A5080681893- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Inflammatory mediators and NSAID effects
- Genetic factors in colorectal cancer
- Galectins and Cancer Biology
- Veterinary medicine and infectious diseases
- Eosinophilic Esophagitis
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Garlic and Onion Studies
- Mycobacterium research and diagnosis
- Gut microbiota and health
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Gastroesophageal reflux and treatments
- Glutathione Transferases and Polymorphisms
- Gastrointestinal disorders and treatments
- Estrogen and related hormone effects
- Cytokine Signaling Pathways and Interactions
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
Peking University
2016-2025
Peking University Cancer Hospital
2016-2025
Zhejiang University
2023-2024
Sir Run Run Shaw Hospital
2023-2024
Technical University of Munich
2021-2024
Ministry of Education
2009-2023
Blood Center of Zhejiang Province
2023
ShenZhen People’s Hospital
2020
Harbor–UCLA Medical Center
2019
House Clinic
2019
In the Shandong Intervention Trial, 2 weeks of antibiotic treatment for Helicobacter pylori reduced prevalence precancerous gastric lesions, whereas 7.3 years oral supplementation with garlic extract and oil (garlic treatment) or vitamin C, E, selenium (vitamin did not. Here we report 14.7-year follow-up cancer incidence cause-specific mortality among 3365 randomly assigned subjects in this masked factorial placebo-controlled trial. Conditional logistic regression was used to estimate odds...
Background: Randomized trials have yielded mixed results on the effects of treatment for Helicobacter pylori and little information vitamins or garlic supplements precancerous gastric lesions. We conducted a randomized trial to test one-time H. long-term vitamin in reducing prevalence advanced Methods: Most adults aged 35–64 years 13 randomly selected villages Linqu County, Shandong Province, China, were identified given baseline endoscopies 1994. In 1995, 3365 eligible subjects assigned...
Gastrointestinal microbiota may be involved in Helicobacter pylori-associated gastric cancer development. The aim of this study was to explore the possible microbial mechanisms carcinogenesis and potential dysbiosis arising from H. pylori infection.Deep sequencing 16S ribosomal RNA gene used investigate alterations paired biopsies stool samples 58 subjects with successful 57 failed anti-H. treatment, relative 49 negative subjects.In positive subjects, richness Shannon indexes increased...
To assess the effects of Helicobacter pylori treatment, vitamin supplementation, and garlic supplementation in prevention gastric cancer.Blinded randomized placebo controlled trial.Linqu County, Shandong province, China.3365 residents a high risk region for cancer. 2258 participants seropositive antibodies to H were randomly assigned or their placebos 2×2×2 factorial design, 1107 seronegative 2×2 design.H treatment with amoxicillin omeprazole two weeks; (C, E, selenium) (extract oil) 7.3...
Helicobacter pylori infection and the cytokine-mediated inflammatory responses play important roles in gastric cancer pathogenesis. This case control study was conducted to assess association between genetic polymorphisms interleukin (IL)-1B, IL-1RN, IL-8, IL-10 tumor necrosis factor alpha (TNFalpha), which are involved H.pylori infection, risk of cancer. Genotypes were determined by PCR-based denaturing high-performance liquid chromatography analysis direct DNA sequencing 250 incident cases...
Background To investigate the potential of serum miRNAs as biomarkers for early detection gastric cancer (GC), a population-based study was conducted in Linqu, high-risk area GC China. Methodology/Principal Findings All subjects were selected from two large cohort studies. Differential identified pools and control using TaqMan low density array, validated individual 82 pairs control, 46 dysplasia by real-time quantitative reverse transcription-polymerase chain reaction. The temporal trends...
<h3>Objective</h3> To clarify the full range of benefits and adverse consequences <i>Helicobacter pylori</i> eradication as a strategy for gastric cancer prevention, community-based intervention trial was launched in Linqu County, China. <h3>Design</h3> A total 184 786 residents aged 25–54 years were enrolled this received <sup>13</sup>C-urea breath test. <i>H. positive participants assigned into two groups, either receiving 10-day quadruple anti-<i>H. treatment or lookalike placebos...
Among 2258 Helicobacter pylori-seropositive subjects randomly assigned to receive one-time H. pylori treatment with amoxicillin-omeprazole or its placebo, we evaluated the 15-year effect of on gastric cancer incidence and mortality in subgroups defined by age, baseline histopathology, post-treatment infection status. We used conditional logistic Cox regressions for covariable adjustments analyses, respectively. Treatment was associated a statistically significant decrease (odds ratio = 0.36;...
<h3>Objective</h3> <i>Helicobacter pylori</i> infection and overexpression of cyclo-oxygenase-2 (COX-2) are associated with gastric cancer its precursors. To evaluate the effect a selective COX-2 inhibitor alone combined <i>H eradication on evolution precancerous lesions, randomised, placebo-controlled trial was conducted in Linqu County, Shandong Province, China. <h3>Methods</h3> A total 1024 participants aged 35–64 years advanced lesions were randomly assigned factorial design to two...
Eradication of Helicobacter pylori has been found to be effective for gastric cancer prevention, but uncertainties remain about the possible adverse consequences such as potential microbial dysbiosis. In our study, we investigated association between gut microbiota and H. pylori-related lesions in 47 subjects by deep sequencing 16S ribosomal RNA (rRNA) gene fecal samples. The dominant phyla samples were Bacteroidetes, Firmicutes Proteobacteria with average relative abundances 54.77%, 31.37%...
Gastric cancer (GC) is one of the major cancers in China and all over world. Most GCs are diagnosed at an advanced stage with unfavorable prognosis. Along some other countries, has developed government-funded national screening programs for GC cancers. been shown to effectively decrease incidence mortality from countries adopting nationwide (Japan Korea) studies based on selected Chinese populations. The relies mostly gastroendoscopy, accuracy, reliability safety which have indicated by...
<h3>Importance</h3> Metabolic deregulation plays an important role in gastric cancer (GC) development. To date, no studies have comprehensively explored the metabolomic profiles along cascade of lesions toward GC. <h3>Objective</h3> draw a metabolic landscape and define signatures associated with progression risk early <h3>Design, Setting, Participants</h3> A 2-stage, population-based cohort study was initiated 2017 Linqu County, Shandong Province, China, high-risk area for Prospective...
ABSTRACT Background. Helicobacter pylori infection is a major cause of peptic ulcer disease and gastric cancer. This study postulated that cranberry juice would be effective in the suppression H. an endemically infected population at high risk for Materials methods. A prospective, randomized, double‐blind, placebo‐controlled trial was conducted Linqu County Shandong Province, China, where 189 adults aged 48.9 ± 11.2 years (mean SD) with were randomly divided into two groups: (n = 97) placebo...
Helicobacter pylori infection induces a number of pro-inflammatory signaling pathways contributing to gastric inflammation and carcinogenesis has been identified as major risk factor for the development cancer (GC). Janus kinase-signal transducer activator transcription (JAK-STAT) mediates immune regulatory processes, including tumor-driven escape. Programmed death ligand 1 (PD-L1) expressed on epithelium can suppress system by shutting down T cell effector function. In human cohort subjects...
Abstract Background: Genetic polymorphisms of Toll-like receptors (TLR) may influence the outcome Helicobacter pylori infection and play important roles in gastric carcinogenesis. To screen genetic variants TLR2 TLR5, evaluate their associations with cancer (GC) its precursors, a population-based study was conducted Linqu County, Shandong Province, China. Methods: were identified by PCR-based denaturing high-performance liquid chromatography PCR-restriction fragment length polymorphism...
Molecular features underlining the multistage progression of gastric lesions and development early cancer (GC) are poorly understood, restricting ability to GC prevention management.We portrayed proteomic landscape explored signatures associated with risk GC. Tissue profiling was conducted for a total 324 subjects. A case-control study performed in discovery stage (n=169) based on populations from Linqu, known high-risk area China. We then two-stage validation, including cohort Linqu (n =...
Rationale: Gastric cancer (GC) is preceded by a stepwise progression of precancerous gastric lesions. Distinguishing individuals with lesions that have potential to GC an important need. Perturbated lipid metabolism, particularly the dysregulation de novo lipogenesis, involved in carcinogenesis. We conducted first prospective lipidomics study exploring lipidomic signatures for risk lesion and early GC. Methods: Our two-stage targeted enrolled 400 subjects from National Upper Gastrointestinal...
Gastric microbiota and metabolites may interact play collaborative roles in the carcinogenesis process. This study aims to investigate differential microbes, as well possible of microbe-metabolite interactions gastric cancer (GC) development. Targeted metabolomics assays 16S rRNA sequencing were performed compare metabolic microbial profiles tissues from subjects with superficial gastritis/chronic atrophic gastritis (SG/CAG), intestinal metaplasia/low-grade intraepithelial neoplasia...