A5103239639- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Helicobacter pylori-related gastroenterology studies
- Cancer-related molecular mechanisms research
- Bacteriophages and microbial interactions
- Veterinary medicine and infectious diseases
- Antibiotics Pharmacokinetics and Efficacy
- Epilepsy research and treatment
- Antibiotic Use and Resistance
- Cancer-related gene regulation
- Mycobacterium research and diagnosis
- Inflammatory Bowel Disease
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Vibrio bacteria research studies
- Diet and metabolism studies
- Cell Adhesion Molecules Research
- Microbial Metabolism and Applications
- Sepsis Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Pharmacological Effects and Toxicity Studies
- Barrier Structure and Function Studies
- Adipose Tissue and Metabolism
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2025
Jiangnan University
2019-2024
Wuxi Fourth People's Hospital
2019-2024
The First Affiliated Hospital, Sun Yat-sen University
2023-2024
Sun Yat-sen University
2021-2024
University of Science and Technology of China
2019-2024
Wenzhou Medical University
2019-2024
Ruian People's Hospital
2019-2024
Zhejiang Chinese Medical University
2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2020-2024
Adaptation to selective pressures is crucial for clinically important pathogens establish epidemics, but the underlying evolutionary drivers remain poorly understood. The current epidemic of carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant threat public health. In this study we analyzed genome sequences 794 CRKP bloodstream isolates collected in 40 hospitals China between 2014 and 2019. We uncovered subclonal replacement predominant clone ST11, where previously prevalent...
Moyamoya disease is an uncommon cerebrovascular disorder characterized by steno-occlusive changes in the circle of Willis and abnormal vascular network development. Ring finger protein 213 (RNF213) has been identified as important susceptibility gene for Asian patients, but researchers have not completely elucidated whether RNF213 mutations affect pathogenesis moyamoya disease. Using donor superficial temporal artery samples, whole-genome sequencing was performed to identify mutation types...
The genome of tomato ( Solanum lycopersicum L.) is being sequenced by an international consortium 10 countries (Korea, China, the United Kingdom, India, Netherlands, France, Japan, Spain, Italy, and States) as part larger “International Solanaceae Genome Project (SOL): Systems Approach to Diversity Adaptation” initiative. sequencing project uses ordered bacterial artificial chromosome (BAC) approach generate a high‐quality euchromatic sequence for use reference euasterids. Sequence deposited...
Abstract The occurrence and progress of colon cancer are closely associated with obesity. Therefore, the lipid metabolism, especially fatty acid is a significant section energy homeostasis in cells, it affects many important cellular processes. Oroxylin A one main bioactive flavonoids Scutellariae radix, which has strong anticancer effect but low toxicity to normal tissue. In previous studies, we have proved that oroxylin reprogrammes metabolism cells by inhibiting glycolysis. Here, further...
Abstract Liver cancer is the second cause of death from worldwide, without effective treatment. Traditional chemotherapy for liver has big side effects patients, whereas targeted drugs, such as sorafenib, commonly have drug resistance. Oroxylin A (OA) main bioactive flavonoids Scutellariae radix, which strong anti-hepatoma effect but low toxicity to normal tissue. To date, no differentiation-inducing agents been reported exert a curative on solid tumors. Here our results demonstrated that OA...
In this first national bloodstream infection (BSI) surveillance program in China, we assessed the composition of pathogenic bacteria and trends for antimicrobial susceptibility over a 6-year period China.Blood bacterial isolates from patients at hospitals participating Blood Bacterial Resistant Investigation Collaborative System (BRICS) were collected January 2014 to December 2019. Only isolate species per patient was eligible full study period. Antibiotic-susceptibility testing conducted by...
Ulcerative colitis (UC) is a non-specific chronic intestinal inflammatory disease with unclear etiology. Previous studies have suggested that the imbalance of Treg/Thl7 cells may be involved in development UC. It was found 6-gingerol can alleviate damage and improve weight loss mice. However, whether regulate balance Th17/Treg inhibit response remains to clarified.In this study, dextran sulfate sodium (DSS)-induced mouse model established, effects on cytokines were observed usingserial...
Pretreated mesenchymal stem cells (MSCs)-derived exosomes have shown great potential in the treatment of various inflammatory diseases. Recent evidence suggests that macrophage stimulator interferon genes (STING) signal activation plays a critical role sepsis and septic liver injury. Here, we aimed to investigate effects lipopolysaccharide (LPS)-pretreated bone marrow (BMSCs)-derived (L-Exo) on STING signaling Exosomes were collected from BMSCs medium via ultracentrifugation. Liver injury,...
Staphylococcus aureus (S. aureus) is a major nosocomial pathogen that causes variety of infections and toxicoses. In recent years, the percentage rifampicin-resistant S. has increased rapidly in China. The aims this study were to analyze 1) level rifampicin resistance its correlation with mutations rpoB gene, 2) molecular characterization isolates.88 isolates collected for study. Of 88 isolates, 83 (94.3%) high-level resistant (MIC≥8 mg/L) while remaining 5 (5.7%) had low-level (MIC, 2 4...
The aim of this study was to investigate the effect plant extracts combined with probiotics on prevention and treatment Eimeria tender infection in chicken. A total 180 12-day-old coccidia-free chicks were randomly divided into 6 groups 30 chickens each group. experimental as follows: group (blank control group), Group B (positive group) (infected coccidia without adding anti-coccidia drugs), C (probiotic D (plant extract test E + F (dickezulil group). Except blank group, 5×104 oocysts...
Proline-rich tyrosine kinase 2 (Pyk2), a non-receptor kinase, is member of the focal adhesion family and highly expressed in oocytes. Using combination confocal microscopy RNAi, we localized studied function both Pyk2 tyrosine-phosphorylated (p-Pyk2) during mouse oocyte fertilization early embryo development. At onset fertilization, p-Pyk2 were detected predominantly sperm heads cytoplasm. Upon formation male female pronuclei, its activated form leave cytoplasm accumulate two pronuclei. We...
Background:Streptococcus suis is a zoonotic pathogen that can cause severe infections such as meningitis and septicemia in both swine humans. Rapid accurate identification of the causative agent very important for guiding clinical choices administering countermeasures. Case Report: Here, we report case fatal S. infection patient who worked butcher China. The 59-year-old man, had previously undergone splenectomy, injured his finger while processing pork developed sepsis. While blood cultures...
Background: The imbalance of Treg/Thl7 cells and inflammatory injury are believed to be involved in the development ulcerative colitis (UC). Meanwhile, 6-gingerol has been reported alleviate intestinal damage mice models, but underlying mechanism remains elusive. Methods: In this study, dextran sulfate sodium (DSS)-induced models were established examine effects on IL-17 IL-10 secretion, activation NF-κB signaling was evaluated using enzyme-linked immunosorbent assay (ELISA), Western...
Oral administration remains the main treatment for H. pylori infection, but acidic environment of stomach, biofilm and drug resistance severely impair antibacterial effect orally clinical drugs. Here, a multifunctional nanodrug, composed rhamnolipid-assisted black phosphorus nanocomposite ([email protected]), is engineered resistant (H. pylori-R) treatment. The nanosystem utilized to efficiently deliver isolinderalactone (ISL), kind sesquiterpenoids compound purified from traditional Chinese...
Klebsiella pneumoniae has become a primary threat to global health because of its virulence and resistance. In 2015, China reported multidrug-resistant (MDR) hypervirulent K. (hvKp) isolates. The emergence MDR-hvKp poses significant public health. We collected 76 MDR isolates from the same hospital, which there were total six performed multilocus sequence typing (MLST) capsular typing, whole genome sequencing, comparative analysis, phylogenetic analysis as well phenotypic experiments,...
Purpose: To establish and evaluate a simple disk stacking plus micro-elution (DSE) method that can be routinely performed to rapidly detect the synergistic effect between aztreonam (ATM) ceftazidime/avibactam (CZA) against metallo-β-lactamase (MBL)-producing carbapenem-resistant Enterobacterales (CRE). Methods: The DSE was established, total of 32 MBL-producing CRE isolates collected from multiple centers were tested for ATM-CZA synergy. results obtained after 8 h incubation compared with...
Abstract Background Staphylococcus epidermidis is a common pathogen in medical device-associated infections and have an ability to form adherent slime. We aimed study the effects of icaA icaD genes on slime formation associated with catheter-associated infections. Methods S. isolates from central venous catheter blood patients infections, nasal vestibules healthy volunteers, intensive care unit hospital staff, patients, were collected. Slime phenotype was determined by Congo red agar test....
Acquisition of vancomycin resistance in Staphylococcus aureus is often accompanied by a reduction virulence, but the mechanisms underlying this change remain unclear. The present study was undertaken to investigate process clinical heterogeneous vancomycin-intermediate S. (hVISA) strain, 10827; an hVISA reference Mu3; and VISA Mu50, along with their respective series vancomycin-induced resistant strains. In these strains, increasing MICs were associated increased expression...
// Chen Qiao 1, * , Na Lu Yuxin Zhou 1 Ting Ni Yuanyuan Dai Zhiyu Li 2 Qinglong Guo Libin Wei State Key Laboratory of Natural Medicines, Jiangsu Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, People’s Republic Department Medicinal Chemistry, These authors contributed equally to this work Correspondence to: Guo, e-mail: anticancer_drug@163.com Wei, M.D, wlbiws_1986@aliyun.com Keywords: p53, translocation, oroxylin A, oxidative stress Received: August...
Although excessive salt consumption appears to hasten intestinal aging and increases susceptibility cardiovascular disease, the molecular mechanism is unknown. In this study, mutual validation of high (HS) fecal microbiota transplantation (FMT) in C56BL/6 mice was used clarify by which causes aging. Firstly, we observed HS vascular endothelial damage can accelerate associated with decreased colon serum expression superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), increased...