A5049073234- Bone Tissue Engineering Materials
- Calcium Carbonate Crystallization and Inhibition
- Dental materials and restorations
- Bone and Dental Protein Studies
- Diatoms and Algae Research
- Paleontology and Stratigraphy of Fossils
- Dental Erosion and Treatment
- Minerals Flotation and Separation Techniques
- Crystallization and Solubility Studies
- Polymer Surface Interaction Studies
- Bacteriophages and microbial interactions
- Nanoplatforms for cancer theranostics
- Endodontics and Root Canal Treatments
- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- Bone health and osteoporosis research
- biodegradable polymer synthesis and properties
- Bone health and treatments
- RNA Interference and Gene Delivery
- nanoparticles nucleation surface interactions
- Advanced Nanomaterials in Catalysis
- Cephalopods and Marine Biology
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Cancer Research and Treatments
Zhejiang University
2016-2025
Sir Run Run Shaw Hospital
2022-2024
Hangzhou Xixi hospital
2013-2024
State Key Laboratory of Silicon Materials
2010-2024
East China Normal University
2022
Hangzhou Academy of Agricultural Sciences
2015-2020
Zhejiang Academy of Social Sciences
2016
Shanghai Normal University
2015
Institute of Microbiology
2010-2012
Zhejiang Sci-Tech University
2008-2009
Hydroxyapatite (HAP) nanoparticles, typically 20 ± 5, 40 10 and 80 12 nm in diameter, were prepared their effects on the proliferation of two bone-related cells, bone marrow mesenchymal stem cells (MSCs) osteosarcoma (U2OS) studied. The cell culture experiments showed improved cytophilicity nanophase mineral as compared with conventional HAP. Greater viability MSCs measured nano HAP, remarkably for sized particles. Interestingly, growth was inhibited by HAP particles best retardant. It is...
Recent developments in biomineralization and biomaterials have demonstrated that nano-calcium phosphate particles play an important role the formation of hard tissues nature. It is suggested basic inorganic building blocks bone enamel are nanosized apatite although their hierarchical structures differ. Nanoparticles can confer on biominerals remarkable physical chemical characteristics such as enhanced mechanical strength self-preservation biological fluids. In living organisms, tens to...
The regeneration of tooth enamel, the hardest biological tissue, remains a considerable challenge because its complicated and well-aligned apatite structure has not been duplicated artificially. We herein reveal that rationally designed material composed calcium phosphate ion clusters can be used to produce precursor layer induce epitaxial crystal growth enamel apatite, which mimics biomineralization crystalline-amorphous frontier hard tissue development in nature. After repair, damaged...
Bone marrow mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs) have been widely used for treating myocardial infarction (MI). However, low retention and short-lived therapeutic effects are still significant challenges. This study aimed to determine whether incorporation of MSC-derived sEVs in alginate hydrogel increases their the heart thereby improving effects. Methods: The optimal sodium incorporating system was determined by its release ability rheology hydrogel. Ex...
Biological hard tissues such as bones always contain extremely high levels of citrate, which is believed to play an important role in bone formation well osteoporosis treatments. However, its mechanism on biomineralization not elucidated. Here, it found that the adsorbed citrate molecules collagen fibrils can significantly reduce interfacial energy between biological matrix and amorphous calcium phosphate precursor enhance their wetting effect at early stage, sequentially facilitating...
Insufficient intracellular anabolism is a crucial factor involved in many pathological processes the body
Abstract Biomineralization is the intricate process by which living organisms orchestrate formation of organic–inorganic composites regulating nucleation, orientation, growth, and assembly inorganic minerals. As our comprehension biomineralization principles deepens, novel strategies for fabricating materials based on these have emerged. Researchers can also harness to tackle challenges in both materials' science biomedical fields, demonstrating a thriving research field. This review begins...
Inspired by eggshells in nature, living yeast cells were conferred with an artificial mineral coat using a combination of the layer-by-layer (LBL) treatment functional polymers and situ biomimetic mineralization. The resulting hard inorganic shells have tremendous effect on storage, protection, delivery, modification cells.
The biomedical materials research community frequently accepts that amorphous calcium phosphate (ACP) can be adsorbed and assimilated more readily by living organisms to produce new bone tissue than crystallized phosphates such as hydroxyapatite (HAP). Previous studies also confirm ACP has improved bioactivity compared HAP since adhesion proliferation of osteogenic cells are observed on the substrates. However, we note different size -effects not taken into account in these used always...
Hollow-structured calcium phosphate nanospheres can be transferred into pin-shaped crystallites under the ultrasonic treatments, release of encapsulated compounds on/off triggered, and its kinetics is precisely regulated by power density, duty cycle, application time ultrasound.
Magnesium ions (Mg2+) are widely present in biological fluids, and they suggested as the vital factors that inhibit spontaneous hydroxyapatite (HAP) precipitation nature. However, regulation mechanisms of Mg2+ on HAP crystallization still under intensive debates. We find a typical from supersaturated solutions should include five stages: s1, formation ion clusters amorphous calcium phosphate (ACP); s2, stabilization ACP; s3, transformation ACP to via dissolution crystallization; s4,...
Potential mechanisms for formation of highly organized biomineralized structures include oriented crystal growth on templates, the aggregation nanocrystals by attachment, and assembly inorganic nanoparticles mediated organic molecules into aggregated structures. In present study, potential role amorphous calcium phosphate (ACP) in facilitating hydroxyapatite (HAP) ordered was evaluated. The physical characteristics HAP prepared three different methods were analyzed after extended exposure to...
The development of vaccines against infectious diseases represents one the most important contributions to medical science. However, vaccine-preventable still cause millions deaths each year due thermal instability and poor efficacy vaccines. Using human enterovirus type 71 vaccine strain as a model, we suggest combined, rational design approach improve thermostability immunogenicity live by self-biomineralization. biomimetic nucleating peptides are rationally integrated onto capsid reverse...
Graphene oxide (GO) can efficiently capture viruses, destroy their surface proteins, and extract viral RNA in an aqueous environment by using the superficial bioreduction of GO. It follows from these phenomena that GO is excellent nanomaterial for high-throughput detection disinfection demonstrating its great potential prevention environmental infections. As a service to our authors readers, this journal provides supporting information supplied authors. Such materials are peer reviewed may...
Many animals such as crustacean periodically undergo cyclic molt of the exoskeleton. During this process, amorphous calcium mineral phases are biologically stabilized by magnesium and reserved for subsequent rapid formation new shell tissue. However, it is a mystery how living organisms can regulate transition precursor precisely. We reveal that mineralization from precursors associated with presence Asp-rich proteins. It suggested cooperative effect compound result into crystallization...
A biomimetic construction of enamel-like apatite material is achieved by the cooperation nanoparticles and Glu on enamel substrate under physiological conditions; artificial layer shares exactly same crystallographic tectonic properties with natural enamel; apparent restoration hardness particularly significant. We suggest a biomineralization-inspired strategy to approach biomaterials optimal characteristics. Detailed facts importance specialist readers are published as "Supporting...
Herein, we propose a drug-free approach to cancer therapy that involves cell targeting calcification (CCTC). Several types of cells, such as HeLa characterized by folate receptor (FR) overexpression, can selectively adsorb (FA) molecules and then concentrate Ca(2+) locally induce specific calcification. The resultant calcium mineral encapsulates the inducing their death, in vivo assessments confirm CCTC treatment efficiently inhibit tumor growth metastasis without damaging normal cells...
Organisms use inorganic ions and macromolecules to regulate crystallization from amorphous precursors, endowing natural biominerals with complex morphologies enhanced properties. The mechanisms by which modifiers enable these shape-preserving transformations are poorly understood. We used in situ liquid-phase transmission electron microscopy follow the evolution calcium carbonate calcite presence of additives. A combination contrast analysis infrared spectroscopy shows that Mg ions, widely...
Abstract Osteoporosis is an incurable chronic disease characterized by a lack of mineral mass in the bones. Here, full recovery osteoporotic bone achieved using calcium phosphate polymer‐induced liquid‐precursor (CaP‐PILP). This free‐flowing CaP‐PILP material displays excellent inductivity and able to readily penetrate into collagen fibrils form intrafibrillar hydroxyapatite crystals oriented along c ‐axis. ability attributed microstructure material, which consists homogeneously distributed...