesize NADP de novo, causes lipid defects. NADK sustains lipogenesis by maintaining the pool NADPH. Promoting NADPH production rescues defect body animals. Furthermore, fatty acid synthase 1 (FASN1) regulate mitochondrial mass function altering levels acetyl-CoA acids. Reducing level or...
Abstract The SAD/BRSK kinases participate in various important life processes, including neural development, cell cycle and energy metabolism. Like other members of the AMPK family, SAD contains an N-terminal kinase domain followed by characteristic UBA KA1 domains. Here we identify a unique autoinhibitory sequence (AIS) kinases, which exerts autoregulation cooperation with UBA. Structural studies mouse SAD-A revealed that binds to distinct mode and, more importantly, AIS nestles...
Xuezhikang (XZK), an extract of red yeast rice, has been widely used for the management hyperlipidemia and coronary heart disease (CHD); however, effects XZK treatment on kidney injury have not yet fully identified. The aim current study was to evaluate kidneys investigate related mechanisms in a rat model hyperlipidemia. Thus, effect inflammatory transcription factors damage investigated with vitro vivo experiments hyperlipidemic rats following treatment. results revealed that plasma levels...
Pyrroloquinoline quinone (PQQ) has been shown to protect primary cultured hippocampal neurons from glutamateinduced cell apoptosis by scavenging reactive oxygen species (ROS) and activating phosphatidylinositol-3-kinase (PI3K)/Akt signaling.We investigated the downstream pathways of PI3K/Akt involved in PQQ protection glutamate-injured neurons.Western blot analysis indicated that treatment following glutamate stimulation triggers phosphorylation glycogen synthase kinase 3β, accompanied...
Electrical synaptic transmission through gap junctions is a vital mode of intercellular communication in the nervous system. The mechanism by which reciprocal target cells find each other during formation junctions, however, poorly understood. Here we show that are formed between BDU interneurons and PLM mechanoreceptors C. elegans connectivity with influenced Wnt signaling. We further identified two PAS-bHLH family transcription factors, AHA-1 AHR-1, function cell-autonomously within to...