A5100736539- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Renal cell carcinoma treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ovarian function and disorders
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Pregnancy and preeclampsia studies
- Bladder and Urothelial Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Peptidase Inhibition and Analysis
- Medical Research and Treatments
- Kruppel-like factors research
- Building materials and conservation
- Conservation Techniques and Studies
- Lipid metabolism and disorders
- Cancer, Hypoxia, and Metabolism
- Traditional Chinese Medicine Studies
- Immune Cell Function and Interaction
Huazhong University of Science and Technology
2024-2025
Tongji Hospital
2024-2025
Union Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Xiyuan Hospital
2024
Zhejiang University of Technology
2024
Wuhan University
2019-2024
Renmin Hospital of Wuhan University
2019-2024
Union Hospital
2024
Tsinghua University
2023-2024
Immersion, interaction, and imagination are three features of virtual reality (VR). Existing VR systems possess fairly realistic visual auditory feedbacks, however, poor with haptic feedback, by means which human can perceive the physical world via abundant properties. Haptic display is an interface aiming to enable bilateral signal communications between computer, thus greatly enhance immersion interaction systems. This paper surveys paradigm shift occurred in past 30 years, classified into...
RNA sequencing (RNA-seq) is one of the most widely used technologies in transcriptomics as it can reveal relationship between genetic alteration and complex biological processes has great value diagnostics, prognostics, therapeutics tumors. Differential analysis RNA-seq data crucial to identify aberrant transcriptions, limma, EdgeR DESeq2 are efficient tools for differential analysis. However, requires certain skills with R language ability choose an appropriate method, which lacking...
RNA sequencing (RNA-seq) is one of the most widely used technologies in transcriptomics as it can reveal relationship between genetic alteration and complex biological processes has great value diagnostics, prognostics, therapeutics tumors. Differential analysis RNA-seq data crucial to identify aberrant transcriptions, limma, EdgeR DESeq2 are efficient tools for differential analysis. However, requires certain skills with R language ability choose an appropriate method, which lacking...
Background. Endometrial cancer greatly threatens the health of female. Emerging evidences have demonstrated that DNA methylation and immune infiltration are involved in occurrence development endometrial cancer. However, mechanism prognostic biomarkers still unclear. In this study, we assess via bioinformatic analysis. Methods. The latest RNA-Seq, data, clinical data related to were downloaded from UCSC Xena dataset. methylation-driven genes selected, then risk score was obtained using...
Acute kidney injury (AKI) represents a significant challenge to global public health problem and is associated with poor outcomes. There still considerable debate about the effect of mean blood glucose (MBG) coefficient variation (CV) on short-term mortality AKI patients. This retrospective cohort study aimed explore association between glycemic variability in patients AKI. Data from Medical Information Mart for Intensive Care IV (MIMIC-IV) database were analyzed, including 6,777 adult MBG...
Background: Previous studies have established a general understanding of the association between risky sexual behavior, genetic risk, and cervical carcinoma. However, these were conducted several years ago lack systematic analysis using high-quality population-based data. Methods: We prospective nested case-control study to identify behaviors developed behavior score. Combining score we evaluated effect reproductive PRS on carcinoma through conditional logistic regression models. Results:...
Abstract Insufficient trophoblast invasion is the key factor for occurrence of recurrent spontaneous abortions (RSA). Our previous studies identified Yin Yang 1 (YY1) as a transcription involved in regulation invasiveness at maternal–fetal interface. Long noncoding RNAs (lncRNAs) can regulate gene expression and autophagy many ways. The purpose this study was to explore relationship between YY1 lncRNAs mechanism by which affect biological behavior trophoblasts. Bioinformatic analysis...
Abstract Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disease in women, with clinical manifestations of anovulation hyperandrogenaemia. The treatment PCOS mainly focuses on improving symptoms, such as insulin sensitivity or menstrual disorder, through drug treatment. However, due to the pathogenesis diversity PCOS, there still lack effective clinics. Metabolic disorder key factor occurrence PCOS. Brown adipose tissue (BAT) special human body that can participate...
Remodeling the endogenous regenerative microenvironment in wounds is crucial for achieving scarless, functional tissue regeneration, especially recovery of skin appendages such as sweat glands burn patients. However, current approaches mostly rely on use exogenous materials or chemicals to stimulate cell proliferation and migration, while remodeling a pro-regenerative remains challenging. Herein, we developed flexible sono-piezo patch (fSPP) that aims create an promote repair wounds. This...
Background: Cervical carcinoma is one of the most common malignant gynecological tumors and associated with high rates morbidity mortality. Early diagnosis early treatment can reduce mortality rate cervical cancer. However, there still no specific biomarkers for detection cancer prognosis. Therefore, it greatly urgent in searching correlated prognosis Results: The mRNA microRNA expression profile datasets (GSE7803, GSE9750, GSE63514, GSE30656) were downloaded from Gene Expression Omnibus...
Background: Ovarian cancer (OC), a representative female reproductive system tumor, is one of the most malignant tumors in female. The important reason for its poor prognosis because high rate chemotherapy resistance. Results: This study aims to explore effects miR-21 on resistance OC cells. functions proliferation, migration and invasion cells were assessed by transwell, clonal formation CCK8 assay. Expression levels miR-21, P-gp CD44v6 SKOV3 (cisplatin sensitive) SKOV3/DDP resistant)...
Cytotoxic T-lymphocyte associated protein 4 (CTLA4) inhibitors have been shown to significantly prolong the overall survival (OS) in a wide range of cancers. However, its application clear cell renal carcinoma (ccRCC) is limited due therapy response, and prognostic value CTLA4 ccRCC has not investigated detail. By using immunohistochemistry, Kaplan-Meier (K-M) analysis, uni- multi-variate Cox we comprehensively systematically studied ccRCC. Then, applied Gene Ontology (GO), Kyoto...
Hepatocellular carcinoma (HCC) ranks fifth among common cancers and is the second most cause of cancer-related mortality worldwide. This study aimed at identifying an immune-related long noncoding RNA (lncRNA) signature as a potential biomarker with prognostic value to improve early diagnosis provide therapeutic targets for HCC patients. The subjects this were samples complete transcriptome data clinical information downloaded from Cancer Genome Atlas (TCGA) database. We then extracted mRNA...
Hepatocellular carcinoma (HCC) is one of the main causes cancer-associated deaths globally, accounts for 90% primary liver cancers. However, further studies are needed to confirm metabolism-related gene signature related prognosis patients with HCC.Using "limma" R package and univariate Cox analysis, combined LASSO regression a was established. The relationship between overall survival (OS) HCC analyzed. RT-qPCR used evaluate expression genes in clinical samples. GSEA ssGSEA algorithms were...
Abstract Background Ovarian cancer (OC) has the highest mortality rate in gynecologic tumors. Despite decades of continuous efforts, survival patients not improved significantly, mostly due to drug resistance. Exosomes are hot topics recent years. Cells can affect biological behaviors other cells by transferring exosomes. So far, numerous researchers have found that tumor secrete exosomes which play a important role development Solid tumors promote angiogenesis. When resistance occurs, it...
Abstract In this study, we attempted to evaluate the prognostic value of infiltrating immune/stromal cells in clear cell renal carcinoma (ccRCC), by using immune scores and stromal based on “Estimation STromal Immune MAlignant Tumours Expression data” algorithm represent levels cells. We found that were associated with poor prognosis ccRCC. To assess role ccRCC cells, first, performed differentially expressed genes analysis functional for validation. The results showed underlying mechanism...
Polycystic ovary syndrome (PCOS) is the most common hormonal disorder among reproductive-aged women worldwide, however, mechanisms and progression of PCOS still unclear due to its heterogeneous nature. Using human granulosa-like tumor cell line (KGN) mice model, we explored function lncRNA UCA1 in pathological PCOS.CCK8 assay Flow cytometry were used do cycle, apoptosis proliferation analysis, results showed that knockdown KGN cells inhibited by blocking cycle promoted apoptosis. In vivo...
Breast cancer (BC) is a malignant tumor with high morbidity and mortality, which seriously threatens women's health worldwide. Pyroptosis closely correlated immune landscape the tumorigenesis development of various cancers. However, studies about pyroptosis microenvironment in BC are limited. Therefore, our study aimed to investigate potential prognostic value pyroptosis-related genes (PRGs) their relationship BC. First, we identified 38 differentially expressed PRGs between normal tissues....
Periostin is an extracellular matrix protein that plays a critical role in cell fate determination and tissue remodeling, but the underlying mechanism of periostin diabetic cardiomyopathy (DCM) are far from clear. Thus, we aimed to clarify mechanistic participation DCM.The expression was examined DCM patients, mice high glucose (HG)-exposed cardiac fibroblasts (CF). Gain- loss-of-function experiments assessed potential pathogenesis. RNA sequencing used investigate mechanisms DCM.A mouse...