A5055652630- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Vascular Malformations Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Genetic Associations and Epidemiology
- Obesity, Physical Activity, Diet
- Systemic Lupus Erythematosus Research
- Neuroscience and Neuropharmacology Research
- Voice and Speech Disorders
- Nuclear Receptors and Signaling
- Cerebrovascular and genetic disorders
- Child Nutrition and Feeding Issues
- Cytokine Signaling Pathways and Interactions
- Moyamoya disease diagnosis and treatment
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- EEG and Brain-Computer Interfaces
- Protease and Inhibitor Mechanisms
- Renin-Angiotensin System Studies
- Dysphagia Assessment and Management
- Food Security and Health in Diverse Populations
- Blood Coagulation and Thrombosis Mechanisms
- Histone Deacetylase Inhibitors Research
- Rheumatoid Arthritis Research and Therapies
- Obesity and Health Practices
Guangxi Medical University
2014-2025
First Affiliated Hospital of GuangXi Medical University
2014-2025
Guangxi Center for Disease Prevention and Control
2019-2024
Massachusetts General Hospital
2021-2024
First Affiliated Hospital of Chengdu Medical College
2018-2024
Children's Hospital of Chongqing Medical University
2021-2023
China International Science and Technology Cooperation
2023
Chongqing Medical University
2021-2023
MaineGeneral Medical Center
2021-2023
University of California, San Francisco
2016-2022
Background Current treatment options for chronic pain and depression are largely medication-based, which may cause adverse side effects. Integrative Medical Group Visits (IMGV) combines mindfulness techniques, evidence based integrative medicine, medical group visits, is a promising adjunct to medications, especially diverse underserved patients who have limited access non-pharmacological therapies. Objective Determine the effectiveness of IMGV compared Primary Care Provider (PCP) visit in...
Dysarthria is universal in Parkinson's disease (PD) during progression; however, the quality of vocalization changes often ignored. Furthermore, role acoustic parameters phonation PD patients remains unclear. We recruited 35 and 26 healthy controls to perform single, double, multiple syllable tests. A logistic regression was performed differentiate between protective risk factors among parameters. The results indicated that mean f0, max min jitter, duration speech median intensity speaking...
Abstract N6‐methyladenosine (m6A), an emerging modification of messenger RNA, has been implicated in many biological processes. However, its role Parkinson's disease (PD) remains largely unknown. Here, we investigated the m6A and underlying mechanism PD. First, 86 individuals with PD healthy controls were recruited from a pilot multicenter cohort. Levels modulators peripheral blood mononuclear cells patients measured using RNA methylation quantification kit quantitative real‐time PCR. The...
Abstract Background The nucleotide-binding oligomeric domain (NOD)-like receptor protein 3 (NLRP3) inflammasome is believed to be a key mediator of neuroinflammation and subsequent secondary brain injury induced by ischemic stroke. However, the role underlying mechanism NLRP3 in neonates with hypoxic-ischemic encephalopathy (HIE) are still unclear. Methods expressions including NLRP3, cysteinyl aspartate specific proteinase-1 (caspase-1) interleukin-1β (IL-1β),...
Manganese overexposure can induce neurotoxicity, lead to manganism and result in clinical manifestations similar those of parkinsonism. However, the underlying molecular mechanism is still unclear. This study demonstrated that MnCl2 induces mitophagy leads neurotoxicity by promoting BNIP3-mediated reactive oxygen species (ROS) generation.Human neuroblastoma SH-SY5Y cells were used throughout our experiments. Cell viability was detected cell proliferation/toxicity test kits. Mitochondrial...
Abstract Background Lupus enteritis (LEn) is a rare complication of systemic lupus erythematosus (SLE). Timely diagnosis and treatment LEn are necessary to prevent the most serious consequences — intestinal perforation, gastrointestinal bleeding, death. We compared clinical features SLE patients with without LEn. Methods The data inpatients at Suining Central Hospital from July 2012 June 2020 were examined. These matched (1:2 ratio) concurrently hospitalized who did not have two groups using...
Although familial forms of cerebral cavernous malformation are mainly attributed to three CCM genes ( KRIT1, CCM2 and PDCD10), no mutation is identified in sporadic cases with a unique lesion, indicating additional for malformation. To screen the candidate genes, we conducted whole exome sequencing 31 patients 32 healthy controls, 5 affected individuals carrying 6 heterozygous deleterious mutations RNF213 but individuals. further confirm was associated malformation, generated rnf213a...
Background: Tauopathies are a group of neurodegenerative disorders, including Alzheimer’s disease (AD) and frontotemporal lobar degeneration with tau pathology. Hyperphosphorylation modification promotes protein misfolding aggregation into neurofibrillary tangles, leading to impairments synaptic plasticity learning memory. However, very limited therapeutic strategies available. Objective: In the present study, we wanted investigate potential effects Dihydroartemisinin (DHA) on tauopathies....
Alzheimer's disease (AD) is a leading cause of dementia in the elderly. Mitogen-activated protein kinase phosphatase 1 (MKP-1) plays neuroprotective role AD. However, molecular mechanisms underlying effects MKP-1 on AD have not been extensively studied. MicroRNAs (miRNAs) regulate gene expression at post-transcriptional level, thereby repressing mRNA translation. Here, we reported that microRNA-429-3p (miR-429-3p) was significantly increased brain APP23/PS45 model mice and N2AAPP cells. We...
The objective was to evaluate if 2 pediatric weight management interventions delivered Hispanic, low-income children (one in a health center the other Young Men's Christian Association) were effective reducing BMI. We hypothesized that they would be equally effective.
Introduction: Alzheimer’s disease (AD) is a debilitating, progressive, neurodegenerative disorder characterized by the deposition of amyloid-β (Aβ) peptides and subsequent oxidative stress, resulting in cascade cytotoxic effects. Fangchinoline (Fan), bisbenzylisoquinoline alkaloid isolated from traditional Chinese herb Stephania tetrandra S. Moorec, has been reported to possess multiple potent biological activities, including anti-inflammatory antioxidant properties. However, potential...
BACKGROUND:Genetic polymorphisms have a potential clinical role in determining both inter-individual and inter-ethnic differences drug efficacy, but we not found any pharmacogenomics information regarding minorities, such as the Miao ethnic group. Our study aimed to screen numbers of group for genotype frequencies VIP variants determine between other human populations worldwide. MATERIAL AND METHODS:In this study, genotyped 66 Very Important Pharmacogene (VIP) selected from PharmGKB 98...
Parkinson's disease (PD) is a serious neurodegenerative affecting more than one million people globally. A mask-like face an important early motor symptom of PD; it develops gradually and asymptomatic. However, the relationship between severity PD changes in facial expressions remains unclear. We aimed to elucidate inner linkage. From January September 2019, we recruited 16 patients First Affiliated Hospital Chengdu Medical College healthy individuals. Participants performed phonation tests,...