A5083115485- Cardiac Fibrosis and Remodeling
- Congenital heart defects research
- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Signaling Pathways in Disease
- Pancreatic function and diabetes
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Tissue Engineering and Regenerative Medicine
- Coronary Artery Anomalies
- Mesenchymal stem cell research
- Cancer-related gene regulation
- Reproductive Physiology in Livestock
- Neuroendocrine regulation and behavior
- Neurological Disorders and Treatments
- Polysaccharides Composition and Applications
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Molecular Biology Techniques and Applications
- Polyoxometalates: Synthesis and Applications
- Genetic and phenotypic traits in livestock
- Gas Sensing Nanomaterials and Sensors
- Redox biology and oxidative stress
- Physiological and biochemical adaptations
- Neuroscience of respiration and sleep
Guangzhou Medical University
2019-2023
Guangzhou Women and Children Medical Center
2023
Wuxi People's Hospital
2015-2020
Jinan University
2017-2018
Nanjing Medical University
2015
Shanghai Ocean University
2009
Hefei University of Technology
2004
Ischemic heart disease is a major global public health challenge, and its functional outcomes remain poor. Lysine crotonylation (Kcr) was recently identified as post-translational histone modification that robustly indicates active promoters. However, the role of Kcr in myocardial injury unknown. In this study, we aimed to clarify pathophysiological significance cardiac explore underlying mechanism. We investigated dynamic change both sites protein level left ventricular tissues at 2 time...
Myocardium regeneration in adult mammals is very limited, but has enormous therapeutic potentials. However, we are far from complete understanding the cellular and molecular mechanisms by which heart tissue can regenerate. The full functional ability of amphibians to regenerate makes them powerful animal models for elucidating how damaged mature organs naturally reconstituted an organism. Like other amphibians, such as newts axolotls, Xenopus displays high regenerative capacity retina. So...
Background: Pharmacological sedation during neonatal magnetic resonance imaging (MRI) is crucial for procedure success and minimizing artifacts. Hence, it vital to evaluate the effectiveness safety of conventional sedatives in this population. In study, we aim oral chloral hydrate combined with intranasal dexmedetomidine MRI. Methods: Neonates aged 0 28 days undergoing MRI were enrolled received followed by hydrate. Subsequently, scores, onset time, overall time sedation, as well any...
Atrial fibrillation (AF) is the most common type of arrhythmia in cardiovascular diseases. fibrosis an important pathophysiological contributor to AF. This study aimed investigate role clustered miR-23b-3p and miR-27b-3p atrial fibrosis. Human fibroblasts (HAFs) were isolated from appendage tissue patients with sinus rhythm. A cell model was achieved Ang-II-induced HAFs. Cell proliferation migration detected. We found that markedly increased tissues AF Ang-II-treated Overexpression enhanced...
The role of Mesenchymal-endothelial transition (MEndoT) in cardiac hypertrophy is unclear. To determine the difference between MEndoT-derived and coronary endothelial cells essential for understanding revascularizing strategy repair. Using lineage tracing we demonstrated that exhibit highly heterogeneous which were characterized with expression markers such as vascular cadherin(VECAD) occludin but low Tek receptor tyrosine kinase(Tek), isolectin B4, nitric oxide synthase(eNOS), von...
Rational: Wnt4 plays a critical role in development and is reactivated during fibrotic injury; however, the of cardiac repair remains unclear.In this study, our aim was to clarify pathophysiological mechanisms following acute ischemic reperfusion injury. Methods results:We investigated spatio-temporal expression injury found that upregulated as an early response gene fibroblasts near border zone associated with mesenchymal-endothelial transition (MEndoT), beneficial process for...
Two studies have recently focused on adult heart regeneration in Xenopus. While we reported cardiac myogenic Xenopus tropicalis after injury, Marshall and colleagues found no an injured laevis. Here, would like to join the discussion initiated by et al. who debated methods species differences both studies. We agree with their view that difference regenerative capacity could lead different results of these Moreover, suggest age animals used regeneration. A 5-year old X. laevis is much more...
Pancreatic beta cell damage induced by glucose toxicity is an important factor in type 2 diabetes mellitus (T2DM). It has become evident that endoplasmic reticulum stress (ERS)-induced apoptosis was contributed to dysfunction and insulin resistance. Our previous work showed emulsified isoflurane (EIso) could alleviate ERS lung reperfusion injury. This study aimed elucidate whether EIso rat islet RIN-m5F cells via inhibiting ERS.RIN-m5F were divided into five groups: the control group; 0.1G...
用热分解法制得不同混合比例的二元金属氧化物催化剂CoxCr1-xO3/2（x=0，0．2，0．4，0．6，0．8，1），使用SEM、XRD和XPS观察表征催化剂形貌、晶型和价态，使用线性扫描伏安、阶梯波伏安和恒电位测试电极活性、过电位和稳定性．结果表明，该Co3O4和绿铬矿型Cr203混合物形成固溶体CoxCr1-xO3/2.x=0．2时，Con2Cr080m电极性能较单-Co3O4和Cr2O3电极好，在高电位（1．0VVS．Ag／AgCl），其电流强度是C0304的15．2倍，Cr2O3的3．75倍，其过电位（η=0．0703v）也较Co3O4（77=0．6109V）和Cr2O3（η=0．435V）小，催化性能最好，在强碱性溶液（pH=13）中有良好的稳定性．
Objective To investigate the effects of emulsified isoflurane preconditioning on lung ischemia-reperfusion(I/R)injury in rats. Methods Thirty-two male Sprague-Dawley rats, weighing 250-320 g, were randomly divided into 4 groups(n=8 each)using a random number table: sham operation group(group S), group I/R, intralipid IL), and EI). Lung I/R was produced by clamping left hilum lungs for 1 h followed 2 reperfusion anesthetized rats.In S, intraperitoneal normal saline 10.5 ml/kg injected,...
Abstract Background Cardiac fibroblasts are considered to be highly heterogeneous mesenchymal cells after a cardiac injury. Understanding the heterogeneity of is fundamental importance for fibroblast-targeted strategies treat patients with heart disease. Advances in single-cell RNA-sequencing (scRNA-Seq) technology have provided possibility elaborate more depth. However, currently, most studies on scRNA-Seq performed using non-myocyte isolated at certain point time, which include very...
Abstract Background Diabetes mellitus (DM) is a critical disease that considered detriment to the health of people all over world. Endoplasmic reticulum stress (ERS) response cause by endoplasmic misfolded and unfolded protein aggregation, which induces cell apoptosis. Our previous work showed EIso could alleviate ERS in lung reperfusion injury. This study aimed elucidate whether Emulsified isoflurane (EIso) apoptosis induced glucose rat islet beta RIN-m5F via inhibiting ERS. Methods cells...