A5101615336- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Immune Cell Function and Interaction
- Cancer-related Molecular Pathways
- Nanoplatforms for cancer theranostics
- 3D Printing in Biomedical Research
- Neuroendocrine Tumor Research Advances
- Pancreatic function and diabetes
- Neutropenia and Cancer Infections
- Biochemical and Molecular Research
- Cancer Cells and Metastasis
- Antibiotic Resistance in Bacteria
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Nanoparticle-Based Drug Delivery
- Amino Acid Enzymes and Metabolism
- Advanced Nanomaterials in Catalysis
- Liver physiology and pathology
- Epigenetics and DNA Methylation
- Ear Surgery and Otitis Media
- Ferroptosis and cancer prognosis
Guizhou University
2024
Office of Science
2024
Center for Devices and Radiological Health
2024
United States Food and Drug Administration
2024
Eye & ENT Hospital of Fudan University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2015-2024
Ministry of Education of the People's Republic of China
2023-2024
Sichuan University
2023-2024
West China Second University Hospital of Sichuan University
2023-2024
Fudan University
2024
Abstract Oral administration is the most convenient and commonly used approach for drug delivery, while it still a challenge to overcome complicated gastrointestinal barriers realize efficient macromolecular absorption. Here, novel magneto‐responsive microneedle robots are presented oral delivery of versatile macromolecules. These with three components magnetic substrate, separable connection, tips generated by Lego‐brick‐stacking‐inspired multistage 3D fabrication strategy. With assistance...
IPF is characterized by fibroblast accumulation, collagen deposition, and ECM remodeling, with myofibroblasts believed to be the effector cell type. Myofibroblasts develop due EMT of lung alveolar epithelial cells, which can induced TGF-β. M2 macrophages, a macrophage subpopulation, secrete large amounts To clarify relationship between IPF, EMT, TGF-β, bleomycin-induced pulmonary fibrosis mouse model was used. Seventeen days after mice were treated bleomycin, successful establishment...
SIRT5 plays pleiotropic roles via post-translational modifications, serving as a tumor suppressor, or an oncogene, in different tumors. However, the role initiation and progression of pancreatic ductal adenocarcinoma (PDAC) remains unknown.
Microneedles are regarded as an emerging and promising transdermal drug delivery strategy. Great efforts devoted to getting rid of their material restrictions imparting them with abilities carry various drugs. Here, inspired by ice formation in nature based on characteristics different frozen materials, the authors present novel microneedles made from versatile soft materials using a simple freezing template-based fabrication stratagem for effective diverse actives. Their strategy can...
Cigarette smoking is a major pathogenic factor in lung cancer. Macrophages play an important role host defense and adaptive immunity. These cells display diverse phenotypes for performing different functions. M2 type macrophages usually exhibit immunosuppressive tumor-promoting characteristics. Although macrophage polarization toward the phenotype has been observed lungs of cigarette smokers, molecular basis process remains unclear. In this study, we evaluated possible mechanisms mouse that...
Worldwide, hepatocellular carcinoma (HCC) is one of the most common causes death in people. Albumin (ALB) considered as an important indicator for HCC prognosis, and evidence has shown cell growth can be regulated by ALB. However, role ALB hepatocarcinogenesis mechanism action still unknown. The expression was determined clinical profiles, immunohistochemistry, western blot. Wound healing Transwell assays were conducted to evaluate effects during migration invasion HCC. We used mass...
Abstract Nutritional factors play crucial roles in immune responses. The tumor-caused nutritional deficiencies are known to affect antitumor immunity. Here, we demonstrate that pancreatic ductal adenocarcinoma (PDAC) cells can suppress NK-cell cytotoxicity by restricting the accessibility of vitamin B6 (VB6). PDAC actively consume VB6 support one-carbon metabolism, and thus tumor cell growth, causing deprivation microenvironment. In comparison, NK require for intracellular glycogen...
Abstract Reactive oxygen species (ROS) have certain effect in cancer treatment, thus many studies been focused on developing functional systems to generate ROS tumor. Here, inspired by the multi‐enzyme biocatalysis organisms, novel ultrasound‐triggered temporospatial catalytic cascades are presented based barium titanate (BTO) and platinum (Pt) co‐loaded multi‐component microparticles (Pt/BTO@MCMPs) successively achieve production for tumor sonodynamic therapy. By using a customized...
Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide, prognosis of HNSCC remains bleak.Numerous studies revealed that tumor mutation burden (TMB) could predict survival outcomes a variety tumors.Objectives: This study aimed to investigate TMB immune infiltration in these patients construct an immune-related genes (IRGs) prognostic model.Methods: The expression data 546 were obtained from Cancer Genome Atlas (TCGA) database.All divided into...
Abstract Anticancer treatment is a worldwide challenge, and there are constant endeavors in this field to develop intelligent drug delivery systems improve the therapeutic effect. This paper presents novel ultrasound‐responsive microbubbles (UDMs), with chemotherapeutic‐encapsulated hydrogel shells gas cores. These developed using microfluidic electrospray treat pancreatic tumors. As composed of thermo‐sensitive poly(N‐isopropylacrylamide) (PNIPAM), they can contract under mild hyperthermia...
Artificial cilia actuators are described as responsive and actuatable cilia‐structured arrays that mainly made of flexible polymers. Over the past few decades, researchers have investigated features functions in nature, developed a vast number bio‐mimicked based on these findings. Nowadays, great progresses accomplished, including optimization fabrication methods, increase actuation approaches, promotion application fields. tailored to react magnetics, electrics, light, acoustics, heat, or...
Background:The prognostic nutritional index (PNI) is related to the prognosis of multiple malignancies.This study investigated whether PNI has value in advanced non-small cell lung cancer (NSCLC) patients treated with programmed death 1 (PD-1) inhibitors.Methods: We retrospectively analyzed NSCLC PD-1 inhibitors from July 2018 December 2019.Pretreatment was calculated by peripheral lymphocyte count and serum albumin level, cut-off determined.Subsequently, we relationship between early...
The introduction of immune-checkpoint blockade in the cancer therapy led to a paradigm change management late stage cancers. There are already multiple FDA approved checkpoint inhibitors and many other agents undergoing phase 2 early 3 clinical trials. therapeutic indication immune expanded last years, but still remains unclear who can benefit. MicroRNAs small RNAs with no coding potential. By complementary pairing 39 untranslated region messenger RNA, microRNAs exert posttranscriptional...
Abstract Background Bacterial infections are the most frequent complications in patients with malignancy, and epidemiology of nosocomial among cancer has changed over time. This study aimed to evaluate characteristics, antibiotic resistance patterns, prognosis due multidrug-resistant (MDR) bacteria patients. Methods retrospective observational analyzed caused by MDR from August 2013 May 2019. The extracted clinical data were recorded a standardized form compared based on survival status...
Liver plays a critical role in drug metabolism and nowadays multi-cellular culture systems aiming at imitating liver-specific morphology functionality are advancing robustly. Numerous immortalized or stem cell-induced hepatic cell lines have been investigated to enhance the phenotype establishing co-culture systems. Owing robust progresses of microtechnology bioengineering, two-dimensional (2D) co-cultures such as sandwich micropatterned emerged. Controllably arranging hepatocytes...
Immune checkpoint inhibitors (ICIs) have achieved acknowledged progress in cancer therapy. However, ICI-associated cardiotoxicity as one of the most severe adverse events is potentially life-threatening, with limited real-world studies reporting its predictive factors and prognosis. This study aimed to investigate incidence, risk factors, prognosis ICI-related patients advanced solid tumors.Electronic medical records from tumors receiving ICIs First Affiliated Hospital Xi'an Jiaotong...
Programmed death ligand 1 (PD-L1) plays an important role in the occurrence of hepatocellular carcinoma (HCC). The present study indicated that epithelial-mesenchymal transition (EMT) and induction cancer stem cell (CSC)-like properties contribute to metastasis cancers. However, molecular mechanisms underlying PD-L1 EMT CSC phenotypes HCC remain be elucidated. Here, we report regulates not only but also stem-like liver cells. We observed high expression CD133+ CSCs CSC-enriched tumor...