A5091134939- Ultrasound Imaging and Elastography
- Muscle Physiology and Disorders
- Tendon Structure and Treatment
- Pregnancy and preeclampsia studies
- Sports injuries and prevention
- Neonatal and fetal brain pathology
- Cardiac Structural Anomalies and Repair
- Cardiac Ischemia and Reperfusion
- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Nitric Oxide and Endothelin Effects
- Ultrasound and Hyperthermia Applications
- Diet and metabolism studies
- Eicosanoids and Hypertension Pharmacology
- Asthma and respiratory diseases
- Metabolism and Genetic Disorders
- Hormonal Regulation and Hypertension
- Cancer, Stress, Anesthesia, and Immune Response
- Pregnancy and Medication Impact
- High Altitude and Hypoxia
- Hypothalamic control of reproductive hormones
- Anesthesia and Neurotoxicity Research
- Sperm and Testicular Function
- Gynecological conditions and treatments
Guangzhou Medical University
2020-2024
Southern Medical University
2019-2024
Shenzhen Maternity and Child Healthcare Hospital
2024
Harvard University Press
2024
University of California, Davis
2024
Guangzhou Women and Children Medical Center
2024
Peking University Shenzhen Hospital
2024
Shenzhen Children's Hospital
2014-2022
Zhujiang Hospital
1999-2020
Chinese People's Liberation Army
2014
Ischemic heart disease is a major global public health challenge, and its functional outcomes remain poor. Lysine crotonylation (Kcr) was recently identified as post-translational histone modification that robustly indicates active promoters. However, the role of Kcr in myocardial injury unknown. In this study, we aimed to clarify pathophysiological significance cardiac explore underlying mechanism. We investigated dynamic change both sites protein level left ventricular tissues at 2 time...
Background Ventricular diastolic dysfunction in patients with repaired tetralogy of Fallot ( TOF ) may affect atrial mechanics. This study aimed to explore right RA and left LA mechanics their relationship ventricular function. Methods Fifty‐four (36 males), aged 17.8 ± 8.3 years, who had undergone repair at 3.9 3.3 years 40 healthy subjects 16.9 6.3 (P = 0.57) were studied. Right peak positive, negative, total strain, strain rate systole SR s ), early diastole ed contraction ac...
Background and Objective: Idiopathic central precocious puberty (ICPP) is characterized by early pubertal changes, the acceleration of growth velocity, rapid bone maturation that often results in reduced adult height. Gonadotrophin-releasing hormone agonist (GnRHa) currently considered to be an effective therapeutic agent. At present, GnRH stimulation test adopted as a gold standard for diagnosis ICPP efficacy evaluation GnRHa therapy. However, it difficult operate practice due cumbersome...
Objective: To establish Z-score regression equation derived from age for testicular volume measured by ultrasonography in normal boys aged 0 to 18 years old. Method: The length (L), width (W), and height (H) of 3,328 testicles 1,664 Chinese were ultrasonography. Lambert's formula: L × W H 0.71 was used calculate volume. established analysis predicted values standard deviations. Result: There no significant difference between left right volumes. Testicular positively correlated with age,...
This study sought to explore right (RV) and left ventricular (LV) mechanics ventricular-ventricular interaction in adolescents young adults late after percutaneous balloon pulmonary valvoplasty (PBPV) for valvar stenosis (PS).Potential effects of PS despite PBPV on cardiac have not been well defined. Thirty-one patients aged 20.2 ± 7.6 years were studied at 18 6 PBPV. Ventricular myocardial deformation was determined using speckle tracking echocardiography, while RV LV volumes ejection...
Osteoarthritis (OA) is primarily characterized by articular cartilage degradation.Hypoxia-inducible factor-1a (HIF-1a), a subunit of the basic helix-loop-helix-containing PER-ARNT-SIM (PAS) domain transcription factors, plays vital role in survival chondrocytes to hostile hypoxic microenvironment and complicates progression OA.In this study, we examined whether HIF-1a levels serum synovial fluid (SF) patients with knee OA were increased increase was correlated radiographic severity disease.A...
Aim Fetal bowel dilatation (FBD) in the late trimester of pregnancy can be related with varies prognosis. Our aims were to obtain antenatal factors that might have relevance for distinct prognosis FBD. Methods Seven features 68 pregnancies presented FBD assessed. The best cut‐off value predict intestinal outcomes was selected using receiver‐operating characteristics curves, and effective variables included into a logistic regression model. Results valves pathologies 14.5 mm fetus dilated...
OBJECTIVE. The purpose of this study was to investigate the potential high-speed T2-corrected multiecho (HISTO) MR spectroscopy (MRS) for rapidly quantifying fat content thigh muscles in children with Duchenne muscular dystrophy (DMD). SUBJECTS AND METHODS. This prospectively enrolled 58 boys DMD (mean age, 7.5 years; range, 4-11 years) and 30 age-matched healthy 7.2 at one institution over a 1-year period. T1- T2-weighted, Dixon, HISTO sequences were performed on right adductor magnus...
To investigate the reliability of quantitative analysis dynamic stretching muscle stiffness using shear wave elas-tography (SWE), and to evaluate influence stretched levels region interest (ROI) sizes on repeatability SWE measurements.SWE videos gastrocnemius medius were collected during ankle movement from plantar flexion (PF) 40° dorsiflexion (DF) 30°. Shear imageswere angles at PF 25°, 0°, DF 15°, 30°, representing slack status, mildly level, moderately maximal level medius, respectively....
To study the value of shear wave elasticity and dispersion imaging to evaluate viscoelasticity renal parenchyma in children with glomerular diseases.Forty-three diseases were prospectively evaluated by (SWE) (SWD); 43 healthy volunteers served as control group. The velocities (SWV) slopes measured at upper, middle, lower poles both kidneys. analysis mean SWV slope patient groups was used further SWE SWD disease.The disease higher than that group (1.61 ± 0.09 m/s vs. 1.43 0.07 m/s, p <...
To evaluate the effect of VKORC1, CYP2C9, GGCX, PROC, EPHX1 and CYP4F2 gene polymorphisms on Warfarin maintenance dose variation in Chinese Han Population.Four hundred eighty-eight patients with prosthetic heart valves, atrial fibrillation or pulmonary thromboembolism achieved stable were enrolled. TaqMan probe direct sequencing used to genotype Y9VKORC1, polymorphisms. Demographic characteristics, therapeutic concomitant medications collected for all patients. The polymorphisms, demographic...
Objective: To characterize the gut microbial community structure of two-kidney-one-clip (2K1C) hypertensive rats, provide new evidences for prevention and treatment hypertension. Methods: Adult male SD rats were divided into 2K1C model group sham operation (n=8 each). Blood pressure was recorded by tail-cuff technique weekly 4 weeks. Then, total fecal DNA in extracted. The principal components intestinal flora operated analyzed using Hiseq3000 sequencing platform. Additionally, real time...
Short summary: Deficiency in the orphan G protein coupled receptor 146 (GPR146) decreases blood lipid levels and protects against atherosclerosis mice, independent of LDL activity.
By detecting the DNA methylation and gene expression of long-chain 3-hydroxyacyl CoA dehydrogenase(LCHAD)in trophoblast cells, analyze correlation in early-onset preeclampsia(EPE), hemolysis, elevated liver enzymes, low platelets(HELLP)syndrome antiphospholipid syndrome(APS), to investigate molecular basis fatty acid oxidation changes different preeclampsia pathological pregnancy.Primary human cytotrophoblast cells HTR8/Svneo were treated with serum from patients EPE(14 cases), HELLP(12...
To investigate the plasma amino acid spectrum in infants more than 1-year-old with neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) order to identify potential diagnostic markers of NICCD.Infants less 1 year age who had been referred our hospital for investigation suspected conjugated hyperbilirubinemia between June 2003 and 2009 were eligible enrollment. A total 182 enrolled divided into three groups: diagnosed NICCD (n = 24), according gene testing and/or western...