A5044904222- Antibiotic Resistance in Bacteria
- Cancer-related molecular mechanisms research
- Neutropenia and Cancer Infections
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Advanced Photocatalysis Techniques
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Multiple Myeloma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Circular RNAs in diseases
- Oxidative Organic Chemistry Reactions
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- TiO2 Photocatalysis and Solar Cells
- Virus-based gene therapy research
- Cell Adhesion Molecules Research
- Surface Modification and Superhydrophobicity
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Extraction and Separation Processes
- Immunotherapy and Immune Responses
- Supercapacitor Materials and Fabrication
- Animal Virus Infections Studies
- Chemokine receptors and signaling
Southwest Petroleum University
2021-2025
First Affiliated Hospital of Xi'an Jiaotong University
2015-2024
First Affiliated Hospital of Fujian Medical University
2017-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2022-2024
Guizhou University
2022-2024
Fujian Medical University
2017-2024
Hunan University of Science and Technology
2021-2024
Shangrao Normal University
2022-2024
Sun Yat-sen University
2023
Sun Yat-sen University Cancer Center
2023
A newly emerged duck parvovirus, which causes beak atrophy and dwarfism syndrome (BADS) in Cherry Valley ducks, has appeared Northern China since March 2015. To explore the genetic diversity among waterfowl parvovirus isolates, complete genome of an identified isolate designated SDLC01 was sequenced analyzed present study. Genomic sequence analysis showed that shared 90.8%–94.6% nucleotide identity with goose (GPV) isolates 78.6%–81.6% classical Muscovy (MDPV) isolates. Phylogenetic 443...
Rab31 belongs to the Ras superfamily of small GTP-binding proteins, which has been found regulate vesicle transport from Golgi apparatus early and late endosomes. The investigation here detected expression in 96 patients with hepatocellular carcinoma (HCC) tried identify its significance on outcome HCCs after liver resection. By immunohistochemistry staining, it was that HCC tissues remarkably higher than adjacent tissues. Aberrant overexpression identified be associated worse prognosis...
Chirality in biomolecules is ubiquitous our world, but oral nanomedicines constructed from chiral peptides are extremely rare, principally because of the immature nanofabrication and inadequate bioavailability nanostructures.Methods: To realize administration break through their forbidden zone intracellular space, a chiral-peptide supramolecular (DPAICP) camouflaging with membrane milk-derived extracellular vesicles (ME) was developed herein an aqueous-based growth method peptide Au(I)...
Background: Lung adenocarcinoma (LUAD) remains a lethal disease worldwide, with numerous studies exploring its potential prognostic markers using traditional RNA sequencing (RNA-seq) data. However, it cannot detect the exact cellular and molecular changes in tumor cells. This study aimed to construct model for LUAD single-cell RNA-seq (scRNA-seq) Methods: Bulk data were downloaded from The Cancer Genome Atlas (TCGA) database. scRNA-seq acquired Gene Expression Omnibus (GEO) uniform manifold...
Since June 2015, a highly pathogenic disease occurred in duck flocks China, causing pericardial effusion, enlarged discoloured liver, renal enlargement and haemorrhagic lung with mortality ranging from 5% to 20%. Previous study confirmed that Fowl adenovirus group C (FAdV-C) some field FAdVs isolates had been identified as causative agents of hydropericardium hepatitis syndrome (HHS) chickens geese world widely. In this study, we firstly report the isolation FAdV-C ducks HHS. The two...
Accumulating evidence has indicated that long noncoding RNAs (lncRNAs) play pivotal roles in the processes of cancer occurrence, progression, and treatment. FAM83A-AS1 is a novel onco-lncRNA involved various cancers. Nevertheless, biological function underlying mechanism lung adenocarcinoma (LUAD) remain largely unclear. In this study, we found to be upregulated LUAD tissues closely associated with tumor size, lymph node metastasis, TNM stage. addition, high expression correlated positively...
Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide, prognosis of HNSCC remains bleak.Numerous studies revealed that tumor mutation burden (TMB) could predict survival outcomes a variety tumors.Objectives: This study aimed to investigate TMB immune infiltration in these patients construct an immune-related genes (IRGs) prognostic model.Methods: The expression data 546 were obtained from Cancer Genome Atlas (TCGA) database.All divided into...
Abstract In nature, cells rely on a structural framework called the “cytoskeleton” to maintain their shape and polarity. Based this, herein new class of cell‐mimicking nanomedicine using bionic skeletons constituted by oligomeric Au(I)–peptide complex is developed. The peptide function degrading pathological MDM2 MDMX used synthesize an Au(I)–PMIV precursor capable self‐assembling into clustered spherical skeleton. Through coating erythrocyte membrane, erythrocyte‐mimicking nano‐cell...
Background:The prognostic nutritional index (PNI) is related to the prognosis of multiple malignancies.This study investigated whether PNI has value in advanced non-small cell lung cancer (NSCLC) patients treated with programmed death 1 (PD-1) inhibitors.Methods: We retrospectively analyzed NSCLC PD-1 inhibitors from July 2018 December 2019.Pretreatment was calculated by peripheral lymphocyte count and serum albumin level, cut-off determined.Subsequently, we relationship between early...
Abstract Background Bacterial infections are the most frequent complications in patients with malignancy, and epidemiology of nosocomial among cancer has changed over time. This study aimed to evaluate characteristics, antibiotic resistance patterns, prognosis due multidrug-resistant (MDR) bacteria patients. Methods retrospective observational analyzed caused by MDR from August 2013 May 2019. The extracted clinical data were recorded a standardized form compared based on survival status...
Emerging protein-protein interaction (PPI) modulators have brought out exciting ability as therapeutics in human diseases, but its clinical translation has been greatly hampered by the limited affinity. Inspired homodimerize structure of antibody, homodimerization contributes hugely to generating optimized affinity is conjectured. Herein, a statistical-mechanics-theory-guided method established quantize ligands with different topologies through analyzing change enthalpy and loss...
Immune checkpoint inhibitors (ICIs) have achieved acknowledged progress in cancer therapy. However, ICI-associated cardiotoxicity as one of the most severe adverse events is potentially life-threatening, with limited real-world studies reporting its predictive factors and prognosis. This study aimed to investigate incidence, risk factors, prognosis ICI-related patients advanced solid tumors.Electronic medical records from tumors receiving ICIs First Affiliated Hospital Xi'an Jiaotong...
Abstract The amplification of MET is a major cause acquired resistance to targeted therapy in EGFR‐mutant non‐small‐cell lung cancer (NSCLC), only be temporarily restrained by the partial efficacy inhibitors. This study reveals that inhibitor has unexpectedly limited due amplified triggering strong positive feedback loop Wnt/β‐catenin signaling pathway, allowing optimal functionality even when pathway suppressed again. To test this conjecture and specifically target cleverly designed Wnt...
With appropriate cerium (Ce) doping, the layered lithium ion-sieve precursor Li1.37Ce0.001Mn1.22O3 was synthesized using hydrothermal and solid-phase calcination, which exhibited Li/Mn ratio exceeding 1, indicating a high theoretical adsorption capacity. The incorporation of Ce further stabilized spatial configuration controlled dissolution loss manganese (Mn) to approximately 0.55%. At 25°C, with pH 9 initial lithium-containing solution concentration 100 mg/L, capacity can reach around 33...