A5017093564- Occupational and environmental lung diseases
- Chromium effects and bioremediation
- Carcinogens and Genotoxicity Assessment
- Head and Neck Cancer Studies
- Toxic Organic Pollutants Impact
- Heavy Metal Exposure and Toxicity
- Air Quality and Health Impacts
- MicroRNA in disease regulation
- Effects and risks of endocrine disrupting chemicals
- Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Ear and Head Tumors
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Plant and animal studies
- Biomarkers in Disease Mechanisms
- Trace Elements in Health
- Cancer Research and Treatments
- Evaluation Methods in Various Fields
- Tissue Engineering and Regenerative Medicine
Hangzhou Medical College
2020-2025
Huzhou University
2022-2025
Zhejiang Cancer Hospital
2013-2024
Chinese Academy of Sciences
2020-2024
Zhejiang Academy of Medical Sciences
2013-2023
University of Chinese Academy of Sciences
2020-2022
Cancer Hospital of Chinese Academy of Medical Sciences
2020-2022
University of Benin
2020
GTx (United States)
2020
Harvard University
2016
Malignant parotid tumors are rare metastases originating from nasopharyngeal carcinoma (NPC). This study aimed to investigate the clinicopathological features and outcome of patients with metastasis NPC lymph nodes after surgical therapy. We enrolled 14 who had metastatic disease IMRT. They received treatment by total parotidectomy neck dissection, superficial partial parotidectomy, or parotidectomy. Their age, gender, histopathology, clinical findings, were analyzed. After radiotherapy,...
Significance To address a crucial knowledge deficiency concerning the correlation between nanoparticles (NPs) exposure and cardiovascular diseases, here we present toxicological mechanism for inhaled NPs by delineating their interactions with biomacromolecules encountered en route. In biological ambience, are known to spontaneously adsorb proteins, thereby acquiring new identity further entailing pathological prospects. Here, found that silica (SiNPs) specifically adsorbed apolipoprotein A-I...
Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon malignant tumor with highly aggressive biological behavior. Our goal was to investigate the prognosis of CXPA in major salivary glands and factors influencing it.We retrospectively reviewed 51 patients diagnosed between 1999 2006, comprising 36 males 15 females, aged from 23 86 years. All underwent surgery curative intention, 21 received postoperative radiation therapy.Of patients, 39.2% developed locoregional recurrence 27.5% distant...
IntroductionIn the Western world, malignant mesothelioma (MM) is most prevalent in pleura of older males who have been professionally exposed to asbestos. Information about MM from rapidly industrializing countries such as China minimal. There concern that a proportion diagnoses may be incorrect because Chinese physicians do not experience diagnosing this rare cancer. We recently reported an unusually high incidence peritoneal among eastern female patients. Here, we review accuracy and...
The presence of perfluoroalkyl acids (PFAAs) and chlorinated polyfluoroalkyl ether sulfonates (Cl-PFAESs) in humans has attracted great attention recent decades. However, information on their exposure sources the influence age gender Cl-PFAES concentrations human serum is still limited. In this study, eighty-five samples were collected from general population Anji, China, analyzed for carboxylates (PFCAs), (PFSAs), Cl-PFAESs. Perfluorooctane sulfonate (PFOS; mean, 5.9 ng/mL)...
Hexavalent Chromium [Cr (VI)] is an established toxicant, carcinogen, and a significant source of public health concern. The multicopy ribosomal DNA (rDNA) array mechanistically linked to aging cancer, the most evolutionarily conserved segment human genome, gives origin nucleolus, nuclear organelle where ribosomes are assembled. Here we show that exposure Cr (VI) induces instability in rDNA, triggering cycles rapid, specific, transient amplification contraction cells. dynamic environmentally...
Hexavalent chromium [Cr(IV)], a well-known industrial waste product and an environmental pollutant, is recognized as human carcinogen. But its mechanisms of carcinogenicity remain unclear, recent studies suggest that DNA methylation may play important role in the carcinogenesis Cr(IV). The aim our study was to investigate effects Cr(IV) on cell cycle progress, global methylation, p16 gene. A B lymphoblastoid line lung A549 were exposed 5–15 µM potassium dichromate or 1.25–5 µg/cm2 lead...
High-mobility group box 1 (HMGB1) functions as a proinflammatory cytokine and is one of the most intriguing molecules in inflammatory disorders cancers. Notably, HMGB1 potential therapeutic target novel biomarker related diseases. However, diagnostic value for benign malignant asbestos-related diseases (ARDs) remains unclear. In this work, we detected preoperative serum levels Chinese asbestos-exposed (AE) ARDs populations further evaluated patients with certain types ARDs, including those...
Benzene is metabolized to hydroquinone in liver and subsequently transported bone marrow for further oxidization 1,4-benzoquinone (1,4-BQ), which may be related the leukemia other blood disorders. In present study, we investigated proteome profiles of human primary mesenchymal stem cells (hBM-MSCs) treated by 1,4-BQ. We identified 32 proteins that were differentially expressed. Two them, HSP27 Vimentin, verified at both mRNA protein levels their cellular localization was examined...
Abstract Background Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and lethal malignancies. Long non-coding RNAs (lncRNAs) are being found to play crucial roles in ATC progression. Herein, we focused on role nuclear paraspeckle assembly transcript 1 (NEAT1) progression under hypoxia underlying mechanisms governing it. Methods The expression levels NEAT1, miR-206 miR-599 were assessed by quantitative real-time polymerase chain reaction (qRT-PCR). Cell migration invasion...
The ribosomal DNA (rDNA) can act as a sensor and responder of cancer-associated stress. Here we investigated rDNA copy number in gastric cancers its association with existing biomarkers metals exposure. This study was performed on paired tumor adjacent normal tissues obtained from 65 cancer patients who underwent gastrectomy. Immunohistochemistry used to assess HER-2, E-cadherin, EGFR, CK (pan), CK20, CK7, TopoⅡ, CAM5.2, P53, Ki-67 expression. Inductively coupled plasma mass spectrometry...