A5085747337- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Atherosclerosis and Cardiovascular Diseases
- Dental Erosion and Treatment
- Single-cell and spatial transcriptomics
- Complementary and Alternative Medicine Studies
- RNA modifications and cancer
- Dental materials and restorations
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Endodontics and Root Canal Treatments
- Acupuncture Treatment Research Studies
- nanoparticles nucleation surface interactions
- Ferroptosis and cancer prognosis
- Phosphodiesterase function and regulation
- Cancer, Hypoxia, and Metabolism
- Calcium Carbonate Crystallization and Inhibition
- Renal function and acid-base balance
- Cardiac Ischemia and Reperfusion
- Hepatitis Viruses Studies and Epidemiology
- Coronary Artery Anomalies
- Electrophoretic Deposition in Materials Science
- Acute Myocardial Infarction Research
- Pulmonary Hypertension Research and Treatments
- Epigenetics and DNA Methylation
First Hospital of Jiaxing
2018-2024
Jiaxing University
2017-2024
Zhejiang University
2016-2022
Hubei University of Science and Technology
2018-2022
Shenzhen Sixth People's Hospital
2020
Wuxi People's Hospital
2018
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2016
Zhejiang Academy of Medical Sciences
2014
Osteoporosis is a global chronic disease characterized by severe bone loss and high susceptibility to fragile fracture. It widely accepted that the origin acidified microenvironment created excessive osteoclasts causes irreversible mineral dissolution organic degradation during osteoclastic resorption. However, current clinically available approaches are mainly developed from perspective of osteoclast biology rather than critical niche. Here, we smart "nanosacrificial layer" consisting...
Some tumor cells have a high rate of glutamine uptake and exhibit addiction. Alanine-serine cysteine-preferring transporter 2 (ASCT2) is major mediator supply in many cells, but the underlying effects mechanisms ASCT2 pancreatic cancer (PC) are largely unknown. Our results show that expression significantly higher PC than normal duct pancreas. Utilizing Kaplan-Meier Plotter database, SLC1A5 mRNA was associated with poor overall survival (OS) patients PC. shRNA-mediated inhibition function...
MicroRNAs (miRNAs) have an important role in the regulation of tumor development and metastasis. In this study, we investigated clinical prognostic value as well biological function miR-466 colorectal cancer (CRC). Tumor adjacent healthy tissues were obtained from 100 patients diagnosed with CRC. expression was determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR). mRNA protein levels cyclin D1, apoptosis regulator BAX (BAX), matrix metalloproteinase-2 (MMP-2)...
Abstract It has been shown that circRNAs are involved in the development of heart diseases. However, few studies explored role acute myocardial infarction (AMI). The present study aims to investigate circ_0060745 pathogenesis AMI. We found expression was significantly increased myocardium AMI mice and mainly expressed fibroblasts. knockdown decreased infarct size improved systolic cardiac functions after fibroblasts inhibited migration peritoneal macrophage, apoptosis cardiomyocytes...
Dentin hypersensitivity is attributable to the exposed dentin and its patent tubules. We proposed therapeutic management of demineralized surfaces using a mineralizing adhesive seal remineralize dentin, dentinal tubules, odontoblast processes. An experimental self-etch consisting 20 wt % poly-aspartic acid-stabilized amorphous calcium phosphate (PAsp-ACP) nanoparticles were prepared characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, transmission...
Abstract Background Pulmonary arterial hypertension is a common complication in patients with congenital heart disease. In the absence of early diagnosis and treatment, pediatric PAH has poor survival rate. Here, we explore serum biomarkers for distinguishing children pulmonary associated disease (PAH-CHD) from CHD. Methods Samples were analyzed by nuclear magnetic resonance spectroscopy-based metabolomics 22 metabolites further quantified ultra-high-performance liquid chromatography–tandem...
MicroRNAs are widely involved in the pathogenesis of cardiovascular diseases through regulating gene expression via translational inhibition or degradation their target mRNAs. Recent studies have indicated a critical role microRNA-206 myocardial ischaemia-reperfusion (I/R) injury. However, function miR-206 I/R injury is currently unclear. The present study was aimed to identify specific and explore underlying molecular mechanism. Our results revealed that level significantly decreased both...
Although ultra-small nanoclusters (USNCs, < 2 nm) have immense application capabilities in biomedicine, the investigation on body-wide organ responses towards USNCs is scant. Here, applying a novel strategy of single-cell mass cytometry combined with Nano Genome Atlas multi-tissues, we systematically evaluate interactions between host and calcium phosphate (CaP) at organism level. Combining cytometry, magnetic luminex assay results, identify dynamic immune to CaP single cell resolution. The...
Abstract Crystallization by particle attachment is widely observed in both natural and synthetic environments. Although this form of nonclassical crystallization generally described oriented attachment, random aggregation building blocks to give single‐crystal products also observed, but the mechanism crystallographic realignment unknown. We herein reveal that during aggregation‐based growth initially produces a nonoriented front. Subsequent evolution orientation driven inherent surface...
Objective . To investigate the protective effect of miR‐542‐3p on cardiomyocyte injury and related mechanisms. Methods A hypoxia/reoxygenation model was established. The expression levels PDE4D were detected using qRT‐PCR; luciferase reporter assay system used to detect targeting relationship between PDE4D; overexpressing transfected into cardiomyocytes, ROS release by immunofluorescence while cellular apoptosis TUNEL; western blot applied PDE4D, phosphorylated protein kinase (p‐PKA), cyclic...
Patients diagnosed with cancer face an increased risk of cardiovascular events in the short term, while those experiencing acute myocardial infarction (AMI) have a higher incidence cancer. Given limitations clinical resources, identifying shared biomarkers offers cost-effective approach to assessment by minimizing need for multiple tests and screenings. Hence, it is crucial identify common both survival AMI prediction. Our study suggests that monocyte-derived biomarkers, specifically WEE1,...
Abstract Background Bronchial asthma is one of the most common inflammatory airway disorders. As main non-drug therapies, Sanfu herbal patch (SHP) has been widely used to treat bronchial asthma, although evidence for its efficacy and associated mechanism are inconclusive. The objective this trial clarify clinical safety SHP in treatment chronic persistent or remission stage provide high-quality data further research. Methods We propose a multicentre, double-blinded, parallel, randomized,...
Abstract This study aimed to evaluate and compare the remineralisation, mechanical, anti‐aging, acid resistance antibacterial properties of calcium phosphate ion clusters (CPICs) materials with those Duraphat Icon. The remineralisation mechanical were investigated using scanning electron microscopy, Fourier‐transform infrared (FTIR) spectroscopy nanoindentation. CPICs induced epitaxial crystal growth on enamel surface, where regrown enamel‐like apatite layers had a similar hardness elastic...
Die Selbstanordnung von Nanopartikeln ist ein Schlüsselprozess bei der Bildung Einkristallen durch aggregationsinduziertes Kristallwachstum. Wie R. Tang und Mitarbeiter in ihrer Zuschrift auf S. 13028 ff. mittels hochauflösender Transmissionselektronenmikroskopie nachweisen, aggregieren zunächst Nanopartikel regellos Oberfläche eines vorliegenden Einkristalls. Anschließend drängen Oberflächenkräfte die Kristallkorngrenze vom Kristallinneren an Oberflächenschicht, um Anordnung anhaftenden zu...
Objective To develop a method for antigen dissociation and content determination of hepatitis A virus (HAV) inactivated vaccine containing aluminium adjuvant.Methods Buffer A:20％ diethanolamine 1.25 mL,10％ Triton X-100 0.2 mL,and PBS 8.55 mL; buffer B:3％(w/v) citric acid with pH=7.2; C:20％(w/v) trisodium citrate.The above 3 buffers were used to dissociate HAV adjuvant in various conditions.The those resultant samples was determined by ELISA,and then the recovery rate calculated determine...
Abstract Background Bronchial asthma (BA) is one of the most common inflammatory airway disorders. As main non-drug therapies, Sanfu herbal patch (SHP) has been widely used to treat BA, although evidence and mechanism are inconclusive. The objective this pilot trial clarify clinical efficacy safety SHP in treatment BA chronic persistent or remission stage provide high-quality data for further research.Methods: We propose a multicenter, double-blinded, parallel, randomized, placebo-controlled...