A5016631882- High Altitude and Hypoxia
- Pharmacological Effects of Natural Compounds
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Hydrogen's biological and therapeutic effects
- Natural Antidiabetic Agents Studies
- Cardiac electrophysiology and arrhythmias
- Nigella sativa pharmacological applications
- Phytochemicals and Antioxidant Activities
- Chromatography in Natural Products
- Plant biochemistry and biosynthesis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sirtuins and Resveratrol in Medicine
- Medicinal Plants and Bioactive Compounds
- Cancer Cells and Metastasis
- Eicosanoids and Hypertension Pharmacology
- Phytochemistry and biological activity of medicinal plants
- Pharmacogenetics and Drug Metabolism
- Cancer Mechanisms and Therapy
- Medicinal Plant Pharmacodynamics Research
- Berberine and alkaloids research
- Ginseng Biological Effects and Applications
- Pulmonary Hypertension Research and Treatments
- Plant-based Medicinal Research
Xinjiang Medical University
2013-2025
Xinjiang Institute of Engineering
2024-2025
As two major types of primary liver cancers, the tumor immune microenvironment (TIME) hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) have been well studied separately. However, a systemic assessment similarities differences between TIME HCC ICC is still lacking. In this study, we pictured landscape combined by sequencing integrating 41 single-cell RNA-seq samples from four different tissue both malignancies. We found that T cells in tumors generally exhibit higher...
Diabetic kidney disease (DKD) is one of the complications diabetes mellitus, which triggers fibrosis and eventually develops into end-stage renal disease. Nuciferine (NF) most important functional components in lotus leaves (LL), but its role mechanism for treatment DKD are unclear. A high-fat-diet (HFD)-induced model KK-AY mice was established this study. NF significantly improved blood glucose biochemical indices mice. Furthermore, reduced levels mALB, UCRE, Scr, BUN urine. Further, extent...
Abstract Background Oxidative stress and endothelial cell dysfunction induced by high-altitude hypoxia have important roles in the pathological process of pulmonary hypertension (HAPH). Tannins present Terminalia bellirica (Gaertn.) Roxb. (TTR) pharmacological activities that produce oxidation resistance exert anti-inflammatory effects. Whether TTR exerts a protective effect on HAPH remains unknown. Methods A rat model was established. The mean arterial pressure (mPAP) animals measured,...
Pharmacognosy Magazine,2014,10,40,477-482.DOI:10.4103/0973-1296.141817Published:September 2014Type:Original ArticleAuthors:Dilinuer Maimaitiyiming, Guangmei Hu, Ainiwaer Aikemu, Shi Wen Hui, and Xiangyang Zhang Author(s) affiliations:Dilinuer Maimaitiyiming1, Hu2, Aikemu3, Hui4, Zhang2 1 Department of Cardiology, The first Teaching Hospital Xinjiang Medical University, XinjiangDepartment Xinjiang, China 2 3 Drug Analysis, 4 Animal Experiment, Urumqi General Lanzhou Military, 830011 Urumqi,...
Understanding the optimal extraction methods for flavonoids from Abelmoschus manihot flowers (AMF) is crucial unlocking their potential benefits. This study aimed to optimize efficiency of flavonoid AMF. After comparing methods, ultrasonic cell crusher demonstrated superior performance over conventional techniques. Four key factors—solid-to-liquid ratio (1:10 1:50 g·mL−1), ethanol concentration (55% 95%), time (10 50 min), and power (5% 25% 900 W)—were investigated normalized using entropy...
Abnormal Savda Munziq (ASMq), an Uighur medicine formula commonly used in the treatment of cancer, has been speculated to possess antioxidative and antiproliferative effects, regulate immune activity. The present study was designed systematically elucidate toxicity-reducing activity ASMq mice undergoing combination chemotherapy with doxorubicin 5-fluorouracil (5-FU). were divided into normal (saline, 10 ml/kg) + 5-FU groups (doxorubicin, 2.5 mg/kg; 5-FU, mg/kg on alternate days). In...
Abnormal Savda Munziq (ASMq), a traditional uyghur medicine, has shown anti-tumour properties in vitro. This study attempts to confirm these effects vivo and measure on the immune system.Kunming mice transplanted with Sarcoma 180 cells were treated ASMq (2-8 g/kg/day) by intra-gastric administration compared model cyclophosphamide (20 mg/kg/day). After 14th day post tumour implant, thymus, liver, spleen tumours removed, weighed, processed for histopathological analysis. Blood samples also...
This study investigated the immunomodulatory and anti-tumor effects of Nigella glandulifera Freyn Sint seeds (NGS) on Ehrlich ascites carcinoma in a mouse model.Kunming mice with transplanted tumor cells (EAC) were treated NGS by oral administration. On 11(th) day after EAC implant, thymus, liver, spleen kidney tumors removed for histopathological analysis. Blood samples taken hematological biochemical analyses.The results indicate that treatment leads to an increase TNF-α, IL-1β, IL-2 blood...
Drug response variability observed amongst patients is caused by the interaction of both genetic and non-genetic factors, frequencies functional variants are known to vary populations. Pharmacogenomic research has potential help with individualized treatments. We have not found any pharmacogenomics information regarding Uygur ethnic group in northwest China. In present study, we genotyped 85 very important pharmacogenetic (VIP) (selected from PharmGKB database) population compared our data...
Pharmacognosy Magazine,2012,8,30,141-148.DOI:10.4103/0973-1296.96568Published:May 2012Type:Original ArticleAuthors:Ainiwaer Aikemu, Abdiryim Yusup, Anwar Umar, Bénédicte Berk, Nicholas Moore, and Halmurat Upur Author(s) affiliations:Ainiwaer Aikemu1, Yusup2, Umar3, Berké3, Moore3, Upur4 1Department of Drug Analysis Traditional Uighur Medicine, Xinjiang Medical University, 830011 Urumqi, People's Republic China 2Department 3Department Pharmacology, China; Department University Victor Segalen...
BACKGROUND:Genetic polymorphisms have a potential clinical role in determining both inter-individual and inter-ethnic differences drug efficacy, but we not found any pharmacogenomics information regarding minorities, such as the Miao ethnic group. Our study aimed to screen numbers of group for genotype frequencies VIP variants determine between other human populations worldwide. MATERIAL AND METHODS:In this study, genotyped 66 Very Important Pharmacogene (VIP) selected from PharmGKB 98...
High-altitude pulmonary hypertension (HAPH) is one of the diseases with higher occurrence among people living in plateau areas. The possible mechanism angiotensin II receptor 1 inhibitor irbesartan improving HAPH was explored from perspective intestinal bacterial flora this study.A rat model established under simulated high-altitude hypobaric hypoxia. levels oxidative stress and vasoactive substances were detected after intervention, genomics analysis performed.High-altitude hypoxia-induced...
We analyzed the effects of total flavonoids from Dracocephalum moldavica L. (D. L.) on improving chronic mountain sickness (CMS) in rats using NMR hydrogen spectrum (1H-NMR) metabonomics technology.We extracted D. L with 60% ethanol reflux. A CMS model was established 48 Sprague-Dawley (SD) rats, which were then randomly divided into six groups (n = 8): control group (normal saline, 0.4 mL/100 g/d, ig); nifedipine (nifedipine tablets, 2.7 mg/kg/d, and high-, middle-, low-dose (DML.H, DML.M,...
Abnormal Savda Munziq (ASMq) is a traditional prescription in Uyghur Medicine, and its treatment of complex diseases such as tumors asthma has been proven to be effective medical clinical practice. The efficacy-enhancing toxicity-reducing properties ASMq were studied on mice with transplanted cervical cancer (U27) tumors, which treated 5-fluorouracil (5-FU) this work. To investigate the synergistic effect 5-FU U27 cells, inhibitory effects cell proliferation determined through MTT assay. 48...
Background:We established a rat model of chronic mountain sickness using acetyl-L-cysteine. Then we studied the effects and mechanisms acetyl-L-cysteine (Da) in rats with nuclear magnetic resonance (H1-NMR) metabolomics methods. Material andMethods:Using NMR spectroscopy combined pattern recognition orthogonal partial least squares discriminant analysis, analyzed impact Da on blood metabolism by determining different metabolites changes metabolic network after intragastric administration...
Abnormal Savda Munziq (ASMq), a traditional uyghur medicine, has shown anti-tumour properties in vitro. it was showed that total flavonoids of ASMq could inhibit the proliferation and enhance antioxidant ability human cervix cancer HeLa cell. This study attempts to confirm these effects on transplanted cervical (U27) mouse model vivo. Forty eight Kunming mice were randomly divided six groups: normal control group (Control group), U27 tumor (Model cyclophosphamide administration (CTX...
To study the effects of overexpression sarcoplasmic reticulum ATPase 2a (SERCA2a) gene on activity and protein expression SERCA2a after rapid atrial pacing (RAP) in New Zealand white rabbits. rabbits were randomly divided into a sham-operated group (group A), adeno-associated virus 1 (AAV1)/EGFP + fibrillation (AF) model B), or AVV1/SERCA2a AF C). The was used as negative control. Each consisted 10 animals. Groups B C injected with 500 μL AAV1-EGFP reporter AAV1-SERCA2a target gene,...