A5028527387- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Mechanical Circulatory Support Devices
- Intensive Care Unit Cognitive Disorders
- Coronary Interventions and Diagnostics
- Hemodynamic Monitoring and Therapy
- Airway Management and Intubation Techniques
- Cardiac Arrest and Resuscitation
- Blood Pressure and Hypertension Studies
- Aortic aneurysm repair treatments
- Renal function and acid-base balance
- Cerebrovascular and Carotid Artery Diseases
- Acute Myocardial Infarction Research
- Apelin-related biomedical research
- Antiplatelet Therapy and Cardiovascular Diseases
- FOXO transcription factor regulation
- Neonatal Respiratory Health Research
- Heart Failure Treatment and Management
- Nosocomial Infections in ICU
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Disease and Adiposity
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Thermal Regulation in Medicine
- Acute Kidney Injury Research
- Cardiac Fibrosis and Remodeling
Guangzhou Medical University
2020-2025
Guangzhou Women and Children Medical Center
2020-2024
Jinan University
2007-2021
The First Affiliated Hospital, Sun Yat-sen University
2009
Sun Yat-sen University
2009
South China Agricultural University
2009
Red Cross Hospital
2008
Ischemic heart disease is a major global public health challenge, and its functional outcomes remain poor. Lysine crotonylation (Kcr) was recently identified as post-translational histone modification that robustly indicates active promoters. However, the role of Kcr in myocardial injury unknown. In this study, we aimed to clarify pathophysiological significance cardiac explore underlying mechanism. We investigated dynamic change both sites protein level left ventricular tissues at 2 time...
Introduction. Previous studies have shown that the nasogastric (NG) route seems equivalent to nasojejunal (NJ) in patients with severe acute pancreatitis (SAP). However, these used a small sample size and old criteria for diagnosing SAP, which may include some moderate according newly established SAP (Atlanta 2012 classification). Based on changes classifying we performed an up-to-date meta-analysis. Method. We reviewed PubMed, EMbase, China National Knowledge Infrastructure, Wanfang...
The discrimination and calibration accuracy of prediction models tends to become poor over time. performance predictive should be reevaluated periodically. aim this study was reassess the six commonly used for predicting 28-day mortality in patients with sepsis based on Sepsis 3.0 criteria.Patient data were extracted from fourth edition Medical Information Mart Critical Care (MIMIC IV) database. systemic inflammatory response syndrome (SIRS), Sequential Organ Failure Assessment (SOFA),...
<title>Abstract</title> Background Rac1 activation is a common occurrence in various tumors and often associated with poor prognosis, underscoring the potential therapeutic value of targeting pathway. Therefore, selectively inhibiting heightened activity tumor cells may represent an innovative approach to cancer treatment. Methods Techniques included siRNA-mediated gene silencing, luciferase reporter assays for promoter activity, Western blotting, qRT-PCR, chromatin immunoprecipitation...
Numerous studies have investigated the mean arterial pressure in patients with sepsis, and many meaningful results been obtained. However, few measured systolic blood (SBP) multiple times established trajectory models for sepsis different SBP trajectories.Data from were extracted Medical Information Mart Intensive Care-III database inclusion a retrospective cohort study. Ten values within 10 h after hospitalization extracted, interval between each value was 1 h. The ten admission analyzed...
Background To investigate the efficacy of intracoronary tirofiban during primary percutaneous coronary intervention (PCI) for patients with acute syndrome (ACS). Methods and Results The 118 aged 70 years above (average age 75±2) were divided into study (n=58, bolus tirofiban) control (n=57, intravenous groups. culprit vessels targeted PCI in all patients. Compared group, group showed better Thrombolysis In Myocardial Infarction (TIMI) flow grades TIMI myocardial perfusion (TMPG) immediately...
Many single-center studies and meta-analyses demonstrate that therapeutic hypothermia (TH), in which the body temperature is maintained at 32-35°C, exerts significant neuroprotection attenuates secondary intracranial hypertension after traumatic brain injury (TBI). In 2015, two well-designed multi-center, randomized controlled trials were published did not show favorable outcomes with use of TH adult patients TBI compared to normothermia treatment (NT). Therefore, we performed an updated...
At present, large-scale studies on the clinical characteristics of sepsis-induced cardiomyopathy (SIC) are lacking.To investigate SIC.Based analysis MIMIC-III public database, we performed a retrospective study involving sepsis patients who were admitted to intensive care unit (ICU) and had no concomitant cardiac disease. We used propensity score matching multivariate logistic regression ensure robustness results. The primary outcome was hospital mortality, secondary outcomes included number...
Abstract Background Previous studies have indicated that the ratio of lactate/albumin (L/A) has predictive value for prognosis critically ill patients with heart failure. Some also a low serum bicarbonate concentration is inversely related to mortality risk cardiogenic shock. However, and L/A predicting acute myocardial infarction (AMI) still unclear. We therefore conducted retrospective study research this problem. Methods The subjects were AMI, data source was Medical Information Mart...
Abstract Carcinoembryonic antigen-related cell adhesion molecules (CEACAM), such as carcinoembryonic antigen (CEA) and the oncofetal glycoprotein family, are tumor markers. The CEACAMs consist of 12 different human 5 murine CEACAMs. CEACAM family proteins participates in multiple biological processes that include immune response, angiogenesis, cancer. play a significant role cancer initiation development. Increasing evidence suggests members may be new biomarkers targets CEACEAMs tend to...
Knowledge concerning nutritional status of patients with chronic kidney disease (CKD) is limited. Nutritional Risk Screening-2002 (NRS-2002) has been used to evaluate the aspects according recommendation European Society for Clinical Nutrition and Metabolism. Here we aim assess prevalence characteristics risk in CKD by using NRS-2002. NRS-2002 scores 292 CDK were recorded first 24 hours subsequent their admission hospital. All have never on dialysis. BMI, weight various biochemical...
The risk of ventilator-associated pneumonia (VAP) is reduced when postpyloric enteral nutrition (EN) administered compared to gastric EN in specific populations. In the present study, we tested hypothesis that superior reducing incidence VAP elderly patients (age ≥ 75 years) who are admitted intensive care unit (ICU) and require mechanical ventilation. We performed a single-center randomized clinical trial involving were ICU required randomly assigned either group or group. primary outcome...
Abstract Background The administration of mesenchymal stem cells (MSCs) remains the most promising approach for cardiac repair after myocardial infarct (MI). However, their poor survival and potential in ischemic environment limit therapeutic efficacy heart MI. purpose this study was to investigate influence FoxC1-induced vascular niche on activation octamer-binding protein 4 (Oct4) fate MSCs under hypoxic/ischemic conditions. Methods Vascular microenvironment/niche induced by efficient...
The use of dobutamine in patients with sepsis is questionable. Some studies reported milrinone was used as an alternative inotropic agent. We aim to evaluate whether better than sepsis.Based on the analysis MIMIC III public database, we performed a big data, real-world study. According or milrinone, were categorised group group. propensity score matched (PSM) adjust for confoundings. primary outcome hospital mortality.In this study, after screening 38 605 patients, 235 included. One hundred...
Abstract Background The use of dobutamine in patients with sepsis is questionable currently. As the benefit septic unclear, we aimed to evaluate whether was associated decreased hospital mortality patients. Methods Based on analysis MIMIC III public database, performed a big-data, real world study. According or not, were categorized as group non group.We used propensity score matched (PSM) adjust for confoundings. primary outcome mortality. Results In present study, after screening 38,605...
Background: Heart failure (HF) is the terminal stage of various heart diseases. Conventional treatments have poor efficacy, and diuretic resistance can present. Previous studies found that use glucocorticoids enhance effect patients with reduce symptoms. However, relationship between glucocorticoid mortality in intensive care units unclear. Objectives: The aim this study was to determine association all-cause critically ill failure. Methods: information on extracted from MIMIC-III (Medical...
Background: Ventricular septal defect is a common congenital heart disease. As the disease progresses, likelihood of lung infection and failure increases, leading to prolonged hospital stays an increased complications such as nosocomial infections. We aimed develop nomogram for predicting over 14 days in pediatric patients with ventricular evaluate predictive power nomogram. hope that can provide clinicians more information identify high-risk groups soon possible give early treatment reduce...