A5108060777- Nigella sativa pharmacological applications
- Pharmacological Effects of Natural Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Cardiovascular Disease and Adiposity
- Drug-Induced Hepatotoxicity and Protection
- Pulmonary Hypertension Research and Treatments
- Bioactive Compounds and Antitumor Agents
- Circular RNAs in diseases
- Travel-related health issues
- Pomegranate: compositions and health benefits
- High Altitude and Hypoxia
- Plant-based Medicinal Research
- Bioactive Natural Diterpenoids Research
- Toxin Mechanisms and Immunotoxins
- Extracellular vesicles in disease
- Chromatography in Natural Products
Xinjiang Medical University
2013-2024
First Affiliated Hospital of Xinjiang Medical University
2013-2024
Sixth Affiliated Hospital of Xinjiang Medical University
2021
Abstract Background Oxidative stress and endothelial cell dysfunction induced by high-altitude hypoxia have important roles in the pathological process of pulmonary hypertension (HAPH). Tannins present Terminalia bellirica (Gaertn.) Roxb. (TTR) pharmacological activities that produce oxidation resistance exert anti-inflammatory effects. Whether TTR exerts a protective effect on HAPH remains unknown. Methods A rat model was established. The mean arterial pressure (mPAP) animals measured,...
This study investigated the immunomodulatory and anti-tumor effects of Nigella glandulifera Freyn Sint seeds (NGS) on Ehrlich ascites carcinoma in a mouse model.Kunming mice with transplanted tumor cells (EAC) were treated NGS by oral administration. On 11(th) day after EAC implant, thymus, liver, spleen kidney tumors removed for histopathological analysis. Blood samples taken hematological biochemical analyses.The results indicate that treatment leads to an increase TNF-α, IL-1β, IL-2 blood...
High-altitude disease (HAD) describes the failure to adapt lack of oxygen found at high altitudes and therapeutic antioxidant effects have been attributed pomegranate peel (PP) extract. Network pharmacology, molecular docking, experimental validation were used study mechanisms responsible for alleviation HAD by PP. The aim was establish a reference future research aid technological development, particularly in clinical settings. pharmacology analysis showed that PP affected many targets via...
Glycyrrhetinic acid (GA) is a pentacyclic triterpene component in Glycyrrhize glabra L, it has demonstrated an inhibitive effect on high-altitude pulmonary hypertension (HAPH), but the molecular action still not known. We aimed to explore mechanism of GA for treatment HAPH based network pharmacology and docking method. Cell experiment validation was also conducted. The targets were screened using Swiss Target Prediction Batman databases. HAPH-related obtained GeneCards OMIM common diseases...
Adipose-derived mesenchymal stem cells (ADMSCs) can inhibite cell apoptosis and promote angio-genesis. Exosomes mainly serve as signaling molecules mediating communication. Unlike elaborating research about bone marrow derived cells, the role of exosomes secreted by ADMSCs in ischemic diseases is unclear. Oxidative stress inflammatory response are established to cause ischemia/reperfusion (I/R) injury. We assume that may exert a protective I/R injury inhibiting oxidative inflammation. 20–22...