A5101834668- Dental materials and restorations
- Dental Erosion and Treatment
- Endodontics and Root Canal Treatments
- Bone Tissue Engineering Materials
- Bone and Dental Protein Studies
- Calcium Carbonate Crystallization and Inhibition
- Oral microbiology and periodontitis research
- Advanced X-ray and CT Imaging
- Dental Research and COVID-19
- Medical Imaging Techniques and Applications
- Orthodontics and Dentofacial Orthopedics
- Photonic and Optical Devices
- Crystallization and Solubility Studies
- Radiation Dose and Imaging
- Airway Management and Intubation Techniques
- X-ray Diffraction in Crystallography
- Dental Anxiety and Anesthesia Techniques
- Thyroid and Parathyroid Surgery
- Nuclear Physics and Applications
- Plasmonic and Surface Plasmon Research
- Collagen: Extraction and Characterization
- Intermetallics and Advanced Alloy Properties
- Neuropeptides and Animal Physiology
- Polymer Surface Interaction Studies
- Veterinary Orthopedics and Neurology
Zhejiang University
2014-2025
Stomatology Hospital
2014-2025
Nanjing General Hospital of Nanjing Military Command
2023
Nanjing University
2013-2023
Shanxi Medical University
2022
Tsinghua University
2013-2022
Guangzhou Medical University
2021-2022
Hangzhou Academy of Agricultural Sciences
2020
Hangzhou Xixi hospital
2018
Nanyang Technological University
2014-2016
The regeneration of tooth enamel, the hardest biological tissue, remains a considerable challenge because its complicated and well-aligned apatite structure has not been duplicated artificially. We herein reveal that rationally designed material composed calcium phosphate ion clusters can be used to produce precursor layer induce epitaxial crystal growth enamel apatite, which mimics biomineralization crystalline-amorphous frontier hard tissue development in nature. After repair, damaged...
Biological hard tissues such as bones always contain extremely high levels of citrate, which is believed to play an important role in bone formation well osteoporosis treatments. However, its mechanism on biomineralization not elucidated. Here, it found that the adsorbed citrate molecules collagen fibrils can significantly reduce interfacial energy between biological matrix and amorphous calcium phosphate precursor enhance their wetting effect at early stage, sequentially facilitating...
Rapid biomimetic intrafibrillar mineralization of collagen was induced by polyelectrolyte–calcium complexes as a pre-precursor.
Abstract Dentin hypersensitivity (DH) is triggered by external stimuli irking fluid flow through exposed dentinal tubules (DTs). Three commercially available desensitizing agents as control in this study only achieve limited occlusion depths of ≈10 µm the DTs well scarce remineralization demineralized dentin matrix. Herein, polyelectrolyte‐calcium complexes pre‐precursor (PCCP) process proposed for managing DH that with rubbed ultrahighly concentrated suspension (4 g L −1 ‐5.44 m ) followed...
We propose a novel fluorescent adhesive-assisted biomimetic mineralization strategy, based on mild self-etch adhesive containing 25 wt% polyacrylic acid-stabilized amorphous calcium phosphate nanoparticles and 1 sodium fluorescein.
Lab biomineralization should be carried out in an actual clinical practice. This study evaluated self-etch adhesive as a carrier for amorphous calcium phosphate (ACP) nanoprecursors to continuously deliver biomimetic remineralization of self-assembly type I collagen and demineralized dentin. Si-containing ACP particles (Si-ACP) stabilized with polyaspartic acid (PAsp) were synthesized characterized by transmission electron microscopy (TEM), scanning microscopy–energy-dispersive X-ray...
Root fractures often occur in immature maxillary permanent central incisors and can be combined with other injuries, making treating more difficult prognosis uncertain. A 10-year-old girl sustaining a second dental trauma came to our hospital. Teeth 11 21 experienced root fracture following the first injury 15 months earlier. The resulted lateral luxation of coronal fragment Tooth from original site subluxation 21. was repositioned, both were splinted for 3 months. An apical plug applied at...
Optical fiber based surface plasmon resonance (SPR) sensors are favored by their high sensitivity, compactness, remote and in situ sensing capabilities. Microstructured optical fibers (MOFs) possess microfluidic channels extended along the entire length right next to core, thereby enabling infiltrated biochemical analyte access evanescent field of guided light. Since SPR can only be excited polarization vertical metal surface, external perturbation could induce crosstalk thus leading...
Abstract Demineralization of hard tooth tissues leads to dental caries, which cause health problems and economic burdens throughout the world. A biomimetic mineralization strategy is expected reverse early caries. Commercially available anti-carious mineralizing products lead inconclusive clinical results because they cannot continuously replenish required calcium phosphate resources. Herein, we prepared a film consisting hydroxypropylmethylcellulose (HPMC) polyaspartic acid-stabilized...
As the sixth leading cause of cancer death, esophageal is threatening life people worldwide. Traditional treatments, such as surgery, chemotherapy, radiotherapy, are facing always augmented challenges including invasion, multidrug resistance (MDR), off-target toxicity. Chemo & Photodynamic synergistic therapy represents one promising strategy for improved treatment efficiency. But it still hindered by lack tumor targeting, deleterious side effects, and unfavorable microenvironment...
Dentin hypersensitivity is attributable to the exposed dentin and its patent tubules. We proposed therapeutic management of demineralized surfaces using a mineralizing adhesive seal remineralize dentin, dentinal tubules, odontoblast processes. An experimental self-etch consisting 20 wt % poly-aspartic acid-stabilized amorphous calcium phosphate (PAsp-ACP) nanoparticles were prepared characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, transmission...
Numerous small biomolecules exist in the human body and play roles various biological pathological processes. Small molecules are believed not to induce intrafibrillar mineralization alone. They required work synergy with noncollagenous proteins (NCPs) their analogs,
Methacryloyloxydecyl dihydrogen phosphate (MDP) has been speculated to induce mineralization, but there no convincing evidence of its ability intrafibrillar mineralization. Polymers play a critical role in biomimetic mineralization as stabilizers/inducers amorphous precursors. Hence, MDP-induced without polymer additives not fully verified or elucidated. By combining 3-dimensional stochastic optical reconstruction microscopy, surface zeta potentials, contact angle measurements, inductively...
The phosphorylated noncollagenous proteins (NCPs) play a vital role in manipulating biomineralization, while the mechanism of phosphorylation NCPs intrafibrillar mineralization collagen fibril has not been completely deciphered. Poly(vinylphosphonic acid) (PVPA) and sodium trimetaphosphate (STMP) as templating analogs induce hierarchical cooperation with indispensable sequestration such polyacrylic acid (PAA) via polymer-induced liquid-like precursor (PILP) process. Herein, STMP-Ca PVPA-Ca...
We propose the asymmetrical plasmonic slot waveguide (APSW) design for third-harmonic generation (THG) from 2.25 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\mu\hbox{m}$</tex></formula> . In this configuration, phase-matching condition is fulfilled between zeroth-order mode at fundamental frequency (FF) and first-order (THF). Due to geometry, overlap two involved modes significantly enhanced,...
This study investigated the effects of mineralizing film consisting hydroxypropyl methylcellulose (HPMC) and amorphous fluorinated calcium phosphate (AFCP) nanoparticles on enamel white spot lesions (WSLs).The AFCP were prepared via nanoprecipitation solvent evaporation, respectively. They characterized with Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), transmission electron microscopy (TEM), selected area (SAED), scanning (SEM), energy-dispersive (EDX),...