A5069622104- Multiple Myeloma Research and Treatments
- Osteoarthritis Treatment and Mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Biochemical and Molecular Research
- Cell death mechanisms and regulation
- Neonatal Respiratory Health Research
- interferon and immune responses
- Sulfur Compounds in Biology
- Sepsis Diagnosis and Treatment
- Bone Metabolism and Diseases
- Phagocytosis and Immune Regulation
- Cardiac Arrest and Resuscitation
- Birth, Development, and Health
- Cancer Mechanisms and Therapy
- Anesthesia and Neurotoxicity Research
- Cancer-related molecular mechanisms research
- Cardiac Ischemia and Reperfusion
- Neuroscience of respiration and sleep
- Immune Cell Function and Interaction
- Neonatal and Maternal Infections
- Fatty Acid Research and Health
- Streptococcal Infections and Treatments
- Immune Response and Inflammation
- Retinopathy of Prematurity Studies
- Phytochemical compounds biological activities
Anhui University of Traditional Chinese Medicine
2019-2024
Shandong Provincial Hospital
2024
Southern Medical University
2024
Anhui University
2022-2024
Shandong University
2024
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2022-2024
Anhui Provincial Hospital
2024
UCLA Jonsson Comprehensive Cancer Center
2012-2023
Second Xiangya Hospital of Central South University
2019-2023
Background/Aims: Stroke is among the top causes of death worldwide. Neuroprotective agents are thus considered as potentially powerful treatment stroke. Methods: Using both HT22 cells and male Sprague-Dawley rats in vitro vivo models, we investigated effect NaHS, an exogenous donor H2S, on focal cerebral ischemia-reperfusion (I/R) induced brain injury. Results: Administration NaHS significantly decreased infarcted area compared to I/R group a dose-dependent manner. Mechanistic studies...
<b><i>Background:</i></b> Inflammatory response exerts an important role in ischemia/reperfusion (I/R) injury. TLR4 and myeloid differentiation factor 88 (MyD88) are key components inflammation involved the cerebral I/R Irisin is a skeletal muscle-derived myokine produced after exercise, which was found to suppress inflammation. In this study, we investigated whether irisin could protect brain from injury through TLR4/MyD88 pathway....
Peptidoglycan (PGN), as the major components of bacterial cell wall, is known to cause excessive proinflammatory cytokine production. Toll-like receptor 2 (TLR2) abundantly expressed on immune cells and has been shown be involved in PGN-induced signaling. Although more evidences have indicated that PGN recognized by TLR2, role TLR2 recognition controversial. Mannan-binding lectin (MBL), a plasma C-type lectin, plays key innate immunity. More show MBL could suppress amplification inflammatory...
Receptor-interacting protein 3 (RIP3), a member of the RIP Ser/Thr kinase family, has been characterized as pro-apoptotic involved in tumor necrosis factor receptor-1 signaling pathway. In this study, we have mapped minimal region RIP3 sufficient for apoptosis induction to fragment 31 amino acids length. This also functions an unconventional nuclear localization signal confer import full-length nucleus trigger apoptosis, suggesting that is able play apoptosis-inducing role nucleus. addition,...
Several novel prokaryotic and eukaryotic expression vectors were constructed for protein transduction subcellular localization. These employed an N-terminal stretch of 11 basic amino acid residues (47-57) from the human immunodeficiency virus type 1 (HIV-1) TAT domain (PTD) translocation cellular The also contained a six-histidine (His(6)) tag at N- or C-terminus convenient purification detection, multiple cloning site easy insertion foreign genes. Some heterologous genes including HSV-TK,...
Background: Retinopathy of prematurity (ROP) is a retinal disease that causes blindness in premature infants.This study aimed to reveal the changes amino acids and derivatives plasma ROP patients compared with infants without ROP.Methods: Metabolomics targeting their was conducted assess levels (n=58) (n=25), KEGG pathway analysis used identify involved pathways.Results: Among 31 assessed metabolites, 4 were significantly altered group.Creatinine downregulated patients, while citrulline,...
We investigated the mechanism by which gene silencing of mTOR inhibitor, DEPTOR, induces cytoreductive effects on multiple myeloma (MM) cells.DEPTOR knockdown resulted in anti-MM several MM cell lines.Using an inducible shRNA to silence 8226 cells underwent TORC1 activation, downregulation AKT/SGK activity, apoptosis, cycle arrest and senescence.These latter cytotoxic were prevented paralysis (Raptor knockdown) but not overexpression AKT activity.In addition, DEPTOR knockdown-induced death...
Abstract Background Interleukin (IL)‐1β stimulates the proliferation and differentiation of osteoclast precursors into mature osteoclasts. IL‐1B polymorphisms may influence gene protein expression IL‐1β. The present study aimed to investigate association variants (rs2853550, rs1143643, rs3136558, rs1143630, rs1143627, rs16944 rs1143623) their interaction with osteoporosis risk among northwestern Chinese Han population. Methods AN Agena MassARRAY system (Agena, San Diego, CA, USA) was...
Abstract Background With the rapid development of economy in recent two decades, neonatology has been progressing quickly China. However, there is little knowledge about exact developmental status neonatal departments The aim this study was to assess resources available for care sick newborns mainland Methods Questionnaires were sent membership Chinese Neonatologist Association (CNA) and used survey scale, facilities, staff, technologies, transport systems preterm infants’ outcomes (NDs)...
Zhao, Hui, Wei Chai, Gao, Lixian Xu, Hui Zhang, and Yonghui Yang. Hyperoxygenated solution: effects on acute hypobaric hypoxia-induced oxidative damage in rabbits. High Alt. Med. Biol. 10:283–291, 2009.—High altitude (HA) exposure disrupts the efficiency of antioxidant system can lead to various organs tissues. The present study investigated effect hyperoxygenated solution (HOS) intravenous infusion therapy induced by hypoxia. Experimental rabbits were exposed a simulated high (HA),...
Because multiple myeloma (MM) cells are at risk for endoplasmic reticulum (ER) stress, they require a carefully regulated mechanism to promote protein translation of selected transcripts when proliferation is stimulated. MAPK-interacting kinases (MNKs) may provide this by enhancing cap-dependent small number critical transcripts. We, thus, tested whether MNKs played role in MM responses the growth factor interleukin-6 (IL-6). IL-6 activated MNK1 phosphorylation and induced its substrate,...
We examined the effects of acupotomy on PI3K/Akt signaling pathway to elucidate mechanism action articular chondrocyte apoptosis among rabbits with knee osteoarthritis (KOA).New Zealand were randomly assigned a healthy control group, placebo and drug 10 in each group. Changes chondrocytes by hematoxylin eosin staining, was measured electron microscopy immunofluorescence. The mRNA protein expression levels PI3K Akt real-time quantitative PCR Western blot.In contrast, less chromatin...