A5012349907- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Gallbladder and Bile Duct Disorders
- Vascular Malformations and Hemangiomas
- HER2/EGFR in Cancer Research
- Graphene and Nanomaterials Applications
- Cancer Mechanisms and Therapy
- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Cancer-related gene regulation
- Glycosylation and Glycoproteins Research
- Tumors and Oncological Cases
- Viral-associated cancers and disorders
- Cancer Cells and Metastasis
- Acupuncture Treatment Research Studies
- Liver Disease Diagnosis and Treatment
- Tuberous Sclerosis Complex Research
- Dendrimers and Hyperbranched Polymers
- Protein Kinase Regulation and GTPase Signaling
- Medicinal Plant Pharmacodynamics Research
- Advanced Polymer Synthesis and Characterization
- Lung Cancer Research Studies
- Inflammatory Biomarkers in Disease Prognosis
Sun Yat-sen University
2015-2024
The First Affiliated Hospital, Sun Yat-sen University
2006-2024
Zhujiang Hospital
2024
Southern Medical University
2024
General Hospital of Guangzhou Military Command
2024
The occurrence and development of hepatocellular carcinoma (HCC) depends largely on such non-tumor factors as inflammatory condition, immune state, viral infection liver fibrosis. Various inflammation-based prognostic scores have been associated with survival in patients HCC, the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR) nutritional index (PNI). aspartate aminotransferase/platelet count (APRI) is thought to be a biomarker fibrosis cirrhosis. This study aims evaluate...
Once bone metastasis occurs in lung cancer, the efficiency of treatment can be greatly reduced. Current mainstream treatments are focused on inhibiting cancer cell growth and preventing destruction. Microwave ablation (MWA) has been used to treat tumors. However, MWA may damage surrounding normal tissues. Therefore, it could beneficial develop a nanocarrier combined with microwave metastasis. Herein, microwave-responsive nanoplatform (MgFe
TRIM62 (tripartite motif containing 62) has been found to act as a tumor suppressor of several cancers. However, its precise biological role and related mechanism remain unknown in cervical cancer (CC).Quantitative Real-time PCR western blot were adopted detect the mRNA protein expression level both human CC cell lines tissues. Immunohistochemistry was used measure 30 normal 189 Univariate multivariate Cox regression analyses Kaplan-Meier survival performed investigate association between...
Despite significant improvements in targeted therapies for patients with advanced gastric cancer (GC), the prognosis of those remains poor. This study explores expression and clinicopathological significance human epidermal growth factor receptor 2, 3 4 (HER2, HER3, HER4) GC, order to find more prognostic biomarkers GC putative targets therapy.Immunohistochemistry was performed HER2, HER3 HER4 498 using tissue microarray. Correlations between features, as well were statistically analysed.The...
TSP50 (testes-specific protease 50) has been reported to be a candidate oncogene and is overexpressed in various cancers. Our previous study demonstrated that protein elevated gastric cancer, its high expression associated with unfavorable prognosis lymph node metastasis. However, the role of cancer remains elusive. qRT-PCR, western blot were used determine cell lines. Role proliferation invasion was examined by BrdU incorporation assay, count, wound healing transwell assay....
Novel multifunctional drug nanocarriers with pH and ROS dual-responsibilities were developed using enzymatically synthesized materials.
Mixed adenoneuroendocrine carcinoma (MANEC), also known as high- grade mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) in the World Health Organization (WHO) classification of tumors endocrine organs (2017), is a rare gastric malignancy. Here, we present 10 cases MANEC and analyse their clinicopathological features lymph node metastatic patterns.Six patients were male, four female. The mean age was 67.9 years. Grossly, most presented ulcerative mass, located fundus or/and cardia....
"Driver gene-negative" lung adenocarcinoma (LUAD) was of rare treatment options and a poor prognosis. Presently, for them, few biomarkers are available stratification analysis to make appropriate strategy. This study aimed develop DNA-methylome-based signature realize the precise risk-stratifying. Here, an Illumina MethylationEPIC Beadchip applied obtain differentially methylated CpG sites (DMCs). A four-CpG-based signature, named as TLA, successfully established, whose prognosis-predicting...
Background: Postoperative cholangitis is a common but severe complication after Kasai portoenterostomy for biliary atresia (BA).This study aimed to identify its prognostic factors.Methods: Two sets of liver paraffin-embedded tissue samples were collected from BA patients who received (n = 25 and n 31, respectively).Patients divided into non-cholangitis groups.The infiltration CD4 + , CD8 CD45RO CD68 cells expression Beclin1 quantitatively evaluated in immunohistochemical analysis.Results:...
Deleted in liver cancer 2 (DLC2) is a tumor suppressor, associated with various types of cancer. The aim the present study was to analyze expression DLC2 breast cancer, its clinical significance and effect on cell behavior. evaluated by immunohistochemistry 131 cases Associations among clinicopathological features were analyzed, effects proliferation, motility, migration invasion DLC2-knockdown lines observed. results indicated that expressed 42.75% (56/131) 79.39% adjacent normal tissues...
To observe the effect of grain-moxibustion at Zusanli (ST 36) and Weishu (BL 21) on neutrophil to lymphocyte ratio (NLR) quality life (QOL) in patients with advanced gastric cancer.Sixty cancer were randomly divided into an observation group a control group, 30 cases each one. In conventional chemotherapy regimen combined symptomatic treatment，such as antiemetic, acid-suppressive, liver-protecting drugs. On basis treatment was applied 9 cones for acupoint, once day total 90 days. The levels...
Reports showed that some of intrahepatic cholangiocarcinoma (ICC) patients with lymph node metastasis (LNM) may also gain survival benefit undergone resection. However, the effect extent LNM on prognosis and surgical indication is barely discussed.From September 1994 to November 2018, primary ICC initial curable surgery were enrolled. Based LNM, we divided these into 4 groups, including no (group N0), hepatoduodenal ligament or common hepatic artery (region A, group A), gastrohepatic nodes...
Gastrointestinal stromal tumors are the most common mesenchymal of digestive tract, which sporadic, and familial GISTs with germline mutations rarely seen. Here, we report a 26-year-old female p. W557R mutation in exon 11 KIT gene. The proband her father sister presented multifocal GIST pigmented nevi. All 3 patients underwent surgery imatinib therapy. To date, only 49 kindreds 6 PDGFRA have been reported. Summarizing reported kindreds, majority manifest as multiple primary complicated...
Objective To explore the diagnosis and treatment of Kaposiform hemangioendothelioma (KHE), deepen understanding KHE Kasabach-Merritt phenomenon (KMP), discuss optimal for KHE. Methods From January 2008 to August 2016, 13 cases were confirmed by surgery or biopsy pathology admitted First Affiliated Hospital Sun Yat-Sen University, clinical analyzed retrospectively. Results There patients(7 males 6 females) with a median age 1.0 years(0.2-10.0 years), 84.6%(11/13 cases) infants...