A5088510559- Nitric Oxide and Endothelin Effects
- Cardiac Structural Anomalies and Repair
- Redox biology and oxidative stress
- Cardiac Fibrosis and Remodeling
- Tissue Engineering and Regenerative Medicine
- Cardiac Ischemia and Reperfusion
Guangzhou Medical University
2022
Ischemic heart disease is a major global public health challenge, and its functional outcomes remain poor. Lysine crotonylation (Kcr) was recently identified as post-translational histone modification that robustly indicates active promoters. However, the role of Kcr in myocardial injury unknown. In this study, we aimed to clarify pathophysiological significance cardiac explore underlying mechanism. We investigated dynamic change both sites protein level left ventricular tissues at 2 time...
Rational: Wnt4 plays a critical role in development and is reactivated during fibrotic injury; however, the of cardiac repair remains unclear.In this study, our aim was to clarify pathophysiological mechanisms following acute ischemic reperfusion injury. Methods results:We investigated spatio-temporal expression injury found that upregulated as an early response gene fibroblasts near border zone associated with mesenchymal-endothelial transition (MEndoT), beneficial process for...