A5100602429- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- BRCA gene mutations in cancer
- Berberine and alkaloids research
- HIV/AIDS drug development and treatment
- Ferroptosis and cancer prognosis
- Glioma Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Epigenetics and DNA Methylation
- Protease and Inhibitor Mechanisms
- Molecular Biology Techniques and Applications
- Renal Diseases and Glomerulopathies
- Hepatitis C virus research
- Lung Cancer Treatments and Mutations
- DNA Repair Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Tuberculosis Research and Epidemiology
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Eicosanoids and Hypertension Pharmacology
- Inflammasome and immune disorders
Northwest University
2014-2024
Xizang Minzu University
2014-2024
Ministry of Education of the People's Republic of China
2016-2024
Tibet Autonomous Region People's Hospital
2018
Hainan General Hospital
2017
Bridge University
2016
Second Affiliated Hospital of Xi'an Jiaotong University
2016
Northwest University
2016
Xi'an Jiaotong University
2004-2015
Minzu University of China
2015
Programmed death-1 (PD-1) is crucial in cancer and well characterized as a negative T-cell regulator that functions by delivering inhibitory signals. We aimed to evaluate the relationship between PD-1 polymorphisms (rs10204525, rs2227982, rs7421861) breast risk. selected 560 patients 583 age-, sex-, ethnicity-matched healthy controls from Northwest China. The were genotyped using Sequenom MassARRAY. Associations estimated with odds ratios (ORs) 95% confidence intervals (95% CIs). For...
Lung cancer has the highest mortality rate among cancers; however, its nosogenesis is still unclear. Genome-wide association studies have shown that telomerase reverse transcriptase (TERT) gene, located in chromosome 5p15.33 region, one of genes associated with risk lung cancer. In this case–control study, we genotyped 11 tag single-nucleotide polymorphisms TERT gene to evaluate their Han Chinese population. Two were found be on using χ2-test: rs4246742 [odds ratio (OR)=0.77, 95% confidence...
Aim: Tegafur is primarily converted to 5-fluorouracil (5-FU) by CYP2A6 in the human liver exert its antitumor effect. Our objective was comprehensively investigate effects of genetic polymorphisms on tegafur bioactivation activity. Materials & methods: Using a set over 45 Chinese livers, association between variations and 5-FU formation rates from tegafur, as well mRNA protein levels, determined. Results: A total 20 polymorphic variants haplotypes were identified. From...
Metastasis-associated in colon cancer-1 (MACC1), a newly identified oncogene, is involved angiogenesis, invasiveness, and metastasis many cancers. Epidemiological studies have indicated the associations between MACC1 polymorphisms cancer risk. However, association genetic breast (BC) was not clear. This study aimed to evaluate relationship BC We genotyped 4 single-nucleotide (SNPs) (rs975263, rs1990172, rs3735615, rs4721888) determine haplotypes 560 patients 583 age-, sex-, ethnicity-matched...
Acute myeloid leukemia (AML) is the most common blood tumor with poor prognosis. At present, research found that pathogenesis of AML related to many factors, such as recurrent somatic mutations and gene expression epigenetic changes, however, molecular mechanism still unclear. Long non-coding RNA MEG3 a newly suppressor plays very important role in regulation variety formation progression. Studies was significantly decreased AML. However, date, it not clear cause its abnormal expression....
IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated association between polymorphisms IgAN. Therefore, we performed a case-control study assess risk IgAN.Sequenom MassARRAY used genotype two SNPs (rs1861494 rs2430561) 351 patients with IgAN 310 healthy controls. Associations were evaluated as odd ratios (OR) 95% confidence intervals (CI).No found rs1861494 or clinical parameters. For rs2430561, AA...
The aim of this study was to investigate the association telomere length with breast cancer risk. We simultaneously explored between telomerase reverse transcriptase gene polymorphisms and length.We used real-time quantitative polymerase chain reaction measure relative (RTL) in genomic DNA extracted from peripheral blood 183 cases 191 healthy controls. Genotyping performed using Sequenom MassARRAY platform.Our results show that patients had significantly shorter RTLs than control subjects...
Purpose: Chronic obstructive pulmonary disease (COPD) is predicted to become the third most common cause of death and fifth disability in world by 2020. Recently, variants hypoxia-inducible factor 1α ( HIF1A ), cholinergic receptor, neuronal nicotinic, alpha polypeptide-5, iron-responsive element-binding protein 2 gene IREB2 ) genes were found be associated with COPD. This study aims identify whether variations these are related COPD Hainan population People’s Republic China. Patients...
Abstract Background Interleukin (IL)‐1β stimulates the proliferation and differentiation of osteoclast precursors into mature osteoclasts. IL‐1B polymorphisms may influence gene protein expression IL‐1β. The present study aimed to investigate association variants (rs2853550, rs1143643, rs3136558, rs1143630, rs1143627, rs16944 rs1143623) their interaction with osteoporosis risk among northwestern Chinese Han population. Methods AN Agena MassARRAY system (Agena, San Diego, CA, USA) was...
Colorectal cancer (CRC) is a common malignant tumor that influenced by an interaction between genetic and environmental factors. Currently, the inherited factors of CRC are unclear. Our study selected 19 tag single nucleotide polymorphisms (tSNPs) to investigate whether they were associated with in Han population. In this Chinese case–control study, we genotyped 203 cases 296 controls using Sequenom MassARRAY technology analyzed their associations χ2 tests, SNPStats software, SHEsis...
IL-18 polymorphisms influence the transcriptional activity of gene and associated with various diseases. However, their relationships hepatitis B virus-related liver diseases had not reached a consensus. So we conducted this case-control study view to clarifying association. We included four groups: healthy controls, chronic virus (CHB) carriers, cirrhosis (LC) hepatocellular carcinoma (HCC) groups each group 250 persons. Odd ratios (ORs) 95% confidence intervals (95%CIs) or without...
Abstract Skewed X-chromosome inactivation (SXCI) was found in some apparently healthy females mainly from Western countries. It has been linked to development of ovarian, breast and pulmonary carcinomas. The present study aimed observe the SXCI frequencies Chinese patients with esophageal carcinoma. DNA extracted peripheral blood cells 401 without a detectable tumor 143 female Exon 1 androgen receptor ( AR ) gene amplified, products different CAG alleles were resolved on denaturing...
// Xin Xue 1, 2 , Yi Qiu 3 Dong Jiang 4 Tianbo Jin 5, 6 Mengdan Yan 5 Xikang Zhu and Yonglie Chu 1 Department of Pathogen Biology Immunology, Xi’an Jiaotong University Health Science Center, 710061, China The Fourth Internal Medicine, Chest Hospital, TB Thoracic Tumor 710100, Second Inner Mongolia Medical University, Hohhot 010010, Key Laboratory Resource Biotechnology in Western (Northwest University), Ministry Education, School Life Sciences, Northwest 710069, Xizang Minzu Xianyang...
Drug response variability observed amongst patients is caused by the interaction of both genetic and non-genetic factors, frequencies functional variants are known to vary populations. Pharmacogenomic research has potential help with individualized treatments. We have not found any pharmacogenomics information regarding Uygur ethnic group in northwest China. In present study, we genotyped 85 very important pharmacogenetic (VIP) (selected from PharmGKB database) population compared our data...
Individual response to medications varies significantly among different populations, and great progress in understanding the molecular basis of drug action has been made past 50 years. The field pharmacogenomics seeks elucidate inherited differences disposition effects. While we know that populations ethnic groups are genetically heterogeneous, have not found any information regarding minority groups, such as Tajik group northwest China.We genotyped 85 Very Important Pharmacogene (VIP)...
Uygur Autonomous Region People's Hospital at Urumchi City, China.Gene and protein expressions of Wnt1 SFRP1 were quantified by immunohistochemistry western blotting.Wnt1 expression was significantly higher (P < 0.05) in CSCC samples than normal skin cells the control subjects; contrast, lower tissues that subjects 0.05).Moreover, found to be correlated with histopathological differentiation CSCC, negatively (r s = -0.473,P 0.015).Therefore, we concluded play important roles development could...
Monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 stimulate inflammation response by activating recruiting monocytes/macrophages. MCP-1 polymorphisms were reported to be associated with various diseases. To explore the relationship between IgA nephropathy (IgAN), we conducted this case-control study enrolling 351 IgAN patients 310 health controls. Odds ratios (ORs) 95% confidence intervals (CIs) calculated evaluate potential associations of susceptibility clinical parameters...