A5113072738- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Ferroptosis and cancer prognosis
- Organ Transplantation Techniques and Outcomes
- Cancer Mechanisms and Therapy
- Extracellular vesicles in disease
- Cancer Immunotherapy and Biomarkers
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Gallbladder and Bile Duct Disorders
- Cancer Genomics and Diagnostics
- Inflammasome and immune disorders
- FOXO transcription factor regulation
- Immune cells in cancer
- Biliary and Gastrointestinal Fistulas
- Genetic factors in colorectal cancer
- Immune Cell Function and Interaction
Zhujiang Hospital
2019-2025
Southern Medical University
2019-2025
New York University
2025
Shanghai Power Equipment Research Institute
2024
The First Affiliated Hospital, Sun Yat-sen University
2009-2020
Sun Yat-sen University
2009-2020
University of South Carolina
2016-2017
China International Science and Technology Cooperation
2017
Key Laboratory of Guangdong Province
2016-2017
Medical University of South Carolina
2016-2017
Abstract The inflammatory microenvironment has been shown to play important roles in various stages of tumor development including initiation, growth, and metastasis. inflammasome is a critical innate immune pathway for the production active IL-1β, potent cytokine. Although inflammasomes are essential host defense against pathogens contribute autoimmune diseases, their role progression remains controversial. Here, our results demonstrate that IL-1β promoted growth metastasis animal human...
The occurrence and development of hepatocellular carcinoma (HCC) depends largely on such non-tumor factors as inflammatory condition, immune state, viral infection liver fibrosis. Various inflammation-based prognostic scores have been associated with survival in patients HCC, the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR) nutritional index (PNI). aspartate aminotransferase/platelet count (APRI) is thought to be a biomarker fibrosis cirrhosis. This study aims evaluate...
Pancreatic fistula (PF) remains the most challenging complication after pancreaticoduodenectomy (PD). The purpose of this study was to identify risk factors PF and delineate its impact on patient outcomes.We retrospectively reviewed clinical data 532 patients who underwent PD divided them into group no group. Risk outcomes following were examined.PF found in 65 (12.2%) cases, whom 11 classified ISGPF grade A, 42 B, 12 C. Clinically serious postoperative complications versus mortality,...
MicroRNAs (miRNAs) have been integrated into tumorigenic programs by regulating genes at post-transcriptional level. Long non-coding RNAs (lncRNAs) are novel targets for miRNAs. Here, we reported that miR-203 down-regulation was closely linked to advanced clinical features and poor overall survival (OS) of patients with hepatocellular carcinoma. We also confirmed oncogene ADAM9 (a disintegrin metalloproteinase 9)/oncogenic long RNA HULC (highly up-regulated in liver cancer) were inversely...
<title>Abstract</title> Background Rac1 activation is a common occurrence in various tumors and often associated with poor prognosis, underscoring the potential therapeutic value of targeting pathway. Therefore, selectively inhibiting heightened activity tumor cells may represent an innovative approach to cancer treatment. Methods Techniques included siRNA-mediated gene silencing, luciferase reporter assays for promoter activity, Western blotting, qRT-PCR, chromatin immunoprecipitation...
Laparoscopic caudate lobectomy (LCL) is one of the most challenging types laparoscopic liver resections. The main difficulty lies in deep anatomical position lobe, which closely adjacent to first and second hepatic ports inferior vena cava, increasing risk major bleeding during surgery. In addition a thorough understanding anatomy lobe tumor, comprehensive imaging assessment, three-dimensional reconstruction, flexible choice surgical approach also key reducing improving safety. We perform...
Adults tend to view men (more so than women) as default people , with numerous real-world consequences for gender equity. In the United States, tendency center in concepts of develops across middle childhood, yet specific mechanisms that contribute it remain unknown. Here, we investigate one subtle but potentially powerful social mechanism: category labels parents use describe boys/men and girls/women conversations their children. Across two studies ( N = 822 parent–child dyads,...
Tumor suppression of Transforming Growth Factor (TGF-β) signaling pathway requires an adaptor protein, Embryonic Liver Fodrin (ELF). Disruption ELF expression resulted in miscolocalization Smad3 and Smad4, then disruption TGF-β signaling. However, the prognostic significance for hepatocellular carcinoma (HCC) hasn't been clarified. This study aimed to investigate whether measuring both TGF-β1 provides a more powerful predictor HCC prognosis than either marker alone.TGF-β1 protein were...
Peripheral blood monocyte count is an easily assessable parameter of systemic inflammatory response. The aim this study was to determine whether prognostic in hepatocellular carcinoma (HCC) following hepatic resection. We retrospectively reviewed 351 patients with HCC treated resection from 2006 2009. Preoperative absolute peripheral count, demographics, and clinical pathological data were analyzed. On univariate multivariate analysis, elevated counts (≥545/mm3), tumor size ≥5 cm,...
Gelsolin (GSN), a cytoskeletal protein, is frequently overexpressed in different cancers and promotes cell motility. The biological function of GSN hepatocellular carcinoma (HCC) its mechanism remain unclear. expression was assessed cohort 188 HCC patients. effects on the migration invasion tumour cells were examined. Then, role growth vivo determined by using cancer metastasis assay. possible which progression explored. As result, tissues. High significantly correlated with late Edmondson...
Background Minimal residual disease (MRD) is considered an essential factor leading to relapse within 2 years (early relapse) after radical surgery, which challenging be detected by conventional imaging. Circulating tumor DNA (ctDNA) provides a novel approach for detecting MRD and predicting clinical outcomes. Here, we tried construct fixed panel plasma-only ctDNA NGS enable tumor-uninformed detection in hepatocellular carcinoma (HCC). Methods performed the followings: (i) profiling genomic...
// Fei Ji 1,2,3,* , Shunjun Fu Zhiyong Guo 1,2,3* Hui Pang 4 Dubo Chen 5 Xiaoping Wang 1,2,3 Weiqiang Ju Dongping Xiaoshun He Yunpeng Hua 6 and Baogang Peng 1 Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China 2 Guangdong Provincial Key Laboratory of Donation Immunology, 3 International Cooperation Base Science Technology (Organ Transplantation), Department Medical Records, Medicine, Liver Surgery, * These authors have contributed equally...
The abnormal expression of long noncoding RNAs (lncRNAs) is associated with human carcinoma. present study aimed to investigate the mechanisms underlying function lncRNA AK002107 in progression hepatocellular carcinoma (HCC). differential lncRNAs between HCC and paired nontumor tissues was identified using microarrays, correlation clinical prognosis analyzed. We investigated role tumor biology vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT), colony formation,...
Mesenchymal stem cells (MSCs) have potential role in organ regeneration therapy. Previous work indicating that MSCs confer protection against liver disease. Here, we aimed to determine the application of human placenta-derived extracellular vesicles (hPMSCs-EVs) via experimental hepatectomy. hPMSCs-EVs were administered intravenously 24 h before 70% partial hepatectomy, specific composition was identified by sequencing and validated quantitative polymerase chain reaction, including...
NEK2 is a member of the NIMA-related family serine/threonine centrosomal kinases. We analyzed relationship between differential expression and hepatocellular carcinoma (HCC) patient outcomes after liver transplants. also studied microRNAs that affect expression. Analysis multiple microarrays in Oncomine database revealed was higher HCC tissues than adjacent normal tissues. High correlated with tumor size, pathological grade macro- microvascular invasion. Consequently, patients exhibiting...
Gamma-glutamyltranspeptidase (γ-GGT), an oxidative stress marker, is correlated with inflammation in the extracellular hepatic microenvironment. This study aimed to evaluate prognostic value of serum γ-GGT levels patients hepatocellular carcinoma (HCC) after hepatectomy. Three hundred and eight who underwent resection for HCC were included study. Preoperative levels, as well demographic, clinical, pathologic data, analyzed. The optimal cutoff was 88 U/L. All divided into ≤ U/L group (n =...