A5007218112- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Renal cell carcinoma treatment
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Renal and related cancers
- Hepatocellular Carcinoma Treatment and Prognosis
- TGF-β signaling in diseases
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Bladder and Urothelial Cancer Treatments
- Occupational and environmental lung diseases
- Tumors and Oncological Cases
- Soft tissue tumor case studies
- Urologic and reproductive health conditions
- Cardiac tumors and thrombi
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Soft tissue tumors and treatment
- Oral and Maxillofacial Pathology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Microtubule and mitosis dynamics
Zhejiang Provincial People's Hospital
2016-2025
Hangzhou Medical College
2017-2023
Second Affiliated Hospital of Xi'an Jiaotong University
2022
First Affiliated Hospital Zhejiang University
2016
Ningbo University
2009
Liaoning University of Technology
2009
In this paper, an adaptive fuzzy output feedback control approach is proposed for single-input-single-output nonlinear systems without the measurements of states. The addressed in paper are assumed to possess unmodeled dynamics presence unstructured uncertainties and dynamic disturbances, where not linearly parameterized, no prior knowledge their bounds available. Fuzzy logic used approximate uncertainties, a state observer developed estimate unmeasured By combining backstepping technique...
Roles of liver-specific genes (LSGs) in tumor initiation and progression are rarely explored hepatocellular carcinoma (HCC). Here we show that LSGs generally downregulated HCC tissues compared to non-HCC liver tissues, low-LSG HCCs poor prognosis the activated c-Myc pathway. Among c-Myc- patient prognosis-associated LSGs, PGRMC1 significantly blocks c-Myc-induced orthotopic formation. The role depends on its localization endoplasmic reticulum (ER) membrane, where interacts with PERK through...
Abstract RNF214 is an understudied ubiquitin ligase with little knowledge of its biological functions or protein substrates. Here we show that the TEAD transcription factors in Hippo pathway are substrates RNF214. induces non-proteolytic ubiquitylation at a conserved lysine residue TEADs, enhances interactions between TEADs and YAP, promotes transactivation downstream genes signaling. Moreover, YAP TAZ could bind polyubiquitin chains, implying underlying mechanisms by which regulates...
High expression of substance P and its receptor neurokinin-1 in colorectal cancer is associated with tumor progression prognosis Xiao-Yi Chen,1,* Guo-Qing Ru,2,* Ying-Yu Ma,1 Jun Xie,3 Wan-Yuan Chen,2 Hui-Ju Wang,1 Shi-Bing Li Li,1 Ke-Tao Jin,4 Xiang-Lei He,2 Xiao-Zhou Mou1 1Clinical Research Institute, 2Department Pathology, Zhejiang Provincial People’s Hospital, Hangzhou, 3Department Anus-Intestines, Affiliated Hospital Shaoxing University, 4Department Gastrointestinal Surgery,...
High-mobility group box 1 (HMGB1) functions as a proinflammatory cytokine and is one of the most intriguing molecules in inflammatory disorders cancers. Notably, HMGB1 potential therapeutic target novel biomarker related diseases. However, diagnostic value for benign malignant asbestos-related diseases (ARDs) remains unclear. In this work, we detected preoperative serum levels Chinese asbestos-exposed (AE) ARDs populations further evaluated patients with certain types ARDs, including those...
Chronic infection of Mycoplasma hyorhinis (M. hyorhinis) has been postulated to be associated with several types cancer, but its effect on patients' survival and host factors mediating remain unclear. Herein, we demonstrated that M. p37 protein expression in gastric cancer tissues predicts poor associates metastasis. infects mammalian cells promotes cell invasiveness via membrane p37. Synthesized peptide corresponding the N-terminus prevents infection. Host Annexin A2 (ANXA2) interacts In...
While chrysotile has been commonly used by Chinese textile industry for many years, investigations on the association of exposure with risk mesothelioma in China are scarce. We conducted a case–control study county located at Southeastern China, including 46 cases and 230 individually matched controls. A semi‐quantitative method based experts' assessment was evaluating hand‐spinning exposure. Conditional logistic regression models were to assess asbestos mesothelioma. found that associated...
The role of forkhead box O3 (FOXO3) as a tumor suppressor gene and its association with the human lifespan is well documented. However, several studies have indicated that high expression FOXO3 also significantly associated tumorigenesis. aim present study was to determine clinical significance in development prognosis hepatocellular carcinoma (HCC). mRNA data from Cancer Genome Atlas database analyzed through UALCAN online tool compare between HCC normal liver tissues. Subsequently, at...
// Guo-Qing Ru 1, * , Yong Han 2, Wei Wang 1 Yuan Chen Hui-Ju 2 Wen-Juan Xu Jie Ma Meihua Ye Xi 3 Xiang-Lei He Balázs Győrffy 4, 5 Zhong-Sheng Zhao and Dongsheng Huang Department of Pathology, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang, PR China Clinical Research Institute, VIP Medical Center, 4 Momentum Cancer Biomarker Group, Centre for Natural Sciences, Hungarian Academy Budapest, Hungary Second Pediatrics, Semmelweis University, These auuthors have contributed...
Abstract Background Dermatofibrosarcoma protuberans (DFSP) is a superficial fibroblastic tumor characterized by high rate of local recurrence and low metastatic potential. Fibrosarcomatous transformation can rarely arise in DFSP either de novo or as recurrent, which represents form progression carries an increased risk metastasis over classic DFSP. Cytogenetically, recurrent unbalanced chromosome translocation t (17;22)(q22;q13), leading to the formation COL1A1-PDGFB fusion transcript that...
Fibrinogen-like-protein 1 (FGL1), a member of the fibrinogen-related protein (FREP) family, is major ligand immune inhibitory receptor lymphocyte-activation gene 3 (LAG-3). While FGL1 strongly implicated in development and prognosis variety diseases, its role hepatocellular carcinoma (HCC) still disputed. Therefore, expression progression HCC was investigated.In present study, bioinformatics analysis first used to probe profile multiple malignant tumor tissues paired normal tissues, explore...
Intrahepatic cholangiocarcinoma (iCCA) is a highly lethal biliary epithelial cancer in the liver. Here, Laminin subunit gamma-2 (LAMC2) with important oncogenic roles iCCA discovered. In total of 231 patients (82% patients) across four independent cohorts, LAMC2 significantly more abundant tumor tissue compared to normal bile duct and non-tumor Among 26.3% patients, gene amplified, contributing its over-expression. Functionally, silencing blocks formation orthotopic mouse models....
Alveolar soft part sarcoma (ASPS) is a rare, malignant mesenchymal tumor of distinctive clinical, morphologic, ultrastructural, and cytogenetical characteristics. It typically arises in the extremities adolescents young adults, but has also been documented number unusual sites, thus causing diagnostic confusions both clinically morphologically. The molecular signature ASPS specific der(17)t(X;17)(p11.2;q25) translocation, which results fusion TFE3 transcription factor gene at Xp11.2 with...
Fibulin-3 has been reported as a potential biomarker for mesothelioma. However, little is known about the diagnostic efficacies of fibulin-3 asbestos-related diseases (ARDs) in China. This study was to investigate utility asbestos exposure and ARDs. A total 430 subjects were recruited from Southeast China, including healthy individuals, asbestos-exposed (AE) patients with pleural plaques (PP), asbestosis, malignant mesothelioma (MPM). Plasma measured using enzyme-linked immunosorbent assay....
The coxsackie and adenovirus receptor (CAR) is considered a tumor suppressor critical factor for the efficacy of therapeutic strategies that employ adenovirus. However, data on CAR expression levels in colorectal cancer are conflicting its clinical relevance remains to be elucidated. Immunohistochemistry was performed tissue microarrays containing 251 pairs colon adjacent normal samples from Chinese Han patients assess CAR. Compared with healthy mucosa, decreased (40.6% vs. 95.6%; P<0.001)...
Gene therapy using oncolytic adenoviruses is a novel approach for human cancer therapeutics. The current study aimed to investigate whether the combined use of an adenovirus expressing tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) and second mitochondria‑derived activator caspase (Smac) upon activation (ZD55‑TRAIL‑IETD‑Smac) cyclin‑dependent kinase (CDK) inhibitor SNS‑032 will synergistically reinforce their anti‑pancreatic activities. experiments in vitro demonstrated that...
BACKGROUND: NIMA-related kinase 2 (NEK2), a serine/threonine kinase, is located in the centrosome and member of cell cycle regulation related protein (CCRK) family. Aberrant expression NEK2 linked with carcinogenesis progression various tumors. OBJECTIVE: To investigate level its relationship clinicopathological factors hepatocellular carcinoma (HCC). METHODS: Immunohistochemistry was used to measure 310 patients' specimen tissues 197 adjacent normal liver HCC cases, subsequent prognostic...
Corticotropin releasing hormone binding protein (CRHBP) mediates the reaction between corticotropin (CRH) and receptors (CRHRs). It is expressed in a number of organs, expression CRHBP associated with tumorigenesis cancer progression. The aim present study was to investigate levels hepatocellular carcinoma (HCC) its association patient clinicopathological characteristics as well prognosis. examined by immunohistochemistry 169 HCC tissues 151 adjacent non-tumorous tissues. results were...