A5016670913- Neurobiology and Insect Physiology Research
- Signaling Pathways in Disease
- Cellular transport and secretion
- Nerve injury and regeneration
- Angiogenesis and VEGF in Cancer
- COVID-19 and healthcare impacts
- Microtubule and mitosis dynamics
- Plant Reproductive Biology
- Protease and Inhibitor Mechanisms
- Immune responses and vaccinations
- Long-Term Effects of COVID-19
- Acute Myeloid Leukemia Research
- Bone and Joint Diseases
- Ubiquitin and proteasome pathways
- Effects and risks of endocrine disrupting chemicals
- Pluripotent Stem Cells Research
- Hematological disorders and diagnostics
- Developmental Biology and Gene Regulation
- COVID-19 Clinical Research Studies
- Silk-based biomaterials and applications
- COVID-19 Digital Contact Tracing
- Immunodeficiency and Autoimmune Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Photosynthetic Processes and Mechanisms
- COVID-19 epidemiological studies
Pennsylvania State University
2016-2022
Penn State Milton S. Hershey Medical Center
2020-2022
Hershey (United States)
2020
Wilkes University
2009-2016
Commonwealth Medical College
2009-2016
University of South Alabama
1998
Dendrite microtubules are polarized with minus-end-out orientation in Drosophila neurons. Nucleation sites concentrate at dendrite branch points, but how they localize is not known. Using Drosophila, we found that canonical Wnt signaling proteins regulate localization of the core nucleation protein γTubulin (γTub). Reduction frizzleds (fz), arrow (low-density lipoprotein receptor-related [LRP] 5/6), dishevelled (dsh), casein kinase Iγ, G proteins, and Axin reduced γTub-green fluorescent...
While many regulators of axon regeneration have been identified, very little is known about mechanisms that allow dendrites to regenerate after injury. Using a Drosophila model dendrite regeneration, we performed candidate screen receptor tyrosine kinases (RTKs) and found requirement for RTK-like orphan (Ror). We confirmed Ror was required in two different neuron types using RNA interference (RNAi) mutants. not or normal development, suggesting specific role regeneration. can act as Wnt...
Kinetochores connect centromeric chromatin to spindle microtubules during mitosis. Neurons are postmitotic, so it was surprising identify transcripts of structural kinetochore (KT) proteins and regulatory chromosome passenger complex (CPC) assembly checkpoint (SAC) in Drosophila neurons after dendrite injury. To test whether these function regeneration, postmitotic RNA interference (RNAi) performed dendrites or axons were removed using laser microsurgery. Reduction KT, CPC, SAC decreased...
Axon injury can lead to several cell survival responses including increased stability and axon regeneration. Using an accessible Drosophila model system, we investigated the regulation of their relationship. stabilizes rest cell, entire dendrite arbor. After found mitochondrial fission in dendrites was upregulated, that reducing stabilization or neuroprotection (NP). Thus seems both turn on NP, but also dampen it by activating fission. We identified caspases as negative regulators...
The degeneration of injured axons involves a self-destruction pathway whose components and mechanism are not fully understood. Here, we report new regulator axonal resilience. transmembrane protein Raw is cell autonomously required for the axons, dendrites, synapses in Drosophila melanogaster . In both male female raw hypomorphic mutant or knock-down larvae, from motoneurons sensory neurons strongly inhibited. This protection insensitive to reduction levels NAD + synthesis enzyme Nmnat...
Phthalates are a group of plasticizers that widely used in many consumer products and medical devices, thus generating huge burden to human health. have been known cause number developmental reproductive disorders functioning as endocrine modulators. They also involved carcinogenesis with mechanisms less understood. To further understand the molecular phthalate toxicity, this study we reported new effect phthalates on mRNA translation/protein synthesis, key regulatory step gene expression....
Thrombospondin 1 (TSP1) is an antiangiogenic protein which induces endothelial cell death. As a major activator of the transforming growth factor beta (TGFβ1), TSP1 effective regulator immune response. Recently, we reported that mice deficient in (TSP1-/-) showed more severe inflammation and enhanced angiogenesis murine model for colitis. (1,2) Interleukin 6 (IL6) cytokine involved variety inflammatory processes including bowel disease (IBD) cancer. In this study, investigate whether IL6...
Thrombospondin‐1 (TSP‐1) is the first identified endogenous inhibitor of angiogenesis; it has been demonstrated to regulate colon cancer development in a colitis‐associated mouse model. Here, we reported for time that TSP‐1 down‐regulated expression HSP90α. knock‐out mice (TSP‐1 −/− ) showed no difference at HSP90α level with wild type (WT) under normal and mild inflamed conditions, but expressed elevated stage induced by DSS/AOM complicated pattern degradation cancerous lesion stage. The...