With the development of new energy powered vehicles, shortage lithium resources has become more urgent. The recovery and extraction from waste iron phosphate batteries...

A variety of miRNAs have been recently reported to be abnormally expressed in colorectal cancer (CRC). growing number studies demonstrated that aberrantly are closely related the development and progression CRC. It has found miR-140-3p plays a vital role several cancers. However, its expression, roles mechanisms CRC remain unknown.Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) were used determine expression tissues cell lines. CCK8, migration, invasion flow cytometric...

An injectable hydrogel via hydrazone cross-linking was prepared under mild conditions without addition of cross-linker or catalyst. Hydrazine and aldehyde modified poly(aspartic acid)s were used as two gel precursors. Both them are water-soluble biodegradable polymers with a protein-like structure, obtained by aminolysis reaction polysuccinimide. The latter can be thermal polycondensation aspartic acid. Hydrogels in PBS solution characterized different methods including content swelling,...

Oral squamous cell carcinoma (OSCC) is the most frequent oral malignancy. Recent studies have revealed that long non-coding RNA (lncRNA) PVT1 plays important roles in pathogenesis of various cancers. However, functional OSCC progression and cisplatin resistance not been elucidated.In this study, expression level cisplatin-sensitive cisplatin-resistant tissues lines was determined using qRT-PCR. Gain-of-function loss-of-function assays were performed to explore biological proliferation...

Programmed cell death 1 ligand (PD-L1) blockade has been used therapeutically in the treatment of ovarian cancer, and potential combination approaches are under investigation to improve response rate. The increased dependence on glutamine is widely observed various type tumors, including cancer. Kidney-type glutaminase (GLS), as one isotypes glutaminase, found promote tumorigenesis. Here, we have demonstrated that combined with GLS inhibitor 968 PD-L1 enhances immune against Survival...

Immune checkpoint inhibitors (ICIs) have achieved acknowledged progress in cancer therapy. However, ICI-associated cardiotoxicity as one of the most severe adverse events is potentially life-threatening, with limited real-world studies reporting its predictive factors and prognosis. This study aimed to investigate incidence, risk factors, prognosis ICI-related patients advanced solid tumors.Electronic medical records from tumors receiving ICIs First Affiliated Hospital Xi'an Jiaotong...

Abstract Introduction: The mechanisms of action cytotoxic monoclonal antibodies (mAbs) include FcγR-dependent to induce antibody-dependent cell cytotoxicity (ADCC). In mice, ADCC relies on mFcγRIII expressed NK cells, while human cells depend hFcγRIIIA (hCD16A). However, IgG1 display significant affinity differences between mouse and FcγRs, which can impact their efficacy in preclinical models. Additionally, testing an affinity-enhanced Fc-engineered antibody a without the FcγR counterparts...

Abstract Introduction: Antibody-drug conjugates (ADCs) represent a breakthrough therapeutic class that provides tumor-targeted cytotoxicity while stimulating immune responses, offering promising potential when combined with immunotherapies and particularly PD-1 inhibitors. Traditional xenograft tumor models developed in immunodeficient mice are employed to evaluate ADCs' anti-tumor efficacy. However, these lack competent systems human antigen expression normal tissues, limiting their...

Blockade of the programmed cell death 1(PD-1)/PD-1 ligand-1(PD-L1) pathway has been exploited therapeutically in many cancer types. Upregulation PD-L1 tumor cells contributes to malignancy through suppression T cell-mediated antitumor response. Pyruvate dehydrogenase kinase 1 (PDK1), a glycolytic gate-keeping enzyme, is also known promote development. Here, we have uncovered mechanism regulation by PDK1 activation c-Jun-NH2-kinase (JNK)-c-Jun ovarian cells. Elevated expression was correlated...

Objective Cell death‐inducing DFF45‐like effector C (CIDEC) is a lipid droplet‐coating protein that promotes triglyceride accumulation and inhibits lipolysis. TNF‐α downregulates CIDEC levels to enhance basal lipolysis, whereas overexpression could block this effect. This study aimed investigate the signaling pathway of TNF‐α‐mediated downregulation in human adipocytes. Methods First expression was detected adipose tissue lean subjects with obesity. Next, temporal‐ dose‐dependent effects on...

Cutaneous melanoma is a highly malignant skin tumor, and most patients have poor prognosis. In recent years, immunotherapy has assumed an important role in the treatment of advanced cutaneous melanoma, but only small percentage benefit from immunotherapy. A growing number studies demonstrated that prognosis with closely related to long non-coding RNA tumor immune microenvironment.We downloaded expression data immune-related gene lists separately The Cancer Genome Atlas database ImmPort...

The biodegradation rates of carbon nanotube (CNT)/ polymer nanocomposites (PNCs) containing poly-ε-caprolactone (PCL) were investigated using Pseudomonas aeruginosa, a microorganism commonly found in the environment. CNT/PCL nanocomposite mass loss profiles revealed that rate PCL matrix decreased systematically as CNT loading increased from 0.1 to 10% w/w. Addition even low (<1% w/w) caused constant decrease by more than 50%. Similar trends observed for both pristine and oxidized multiwall...

Although predictive markers of immune checkpoint inhibitor (ICI)-based treatments have been extensively studied, with the exception programmed death ligand 1 (PD-L1), most are not widely used in clinic due to poor effects or defective practicability. The aim this study was identify those patients high baseline serum cholesterol who benefit from ICI-based treatments.Patients advanced non-small cell lung cancer (NSCLC) treated at Ningbo Medical Center, Li Huili Hospital between August 2017 and...

Cervical cancer is a highly prevalent female malignancy. Presently, cisplatin (DDP) first-line agent for cervical chemotherapy. However, its curative effect limited because of chemo-resistance. It has been previously reported that SOX9 targeted and activated oncogenic genes, enhancing cell resistance to DDP. The effects the SOX9/lncRNA ANXA2P2/miR-361-3p/SOX9 regulatory loop on growth DDP have demonstrated. miR-361-3p expression was decreased in DDP-resistant cells tissues. Moreover,...

Hydroxysafflor yellow A (HSYA) is a water-soluble component of the safflower (Carthamus tinctorius), and research has revealed that HSYA exhibits antitumor effects. In present study, effects on autophagy Hep-G2 liver cancer cell line, as well underlying mechanisms, were investigated. cells treated with viability was measured using an MTT assay. Western blotting immunofluorescence assays performed to determine expression light chain 3 II (LC3-II) p62, regulators Beclin 1 ERK1/2. Transmission...

Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal tumors, but targeted therapies showed no efficacy non-selected patients. This study aims at investigating the adaptive cetuximab subset a cohort of squamous cell carcinoma (ESCC) patient-derived xenografts (PDXs).A large panel ESCC PDXs has been established. The copy number, mRNA expression and immunohistochemistry (IHC) key EGFR pathways have examined along with response. A preclinical trial on randomly...

Neocarzinostatin (NCS) is a member of enediyne antibiotics with high anticancer potential. Our study was performed to explore the synergistic anti-glioma effects NCS and paclitaxel (PTX) in vitro vivo. By 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, cytotoxicities drugs human glioma cells U87MG rat C6 were evaluated. The results showed that combinations PTX can synergistically inhibit survival. Cell apoptosis detected by flow cytometry, enhanced ratio cells....

Despite recent advances in treatment, overall survival rates for metastatic melanoma, especially those that invade the lungs, continue to be low, with 5-year of only 3% 5%. It was recently discovered Wnt/β-catenin signaling pathways and MAPK/ERK are involved melanoma metastasis.

Cervical cancer (CC) remains a major health concern globally, much of the brunt which is experienced by low- and middle-income countries where screening in terms cytology DNA genotyping for high-risk oncogenic subtypes human papilloma virus (hr-HPV) either inadequate or performed rather late. In this study, we aimed to determine biomarkers panels that are capable diagnosing precancerous cervical intraepithelial neoplasia (CIN) stages from healthy CC patients via untargeted gas...

Currently, tumor-infiltrating lymphocytes (TILs) in invasive breast cancers are assessed solely on the basis of their number, whereas spatial distribution is rarely investigated. Therefore, we evaluated TILs 579 patients with cancer no special type (IBC-NST) a focus distributions tumor center (TC) and margin (IM). We also new factor, namely para-tumor infiltrating (PILs) lobular area (Para). Five immunoarchitectural patterns (IPs) were observed, which significantly associated...