A5100450757- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Antibiotics Pharmacokinetics and Efficacy
- Microbial infections and disease research
- MicroRNA in disease regulation
- Metabolomics and Mass Spectrometry Studies
- interferon and immune responses
- Nanoplatforms for cancer theranostics
- Neonatal Health and Biochemistry
- Immunotherapy and Immune Responses
- Plant-derived Lignans Synthesis and Bioactivity
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Pharmacogenetics and Drug Metabolism
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Circular RNAs in diseases
- Angiogenesis and VEGF in Cancer
- Histone Deacetylase Inhibitors Research
- RNA Research and Splicing
- Streptococcal Infections and Treatments
- Dielectric materials and actuators
Qingzhou City People's Hospital
2025
Second Affiliated Hospital of Nanjing Medical University
2024
Jilin Academy of Agricultural Sciences
2024
Huzhou Central Hospital
2023
Hebei Medical University
2022-2023
Children's Hospital of Chongqing Medical University
2022
Chongqing Medical University
2020-2022
Affiliated Hospital of Taishan Medical University
2022
Shandong First Medical University
2022
ZheJiang Institute For Food and Drug Control
2022
Bone marrow mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs) have been widely used for treating myocardial infarction (MI). However, low retention and short-lived therapeutic effects are still significant challenges. This study aimed to determine whether incorporation of MSC-derived sEVs in alginate hydrogel increases their the heart thereby improving effects. Methods: The optimal sodium incorporating system was determined by its release ability rheology hydrogel. Ex...
Background: Diabetes mellitus exacerbates myocardial ischemia/reperfusion (MI/R) injury by incompletely understood mechanisms. Adipocyte dysfunction contributes to remote organ injury. However, the molecular mechanisms linking dysfunctional adipocytes increased MI/R remain unidentified. The current study attempted clarify whether and how small extracellular vesicles (sEV) may mediate pathological communication between diabetic cardiomyocytes, exacerbating Methods: Adult male mice were fed a...
Allergic rhinitis (AR) is an inflammatory disorder of the upper airway. Exosomes or extracellular vesicles are nanosized endosomal origin released from and epithelial cells that have been implicated in allergic diseases. In this study, we characterized microRNA (miRNA) content exosomes AR.Extracellular were isolated nasal mucus healthy control subjects (n=10) patients with severe AR (n=10). Vesicle RNA was analyzed by using a TaqMan assays Human Panel-Early Access kit (Applied Biosystems,...
Non-small cell lung cancer is the most common type of with a poor prognosis, and development an effective diagnostic method urgently needed. Exosomal lncRNAs, class transcripts longer than 200 nucleotides packaged into exosomes, have been defined as ideal biomarker for cancer. However, little known about clinical utility exosomal lncRNAs in NSCLC. Here, we aimed to identify promising biomarkers NSCLC diagnosis. First, serum exosomes from patients were successfully isolated by polymer...
As endogenous courier vesicles, exosomes play crucial roles in macromolecule transmission and intercellular communication. Therefore, have drawn increasing attention as biomimetic drug-delivery vehicles over the past few years. However, studies investigated encapsulation of peptide/protein drugs into for oral administration. Additionally, mechanisms underlying their properties delivery remain unknown. Herein, insulin-loaded milk-derived (EXO@INS) were fabricated vivo hypoglycemic effect was...
We have previously shown that the inhibition of histone deacetylases (HDACs) protects heart against acute myocardial ischemia and reperfusion injury. also demonstrated HDAC stimulates myogenesis angiogenesis in a cultured embryonic stem cell model. investigate whether vivo preserves cardiac performance prevents remodeling mouse infarction (MI) through stimulation endogenous regeneration. MI was created by ligation left descending artery. Animals were divided into three groups: 1) sham group,...
Exosomes, a type of extracellular vesicle, have been shown to be involved in many disorders, including Alzheimer's disease (AD). Exosomes may contribute the spread misfolded proteins such as amyloid-β (Aβ) and α-synuclein. However, specific diffusion process exosomes their final destination brain are still unclear. In present study, we isolated from peripheral plasma injected them into hippocampus an AD mouse model, investigated exosome diffusion. We found that can dentate gyrus (DG) other...
Monocyte activation and tissue infiltration are quantitatively associated with high-salt intake induced target organ inflammation. We hypothesized that challenge would induce the expansion of CD14++CD16+ monocytes, one three monocyte subsets a pro-inflammatory phenotype, is inflammation in humans.
Exosomal long non-coding RNAs (lncRNAs) have emerged as a cell-free biomarker for clinical evaluation of cancers. However, the potential applications exosomal lncRNAs in acute myeloid leukemia (AML) remain unclear. Herein, we attempted to identify plasma prospective biomarkers AML. In this study, exosomes were first successfully extracted from AML patients and healthy donors (HD). Subsequently, downregulated (LINC00265, LINC00467, UCA1) upregulated lncRNA (SNHG1) identified (n=65) compared...
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Radiotherapy is one of the effective methods for treatment breast cancer; however, controversies still exist with respect to radiotherapy patients TNBC. Here, we intend explore mechanism by which local promotes recruitment M-MDSCs in lung and increases risk metastasis TNBC tumor-bearing mice.A single dose 20 Gy X-ray was used locally irradiate primary tumor 4T1 mice. Tumor growth, number pulmonary metastatic nodules, frequency MDSCs were monitored Antibody microarray ELISA analyze cytokines...
Alzheimer's disease (AD) is an incurable and irreversible neurodegenerative disease, without a clear pathogenesis. Therefore, identification of candidates before amyloid-β plaque (Aβ) deposition proceeds major significance for earlier intervention in AD.To explore the potential noninvasive biomarkers AD 5XFAD mouse model, microRNAs (miRNAs) from urinary exosomes 1-month-old pre-Aβ accumulation mice models their littermate controls were profiled by microarray analysis. The differentially...
Pterostilbene is a revesterol analog with long bioavailability and having potent anti-inflammatory activity in animal studies. In this study, we tried to scrutinize the anti-arthritic effect of pterostilbene against complete Freund's adjuvant (CFA)-induced arthritis model rats. CFA was used for induction RA, rats were divided into groups depending on different doses given. Hepatic, antioxidant, rheumatoid factor (RF), myeloperoxidase (MPO), inflammatory cytokines, anti-collagen(C)II-Ig,...