A5100382576- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Pain Mechanisms and Treatments
- Nanoparticle-Based Drug Delivery
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- ATP Synthase and ATPases Research
- Virus-based gene therapy research
- Inflammasome and immune disorders
- interferon and immune responses
- Neuropeptides and Animal Physiology
- Cell death mechanisms and regulation
- High Altitude and Hypoxia
- Galectins and Cancer Biology
- Bioactive Natural Diterpenoids Research
- Adenosine and Purinergic Signaling
- Dengue and Mosquito Control Research
- Liver physiology and pathology
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- DNA Repair Mechanisms
Air Force Medical University
2014-2025
University of Georgia
2025
Tianjin Medical University
2025
Tianjin Medical University Eye Hospital
2025
Shanxi Medical University
2020
Second Hospital of Shanxi Medical University
2020
Xijing Hospital
2002-2015
Sun Yat-sen University
2012
The First Affiliated Hospital, Sun Yat-sen University
2012
Center for Biologics Evaluation and Research
2010
Lung cancer is the widespread carcinogenesis in men and third most familiar women. It one of mostly aggressive human cancers, which responsible for around 1.4 million deaths per annum has utmost mortality incidence with 1.8 new incidences 1.6 yearly. In this present study, we have evaluated anticancer potential zinc oxide nanopartices (ZnONPs) synthesized from a root extract Euphorbia fischeriana (EF), through apoptosis signaling markers A549 lung cells. The EF-ZnONPs were transmission...
Abstract Background We have previously reported that inhibition of astrocytic activation contributes to the analgesic effects intrathecal ketamine on spinal nerve ligation (SNL)-induced neuropathic pain. However, underlying mechanisms are still unclear. c-Jun N-terminal kinase (JNK), a member mitogen-activated protein (MAPK) family, has been be critical for and pain development after SNL. Ketamine can decrease lipopolysaccharide (LPS)-induced phosphorylated JNK (pJNK) expression could thus...
Sevoflurane (Sev) is one of the most widely used pediatric anesthetics. The major concern neonatal repeated application Sev its potential long-term impairment cognition and learning/memory, for which there still lacks effective treatment. At cellular level, exerts toxic effects in multiple aspects, making it difficult interference. Melatonin a pineal hormone regulated by feedbacks to biological rhythm at physiological condition. Recent studies have revealed significant neuroprotective...
Microglia-mediated neuroinflammation is a key contributor to Parkinson's disease (PD) pathogenesis. Leucine-rich repeat kinase 2 (LRRK2), the leading genetic both familial and sporadic PD, has been implicated in driving this connection. However, its precise role remains incompletely understood due technical challenges. To address this, we utilized bacterial artificial chromosome (BAC) transgenic mouse model overexpressing human LRRK2-R1441G, which replicates features of PD. These mice were...
Abstract, Whether early exposure to general anesthetics hurts human brain development is still under discussion. Animal studies have documented multiple neurotoxicities of repeated/prolonged sevoflurane (Sev, a commonly used pediatric anesthetic) at the neonatal stage. Its effects on neural remain elusive. Here, by investigating progenitor cells derived from two embryonic stem cell lines, cerebral organoids and neuronal chimeric mice, we found that, although Sev inhibits differentiation...
Host factors interacting with the dengue virus (DENV) 3' UTR are involved in replication, but their roles remain poorly understood. We used RNA affinity capture and mass spectrometry to identify p100 as a host cellular protein associated DENV UTR. By using immunoprecipitation confocal immunofluorescence analysis we demonstrated an interaction between DENV-infected cells. identified A4 region (the extensive stem-loop structure at end) binding site of by studying deletion mutants. knockdown...
Although ketamine is widely used as an analgesic agent and has anti-allodynic effect on neuropathic pain, the underlying mechanisms are not fully explained by modern 'neuronal-based' theories. As emerging studies have focused critical role of spinal astrocytes in pathological pain states, we hypothesized that there exist some 'astrocytes-related' function ketamine. In present study, using nerve ligation (SNL) model, investigated anti-nociceptive effects intraperitoneal or intrathecal...
It has been suggested that propofol can modulate microglial activity and hence may have potential roles against neuroinflammation following brain ischemic insult. However, whether how inhibit post-cardiac arrest injury via inhibition of microglia activation remains unclear. A rat model asphyxia cardiac (CA) was created followed by cardiopulmonary resuscitation. CA induced marked in the hippocampal CA1 region, revealed increased OX42 P2 class purinoceptor 7 (P2X7R) expression, as well p38...
Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic blocked by significant systemic toxicity and limited efficacy at maximal tolerated dose, which need urgently be solved. The level cytosolic Ca2+ was assessed Fura-2 HCC cells. After changing using agonists or inhibitors, cell apoptosis detected flow cytometry. We also effect ionomycin parvalbumin on anti-tumor activity a mice model. Lastly, we...
Multidrug resistance (MDR) is a major clinical obstacle in treatment of gastric cancer (GC) and it accounts for the majority cancer-related mortalities. Shugoshin1 (SGO1) an important player appropriate chromosome segregation involved tumorigenesis. In this study, we found endogenous SGO1 overexpression multidrug-resistant GC cell lines SGC7901/VCR SGC7901/ADR compared with their parental line SGC7901. By enhancing expression SGO1, sensitivity SGC7901 cells to vincristine (VCR), adriamycin,...
Activated hepatic stellate cells are the main source of excessive collagen deposition in liver fibrosis. Here we report inhibitory effects combinational treatment two natural products, astragalus polysaccharide (APS) and β-elemene (ELE) on activation human cell line LX-2 cells. Cultured were treated with different concentrations APS or ELE for 24 48 hours. Cell viability/apoptosis was measured by MTT assay Annexin V/PI staining , related genes including α-SMA CD44 expressions real-time PCR...
Neuropathic pain is an intractable clinical problem. Drug treatments such as tramadol have been reported to effectively decrease neuropathic by inhibiting the activity of nociceptive neurons. It has also that modulating glial activation could prevent or reverse via administration a modulator inhibitor, propentofylline. Thus far, there no strategy incorporating both neuronal and participation for treating pain. Therefore, present research study was designed assess whether coadministration...
Abstract Sevoflurane is one of the most widely used anesthetics with recent concerns rising about its pediatric application. The synaptic toxicity and mechanisms underlying long‐term cognition impairment remain unclear. In this study, we investigated expression roles homeodomain interacting protein kinase 2 (HIPK2), a stress activating involved in neuronal survival plasticity, downstream c‐Jun N‐terminal (JNK)/c‐Jun signaling neonatal exposure. Our data showed that exposure results memory,...
Zhao, Hui, Wei Chai, Gao, Lixian Xu, Hui Zhang, and Yonghui Yang. Hyperoxygenated solution: effects on acute hypobaric hypoxia-induced oxidative damage in rabbits. High Alt. Med. Biol. 10:283–291, 2009.—High altitude (HA) exposure disrupts the efficiency of antioxidant system can lead to various organs tissues. The present study investigated effect hyperoxygenated solution (HOS) intravenous infusion therapy induced by hypoxia. Experimental rabbits were exposed a simulated high (HA),...
Abstract A pH‐sensitive drug targeting system for solid tumors was established based on N ‐isopropylacrylamide (NIPAAm) and chitosan conjugates. The mass ratio of NIPAAm adjusted to obtain super characteristic the structure studied by using Fourier transform infrared spectroscope confirm successful synthesis nanoparticles. release characteristics in vitro were as well. Human lung cancer cells A‐549 human fibroblast used test biocompatibility blank Podophyllotoxin (POD) loaded nanoparticles...
Clinical researches including the Mayo Anesthesia Safety in Kids (MASK) study have found that children undergoing multiple anesthesia may a higher risk of fine motor control difficulties. However, underlying mechanisms remain elusive. Here, we report erythropoietin receptor (EPOR), microglial associated with phagocytic activity, was significantly downregulated medial prefrontal cortex young mice after sevoflurane exposure. Importantly, inhibited (EPO)/EPOR signaling axis led to polarization,...