A5022608503- Genetic and Kidney Cyst Diseases
- Cancer-related molecular mechanisms research
- Cell death mechanisms and regulation
- RNA modifications and cancer
- Pituitary Gland Disorders and Treatments
- Microtubule and mitosis dynamics
- MicroRNA in disease regulation
- Congenital heart defects research
- Cellular transport and secretion
- Circular RNAs in diseases
- interferon and immune responses
- S100 Proteins and Annexins
- RNA Interference and Gene Delivery
- Adrenal Hormones and Disorders
- Phagocytosis and Immune Regulation
- Hedgehog Signaling Pathway Studies
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Telomeres, Telomerase, and Senescence
- Cancer-related Molecular Pathways
- Coronary Artery Anomalies
- Cardiovascular Disease and Adiposity
- Adrenal and Paraganglionic Tumors
- Ferroptosis and cancer prognosis
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Central South University
2022-2025
Chuzhou University
2021-2025
Anhui Medical University
2021-2025
Qingdao University
2024
Zunyi Medical University
2023
Jinan University
2010-2023
Changchun University of Science and Technology
2023
Ningbo No. 2 Hospital
2023
Peking Union Medical College Hospital
2019-2022
Primary cilia are microtubule-based membrane projections located at the surface of many cells. Defects in primary formation have been implicated a number genetic disorders, such as Bardet-Biedl Syndrome and Polycystic Kidney Disease. Recent studies demonstrated that polarized vesicular transport involving Rab8 its guanine nucleotide-exchange factor Rabin8 is essential for ciliogenesis. Here we report direct downstream effector Rab11, which functions trafficking from trans-Golgi network...
Lactate produced during ischemia-reperfusion injury is known to promote lactylation of proteins, which play controversial roles. By analyzing the lactylomes and proteomes mouse myocardium using mass spectrometry, we show that both Serpina3k protein expression its at lysine 351 are increased upon reperfusion. Both human homolog, SERPINA3, abundantly expressed in cardiac fibroblasts, but not cardiomyocytes. Biochemically, enhances stability. Using knockout mice overexpressing...
Promotion of cardiac angiogenesis in ischemic myocardium is a critical strategy for repairing and regenerating the after myocardial infarction (MI). Currently, effective methods to aid survival endothelial cells, avoid apoptosis achieve long-term are still being pursued. Here, we investigated whether telocyte (CT)-endothelial cell communication suppresses promotes cells facilitate during MI. Methods: CT exosomes were isolated from conditioned medium, their miRNA profile was characterized by...
Primary cilia are microtubule-based solitary membrane projections on the cell surface that play important roles in signaling and development. Recent studies have demonstrated polarized vesicular trafficking involving small GTPase Rab8 its guanine nucleotide exchange factor Rabin8 is essential for primary ciliogenesis. In this study, we show a highly conserved region of pivotal activation as Rab8. addition, activated conformation, interacts with Sec15, subunit exocyst downstream effector...
The constant self renewal and differentiation of adult intestinal stem cells maintains a functional mucosa for lifetime. However, the molecular mechanisms that regulate cell division epithelial homeostasis are largely undefined. We report here small GTPases Cdc42 Rab8a critical regulators these processes in mice. Conditional ablation mouse epithelium resulted formation large intracellular vacuolar structures containing microvilli (microvillus inclusion bodies) enterocytes, phenotype...
Hypertension, diabetes mellitus, and coronary artery disease are common comorbidities dangerous factors for infection serious COVID-19.Polymorphisms in genes associated with may help observe susceptibility severity variation.However, specific genetic the extent to which they can explain variation of unclear.Therefore, we evaluated candidate COVID-19 hypertension, disease.In particular, performed searches against OMIM, NCBI, other databases, protein-protein interaction network construction,...
Myocardium regeneration in adult mammals is very limited, but has enormous therapeutic potentials. However, we are far from complete understanding the cellular and molecular mechanisms by which heart tissue can regenerate. The full functional ability of amphibians to regenerate makes them powerful animal models for elucidating how damaged mature organs naturally reconstituted an organism. Like other amphibians, such as newts axolotls, Xenopus displays high regenerative capacity retina. So...
Background: Prediction of radiotherapeutic response before radiotherapy could help determine individual treatment strategies for patients with acromegaly. Objective: To develop and validate a machine-learning-based multiparametric MRI radiomics model to non-invasively predict in Methods: This retrospective study included 57 acromegaly who underwent postoperative between January 2008 2016. Manual lesion segmentation analysis were performed on each pituitary adenoma, 1561 features extracted...
Hepatocellular carcinoma (HCC) is one of the deadliest malignant tumors that are harmful to human health. Increasing evidence has underscored critical role competitive endogenous RNA (ceRNA) regulatory networks among various cancers. However, complexity and behavior characteristics ceRNA network in HCC were still unclear. In this study, we aimed clarify a phosphatase tensin homolog (PTEN)-related identify potential prognostic markers associated with HCC. The expression profiles three RNAs...
Objectives To develop and validate a nomogram to detect improved knee pain in osteoarthritis (OA) by integrating magnetic resonance imaging (MRI) radiomics signature of subchondral bone clinical characteristics. Methods Participants were selected from the Vitamin D Effects on Osteoarthritis (VIDEO) study. The primary outcome was 20% improvement score over 2 years participants administrated either vitamin or placebo. Radiomics features characteristics 216 extracted analyzed. randomly split...
Acute myeloid leukemia (AML) is a highly heterogeneous hematologic malignancy, with various clinical features influencing its prognosis. The aim of this study to evaluate the impact platelet count at diagnosis and recovery after induction chemotherapy on survival outcomes elderly AML patients. A total 109 patients who were treated in our center between 2017 2023 evaluated. According median counts time new diagnosis, cases divided into low group (≤40×109/L, n=54) high (>40×109/L, n=55)....
Cell polarization is essential for neuronal development in both embryonic and postnatal brain. Here, using primary cultures, vivo electroporation conditional genetic ablation, we show that the Ras-like small GTPase RalA its effector, exocyst, regulate morphology polarized migration of neural progenitors derived from subventricular zone, a major neurogenic niche Active promotes direct binding between exocyst subunit Exo84 PDZ domain Par6 through non-canonical PDZ-binding motif. Blocking...
Significance Rab8 is a key regulator of exocytosis. To understand how itself regulated in cells, it pivotal to study its guanine nucleotide exchange factor (GEF) Rabin8 activated. Here we demonstrate that has an autoinhibitory conformation. Phosphorylation by ERK1/2 response EGF relieves the autoinhibition Rabin8, thus promoting GEF activity on Rab8. In blocking phosphorylation inhibits vesicular trafficking plasma membrane. Our work identifies molecular mechanism for activation and reveals...
Abstract Context Postoperative hypercortisolemia mandates further therapy in patients with Cushing’s disease (CD). Delayed remission (DR) is defined as not achieving postoperative immediate (IR), but having spontaneous during long-term follow-up. Objective We aimed to develop and validate machine learning (ML) models for predicting DR non-IR CD. Methods enrolled 201 CD patients, randomly divided them into training test datasets. then used the recursive feature elimination (RFE) algorithm...
Cardiovascular disease is the leading cause of death in world due to losing regenerative capacity adult heart. Frogs possess remarkable capacities regenerate multiple organs, including spinal cord, tail, and limb, but response heart injury underlying molecular mechanism remains largely unclear. Here we demonstrated that cardiomyocyte proliferation greatly contributes regeneration X. tropicalis upon apex resection. Using RNA-seq qPCR, found expression Fos-like antigen 1 (Fosl1) was...
Antibiotics are extremely useful, but they can cause adverse impacts on host bodies. We found that antibiotic treatment altered the composition of gut microbiota and gene expression profile in corneal tissues postnatal mice decreased size thickness, angiogenesis limbal blood vessels, neurogenesis nerve fibers. The reconstitution with fecal transplants antibiotic-treated largely reversed these impairments development. Furthermore, C–C chemokine receptor type 2 negative (CCR2−) macrophages...