A5003702822- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Occupational and environmental lung diseases
- COVID-19 epidemiological studies
- Tissue Engineering and Regenerative Medicine
- COVID-19 Pandemic Impacts
- SARS-CoV-2 and COVID-19 Research
- MicroRNA in disease regulation
- High Altitude and Hypoxia
- Viral Infections and Outbreaks Research
- Neurogenetic and Muscular Disorders Research
- Cardiovascular Health and Risk Factors
- Adipose Tissue and Metabolism
- Amyotrophic Lateral Sclerosis Research
- Nutrition, Genetics, and Disease
- Metabolomics and Mass Spectrometry Studies
- Genetics and Neurodevelopmental Disorders
- Advanced Glycation End Products research
- Heme Oxygenase-1 and Carbon Monoxide
- Spaceflight effects on biology
- COVID-19 and Mental Health
- Biomarkers in Disease Mechanisms
- Traditional Chinese Medicine Studies
- Health Promotion and Cardiovascular Prevention
- Neuroscience of respiration and sleep
Fudan University
2020-2023
State Key Laboratory of Genetic Engineering
2021-2023
Shanghai Municipal Center For Disease Control Prevention
2019
Zhejiang Academy of Medical Sciences
2017
High-mobility group box 1 (HMGB1) functions as a proinflammatory cytokine and is one of the most intriguing molecules in inflammatory disorders cancers. Notably, HMGB1 potential therapeutic target novel biomarker related diseases. However, diagnostic value for benign malignant asbestos-related diseases (ARDs) remains unclear. In this work, we detected preoperative serum levels Chinese asbestos-exposed (AE) ARDs populations further evaluated patients with certain types ARDs, including those...
Summary Background In December 2019, pneumonia infected with a novel coronavirus burst in Wuhan, China. Now the situation is almost controlled China but worse outside We aimed to build mathematical model capture global trend of epidemics Methods this retrospective, outside-China diagnosis number reported from Jan 21 Feb 28, 2020 was downloaded WHO website. develop simple regression on these numbers: where N t total diagnosed patient till i th day, t=1 at 1. Findings Based model, we estimate...
COVID-19 raised tension both within China and internationally. Here, we used mathematical modeling to predict the trend of patient diagnosis outside in future, with aim easing anxiety regarding emergent situation. According all number from WHO website combining transmission mode infectious diseases, model was fitted future outbreak. Daily numbers countries were downloaded situation reports. The data for this analysis collected January 21, 2020 currently end at February 28, 2020. A simple...
Altitude acclimatization is a human physiological process of adjusting to the decreased oxygen availability. Since several processes are involved and their correlations complicated, analyses single traits insufficient in revealing complex mechanism high-altitude acclimatization. In this study, we examined these responses as composite phenotypes that represented by linear combination traits. We developed strategy combines both spectral clustering partial least squares path modeling (PLSPM)...
Despite being a commercially important product, multiwalled carbon nanotubes (MWCNTs) continue to raise concerns over human health due their structural similarity asbestos. Indeed, exposure MWCNT has been shown induce lung cancer and even mesothelioma, but contradictory results also exist. To clarify the potentially carcinogenic effects of rigid rod-like elucidate underlying mechanisms, on mesothelial cell MeT-5A were examined throughout 3 months continuous exposure, including cytotoxicity,...
To explore the familial aggregation and heritability of hypertension in Han Shanghai China.According to l:l matched pairs design, 342 patients controls were selected investigate their nuclear family members case-control study. The method genetic epidemiology research was used hypertension.The prevalence rate first-degree relatives significantly higher (34.44%) than that second- degree (17.60%) third-degree (13.51%) Population China. Separation ratio p 0.217, case group control relatives....
Purpose: This study aimed to quantify the different quadrants of optic nerve head (ONH) and macular parameters their changes during exposure high altitude, assess correlation with high-altitude headache (HAH). Methods: Spectral-domain optical coherence tomography (OCT) was used in retinal structure 109 healthy subjects acute altitude (3,700 m). Self-reported symptoms HAH mountain sickness AMS were assessed using Lake Louise Score (LLS), alongside measurements physiological (oxygen saturation...
Abstract Importance To predict the diagnosed COVID-19 patients and trend of epidemic in China. It may give public some scientific information to ease fear epidemic. Objective In December 2019, pneumonia infected with novel coronavirus burst Wuhan, We aimed use a mathematical model number future anxiety on emergent situation. Design According all diagnosis from WHO website combining transmission mode infectious diseases, was fitted outbreak. Setting Our based situation China, which could...
Pleural malignant mesothelioma (MM) is a highly aggressive tumor that typically related to asbestos exposure and has latency of 20-60 years. Several microRNA contribute MM initiation progression, but the mechanisms are not clear. Here, we found miR-30d downregulated in pleural cell line NCI-H2452, plasma asbestos-exposed individuals, mesothelial cells. Furthermore, investigated influence overexpression We demonstrated could suppress proliferation, migration, invasion vitro promote apoptosis...
Aim: We aimed to explore miRNA expression profiles in hand-spinning chrysotile exposed workers and their potential influencing factors. Methods: array technique was applied screen differentially expressed miRNAs between plasma samples from three controls. Then, seven selected were validated 143 100 controls, the factors revealed by multiple linear regression. Finally, levels of those evaluated human mesothelial cells (Met-5A) that at 5 μg·cm-2 for 8, 24 48 h, respectively. Results &...
Abstract Chrysotile, which is classified as a class I carcinogen by the International Agency for Research on Cancer (IARC), has extensive application in industry and can lead to lung or other cancers. However, whether chrysotile causes malignant mesothelioma its molecular mechanism remain debatable. Thus, this study aimed demonstrate mesothelioma‐inducing potential of at mesothelial cellular level function microRNA‐28 malignantly transformed MeT‐5A cells. cells nontoxic dose were named...
Abstract In December 2019, pneumonia infected with the novel coronavirus burst in Wuhan, China. We aimed to use a mathematical model predict number of diagnosed patients future ease anxiety on emergent situation. Our was based epidemic situation China, which could provide referential significance for disease prediction other countries, and clues prevention intervention relevant health authorities. this retrospective, all diagnosis from Jan 21 Feb 10, 2020 reported China included downloaded...
Abstract Background Multi-walled carbon nanotube (MWCNT) is one of the most widely used manufactured nanomaterials, however, its potential harmful effect on human health great concern. Previously we have shown acute and chronic exposure to MWCNT induced different responses in mesothelial MeT-5A cells. In current study, cells were continuously subjected at 10 μg/cm 2 for 48 h per passage, up a whole year, further clarify carcinogesis mechanisms MWCNT. Results After one-year treatment,...