A5101808210- Bone Tissue Engineering Materials
- Membrane-based Ion Separation Techniques
- Calcium Carbonate Crystallization and Inhibition
- Fuel Cells and Related Materials
- Membrane Separation Technologies
- biodegradable polymer synthesis and properties
- nanoparticles nucleation surface interactions
- Advanced Battery Materials and Technologies
- Covalent Organic Framework Applications
- Crystallization and Solubility Studies
- Nanoplatforms for cancer theranostics
- Advanced Sensor and Energy Harvesting Materials
- Diatoms and Algae Research
- Polymer Surface Interaction Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Layered Double Hydroxides Synthesis and Applications
- Graphene and Nanomaterials Applications
- Polymer composites and self-healing
- Ionic liquids properties and applications
- Advanced Photocatalysis Techniques
- Building materials and conservation
- Extraction and Separation Processes
- Paleontology and Stratigraphy of Fossils
- Bone and Dental Protein Studies
- Bone health and osteoporosis research
Zhejiang University
2016-2025
Sir Run Run Shaw Hospital
2024
Gansu Provincial Academy of Membrane Science and Technology
2020-2024
Tongji University
2023-2024
Southwest Forestry University
2024
National Vaccine and Serum Institute
2024
State Key Laboratory of Silicon Materials
2023
State Key Laboratory of Robotics
2022
East China Normal University
2022
Shenyang Institute of Automation
2022
The regeneration of tooth enamel, the hardest biological tissue, remains a considerable challenge because its complicated and well-aligned apatite structure has not been duplicated artificially. We herein reveal that rationally designed material composed calcium phosphate ion clusters can be used to produce precursor layer induce epitaxial crystal growth enamel apatite, which mimics biomineralization crystalline-amorphous frontier hard tissue development in nature. After repair, damaged...
Insufficient intracellular anabolism is a crucial factor involved in many pathological processes the body
Abstract Spider silk fibers (SSF) have a hierarchical structure composed of proteins with highly repetitive sequences and biomineralization is sophisticated in organic–inorganic constructions. By using inorganic hydroxyapatite (HAP) organic polyvinyl alcohol (PVA) to simulate the rigid crystalline flexible amorphous protein blocks SSF, respectively, biomimetic mineralization herein attempted for large‐scale preparation SSF‐like macrofibers ordered structure, superhigh tensile strength 949 ±...
Organisms use inorganic ions and macromolecules to regulate crystallization from amorphous precursors, endowing natural biominerals with complex morphologies enhanced properties. The mechanisms by which modifiers enable these shape-preserving transformations are poorly understood. We used in situ liquid-phase transmission electron microscopy follow the evolution calcium carbonate calcite presence of additives. A combination contrast analysis infrared spectroscopy shows that Mg ions, widely...
Biomineralization brings inorganic materials into biological organisms and it plays an important role in natural evolution. Inspired by biomineralized eggs diatoms with protective shell structures, scientists have artificially endowed functional materials. The resulting organism–material hybrids become more robust even evolve new functions. This feature article reviews recent achievements of organism improvements various material shells related applications cell protection, storage, thermal...
Ionic oligomers and their crosslinking implies a possibility to produce novel organic-inorganic composites by copolymerization. Using organic acrylamide monomers inorganic calcium phosphate as precursors, uniformly structured polyacrylamide (PAM)-calcium copolymer is prepared an In contrast the previous PAM-based mixing components into polymers, copolymerized material has no interphase boundary owing homogenous incorporation of units at molecular level, resulting in complete continuous...
The making of a monolith Amorphous calcium carbonate is hard material that difficult to make into large, clear blocks. It also sensitive heating, and compacting the starting nanoparticles too much tends lead crystallization. Mu et al. determined optimal amount water in amorphous create clear, solid monoliths through compression. key regulate diffusion system so particle boundaries fuse without triggering sample-wide This fusion strategy may work for similar inorganic ionic compounds. Science...
Abstract Sensitivity and multi‐directional motivation are major two factors for developing optimized humidity‐response materials, which promising sensing, energy production, etc. Organic functional groups commonly used as the water sensitive units through hydrogen bond interactions with molecules in actuators. The multi‐coordination ability of inorganic ions implies that ionic compounds potentially superior units. However, particle forms produced by classical nucleation limit number exposed...
The development of environmentally friendly plastics is critical to ensure sustainable development. In contrast polymer derived from petrochemicals, inorganic minerals, which are the most abundant matter in Earth's crust, friendly. However, brittleness these minerals limits their applications as plastics. Here, because advantages both biomineralization and ionic polymerization, calcium phosphate (CaP, a typical geological biological mineral) oligomers used for biomimetic mineralization under...
The nacre-inspired laminates are promising materials for their excellent mechanics. However, the interfacial defects between organic–inorganic phases commonly lead to crack propagation and fracture failure of these under stress. A natural biomineral, bone, has much higher bending toughness than nacre. small size inorganic building units in bone improves interaction, which optimizes material toughness. Inspired by biological structures, here, an ultratough nanocomposite laminate is prepared...
A critical-sized bone defect, which cannot be repaired through self-healing, is a major challenge in clinical therapeutics. The combination of biomimetic hydrogels and nano-hydroxyapatite (nano-HAP) promising way to solve this problem by constructing an osteogenic microenvironment. However, it challenging generate nano-HAP with similar morphology structure that natural bone, limits the improvement regeneration hydrogels. Inspired our previous works on organic-inorganic cocross-linking, here,...
Abstract Mechanical robust hydrogels are ideal for applications in energy, environment, biomedicine, and structural engineering materials fields. However, high strength toughness usually conflict with each other, simultaneously achieving both of them within a hydrogel has been challenging. Herein an organic‐inorganic synergistic toughening strategy is reported via in‐situ inorganic ionic polymerization calcium phosphate oligomers polymer composite networks composed polyvinyl alcohol chains...
By rationally selecting ionic oligomers as building blocks, sub-nano-sized gaps can be constructed in the solid structure of catalysts. This overcome inherent limitations associated with vacancy formation traditional nucleation pathway.
The application of nanotechnology for in medicine is developing rapidly, thereby increasing human exposure to nanomaterials and significantly so. A rising question the biosecurity nanoparticles (NPs). Although calcium phosphate (CaP) phase biocompatible biodegradable, many vitro experiments have demonstrated that its NPs significant cytotoxicity. This toxicity due released Ca2+ ions from internalized CaP within cells initiate apoptosis. Different such an understanding, we reveal actually...
During nanoparticle coalescence in aqueous solution, dehydration and initial contact of particles are critically important but poorly understood processes. In this work, we used situ liquid-cell transmission electron microscopy to directly visualize the process Au nanocrystals. It is found that atomic nanobridge forms between adjacent nanocrystals separated by a ∼0.5 nm hydration layer. The structure first induces over their layers then surface diffusion grain boundary migration rearrange...