A5101821100- Metal complexes synthesis and properties
- Microtubule and mitosis dynamics
- melanin and skin pigmentation
- Cellular transport and secretion
- Traditional Chinese Medicine Analysis
- Cancer, Hypoxia, and Metabolism
- Sperm and Testicular Function
- Biochemical Analysis and Sensing Techniques
- Renal and related cancers
- Crystal structures of chemical compounds
- RNA Interference and Gene Delivery
- Cancer therapeutics and mechanisms
- Lanthanide and Transition Metal Complexes
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- Reproductive Biology and Fertility
- Cancer-related Molecular Pathways
- Gout, Hyperuricemia, Uric Acid
- Advanced Electron Microscopy Techniques and Applications
- Ginseng Biological Effects and Applications
- Autophagy in Disease and Therapy
- Retinal Development and Disorders
- Endoplasmic Reticulum Stress and Disease
- Magnetism in coordination complexes
- Cancer, Lipids, and Metabolism
Fujian Medical University
2019-2025
Chinese Academy of Sciences
2012-2024
Ministry of Water Resources of the People's Republic of China
2024
University of Chinese Academy of Sciences
2020-2024
Institute of Soil and Water Conservation
2024
Northwest A&F University
2024
China Pharmaceutical University
2016-2024
West China Medical Center of Sichuan University
2010-2024
Institute of Population, Health and Development
2024
West China Hospital of Sichuan University
2023
Recent developments in nanotechnology have provided researchers with new tools for cancer imaging and treatment. This technology has enabled the development of nanoscale devices that can be conjugated several functional molecules simultaneously, including tumor-specific ligands, antibodies, anticancer drugs, probes. Since these nanodevices are 100 to 1,000-fold smaller than cells, they easily transferred through leaky blood vessels interact targeted proteins both on surface inside cells....
Spermiogenesis is a complex and highly ordered spermatid differentiation process that requires reorganization of cellular structures. We have previously found Atg7 required for acrosome biogenesis. Here, we show autophagy regulates the round elongating spermatids. Specifically, spermatozoa flagella biogenesis cytoplasm removal during spermiogenesis. Spermatozoa motility atg7-null mice dropped significantly with some extra-cytoplasm retained on mature sperm head. These defects are associated...
Berberine, a natural product derived from plant used in Chinese herbal medicine, is reported to exhibit anticancer effects; however, its mechanism of action not clearly defined. Herein, we demonstrate that berberine induces apoptosis acute lymphoblastic leukemia (ALL) cells by downregulating the MDM2 oncoprotein. The proapoptotic effects were closely associated with both expression levels and p53 status set ALL cell lines. most potent was induced overexpression wild-type (wt)-p53, whereas no...
The ectoplasmic specialization (ES) is essential for Sertoli-germ cell communication to support all phases of germ development and maturity. Its formation remodeling requires rapid reorganization the cytoskeleton. However, molecular mechanism underlying regulation ES assembly still largely unknown. Here, we show that Sertoli cell-specific disruption autophagy influenced male mouse fertility due resulting disorganized seminiferous tubules spermatozoa with malformed heads. In...
Significance Genetic control of the differentiation between Sertoli cells and granulosa has been reported previously. However, relationship Leydig in testis not yet definitively determined. In present study, we demonstrate for first time, to our knowledge, that these two cell types can be mutually reprogrammed Wilms’ Tumor Gene 1 ( Wt1 ) plays a critical role this process. This study provides novel concept fate determination development will improve understanding regulatory mechanisms gonad...
Abstract Liver cancer is the second cause of death from worldwide, without effective treatment. Traditional chemotherapy for liver has big side effects patients, whereas targeted drugs, such as sorafenib, commonly have drug resistance. Oroxylin A (OA) main bioactive flavonoids Scutellariae radix, which strong anti-hepatoma effect but low toxicity to normal tissue. To date, no differentiation-inducing agents been reported exert a curative on solid tumors. Here our results demonstrated that OA...
Liang Zou1, Di Wang1, Yichen Hu2, Chaomei Fu3, Wei Li1, Liping Dai1, Lin Yang1 and Jinming Zhang3 1School of Medicine, Chengdu University, 610106, China 2College Pharmacy Biological Engineering, 3College Pharmacy, University Traditional Chinese 611137, Correspondence to: Yang, email: [email protected] Zhang, Keywords: MDR reversal, co-delivery, P-gp inhibition, PAMAM dendrimer, borneol Received: May 04, 2017 Accepted: June 10, Published: July 31, ABSTRACT Paclitaxel (PTX) is frequently...
This study constitutes the first example of antitumor NQ-phen Ln(<sc>iii</sc>) complexes inducing autophagy-mediated cell death.
Abstract Purpose To identify key cellular changes and molecular events in atrophic mucosa, we aimed to elucidate the mechanisms driving occurrence of chronic gastritis (CAG). Methods We used single-cell RNA sequencing (scRNA-seq) characterize epithelial state tissue microenvironment associated with CAG. The were identified by comparing differentially expressed genes (DEGs) between two mucosa states. Gene Ontology (GO) pathway enrichment analysis was explore potential functional each cell...
Biogenesis of lysosome-related organelles complex-1 (BLOC-1) is a component the molecular machinery required for biogenesis specialized and lysosomal targeting cargoes via endosomal to trafficking pathway. BLOS1, one subunit BLOC-1, implicated in membrane proteins. We found that degradation epidermal growth factor receptor (EGFR) were delayed BLOS1 knockdown cells, which rescued through overexpression. A key feature EGFR accumulation endolysosomes cells or knock-out mouse embryonic...
Breast cancer is one of the most lethal tumors in world, among which 15% are triple-negative breast cancers (TNBCs) with higher metastasis and lower survival rate. Anoikis resistance a key process during tumor metastasis, usually accompanied metabolism reprogram. In this study, we established an anchorage independent growth model for MDA-MB-231 cells investigated changes redox homeostasis. Results showed that detached-growth, tend to generate ATP through fatty acid oxidation (FAO), instead...
Excessive consumption of Δ9-tetrahydrocannabinol (THC) severely endangers human health and has raised public safety concerns. However, its quantification by readily rapid tools with simplicity low cost is still challenging. Herein, we found that a G-rich THC aptamer (THC1.2) can tightly bind to thioflavin T (ThT) strong fluorescence, which would be specifically quenched in the presence THC. Based on that, label-free ratiometric fluorescent sensor for sensing metabolite (THC-COOH) based...
We have demonstrated that T lymphocytes from the spleens of adult guinea pigs sensitized to group A streptococcal antigens are cytotoxic for cultured fetal pig heart cells. Lymphocyte cytotoxicity, measured by 51Cr release target cells, was stimulated sensitization in vivo with whole cell walls, and purified protoplast membranes emulsified complete Freund's adjuvant (CFA). Sensitization C CFA or alone produced little no specific activity. Target cells skeletal muscle, liver, skin were...
Osteosarcoma, the most common primary mesenchymal malignant tumor, usually has bad prognosis in man, with cancer stem-like cells (CSCs) considered to play a critical role tumorigenesis and drug-resistance. It is known that phosphatidylinositol 3-kinase (PI3K) involved regulation of tumor cell fates, such as proliferation, cycling, survival apoptosis. Whether how PI3K inhibitors might cooperate human osteosarcoma CSCs still unknown. We therefore evaluated effects LY294002, inhibitor, on cycle...
Abstract Constitutive NF-E2-related factor 2 (Nrf2, NFE2L2) activation has been recently reported to play a pivotal role in enhancing cell survival and resistance anticancer drugs many tumors. Wogonin had strong reversal potency via reduction of Nrf2 mRNA Adriamycin (ADR)-induced resistant human chronic myelogenous leukemia (CML) K562/A02, but the mechanism was still unclear. In this study, we aimed delineate by which suppressed transcription CML cells further evaluate effects on established...