A5043942826- Moyamoya disease diagnosis and treatment
- RNA modifications and cancer
- RNA Research and Splicing
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and genetic disorders
- Muscle Physiology and Disorders
- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Neurological Complications and Syndromes
- Cancer-related molecular mechanisms research
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Multiple Sclerosis Research Studies
- Blood Coagulation and Thrombosis Mechanisms
- Connective tissue disorders research
- RNA regulation and disease
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Anesthesia and Neurotoxicity Research
- Renin-Angiotensin System Studies
- Genetic Associations and Epidemiology
- Protease and Inhibitor Mechanisms
- Angiogenesis and VEGF in Cancer
- Barrier Structure and Function Studies
Sun Yat-sen University
2015-2025
The First Affiliated Hospital, Sun Yat-sen University
2015-2025
Zhengzhou People's Hospital
2007
Moyamoya disease is an uncommon cerebrovascular disorder characterized by steno-occlusive changes in the circle of Willis and abnormal vascular network development. Ring finger protein 213 (RNF213) has been identified as important susceptibility gene for Asian patients, but researchers have not completely elucidated whether RNF213 mutations affect pathogenesis moyamoya disease. Using donor superficial temporal artery samples, whole-genome sequencing was performed to identify mutation types...
Abstract Background Progressive multiple sclerosis (PMS) is an uncommon and severe subtype of MS that worsens gradually leads to irreversible disabilities in young adults. Currently, there are no applicable or reliable biomarkers distinguish PMS from relapsing–remitting (RRMS). Previous studies have demonstrated dysfunction N 6-methyladenosine (m6A) RNA modification relevant many neurological disorders. Thus, the aim this study was explore diagnostic for based on m6A regulatory genes...
Objective We aimed to evaluate the association between serum uric acid levels at onset and prognostic outcome in patients with acute ischaemic stroke. Methods retrospectively analysed outcomes of 1166 stroke who were hospitalized our centre during August 2008 November 2012. Correlations analysed. Results Men had higher better neurological functional compared women. There was a strong negative correlation unfavourable outcomes. Generalized estimated equation analysis showed that level (>237...
Background: The use of antiplatelet agents in ischemic moyamoya disease (MMD) is controversial. This study aimed to investigate the effectiveness and safety therapy compared with conservative treatment surgical revascularization MMD patients. Methods: Ischemic patients were retrospectively enrolled from eight clinical sites January 2013 December 2018. Follow-up was performed through visits and/or telephone interviews first discharge 2019. primary outcome episodes further attacks, secondary...
Although familial forms of cerebral cavernous malformation are mainly attributed to three CCM genes ( KRIT1, CCM2 and PDCD10), no mutation is identified in sporadic cases with a unique lesion, indicating additional for malformation. To screen the candidate genes, we conducted whole exome sequencing 31 patients 32 healthy controls, 5 affected individuals carrying 6 heterozygous deleterious mutations RNF213 but individuals. further confirm was associated malformation, generated rnf213a...
Background: Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system with a variable natural history relapse remission. Previous studies have found many differentially expressed genes (DEGs) in peripheral blood MS patients healthy controls, but value these for predicting risk remains elusive. Here we develop validate effective noninvasive gene signature relapse-free survival (RFS) patients. Methods: Gene expression matrices were downloaded from...
Phosphodiesterase 4D (PDE4D) is a member of the large superfamily phosphodiesterases. PDE4D polymorphisms have been found to associate with ischemic stroke. Proliferation and migration vascular smooth muscle cells (VSMCs) play critical role in pathogenesis atherosclerosis. In this study, infection VSMCs lentivrius particles carrying shRNA direct against significantly inhibited platelet-derived growth factor-induced VSMC proliferation migration, inhibitory effects were not associated global...
Ischemic stroke (IS) is a multifactorial disorder caused by both genetic and environmental factors. The combined effects of multiple susceptibility genes might result in higher risk for IS than single gene. Therefore, we investigated whether interactions among were associated with an increased evaluating gene polymorphisms identified previous meta-analyses, including methylenetetrahydrofolate reductase (MTHFR) C677T, beta fibrinogen (FGB, β-FG) A455G T148C, apolipoprotein E (APOE) ε2-4,...
Summary Aim A recent genome‐wide association study identified a strong of covert magnetic resonance imaging infarcts with the single nucleotide polymorphism ( SNP ) rs2208454. The aim this was to determine whether rs2208454 is associated an increased risk for ischemic stroke IS ). Methods Ischemic patients (n = 712) and control subjects 774) from southern Chinese Han population were included. snapshot technique used genotype analysis. Results Compared GT + GG or genotype, frequency TT...
Aim of the study: The etiology isolated vertigo has been a substantial diagnostic challenge for both neurologists and otolaryngologists. This study was designed to detect recurrent due cerebral hypoperfusion using perfusion-weighted magnetic resonance imaging (PWI). Methods: We recruited patients whose clinical condition suspected be caused by hypodynamics brain; these individuals formed case group. generated two additional groups: negative group composed symptoms were problems associated...