A5101754812- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Viral Infections and Outbreaks Research
- Agronomic Practices and Intercropping Systems
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Neurological diseases and metabolism
- Machine Learning and Data Classification
- Viral gastroenteritis research and epidemiology
- RNA regulation and disease
- Bryophyte Studies and Records
- Cancer-related gene regulation
- Animal Virus Infections Studies
- Bayesian Modeling and Causal Inference
- Distributed Control Multi-Agent Systems
- Piperaceae Chemical and Biological Studies
- Hepatitis B Virus Studies
- Hereditary Neurological Disorders
- Autoimmune Neurological Disorders and Treatments
- RNA Research and Splicing
- Veterinary medicine and infectious diseases
- Chromatography in Natural Products
- Environmental Changes in China
- Marine and coastal ecosystems
- Explainable Artificial Intelligence (XAI)
Huashan Hospital
2019-2025
Fudan University
2019-2025
Jiangxi Agricultural University
2024-2025
Hangzhou Dianzi University
2024
Northeast Forestry University
2024
Yanshan University
2023-2024
Jilin Agricultural University
2023-2024
Chinese Academy of Sciences
2021-2024
University of Chinese Academy of Sciences
2021-2024
Wuhan Institute of Virology
2021-2024
Background/Aims: Obesity-associated fatty liver disease affects millions of individuals. This study aimed to evaluate the therapeutic effects baicalin treat obesity and in high fat diet-induced obese mice, potential molecular mechanisms. Methods: High animals were treated with different doses (100, 200 400 mg/kg/d). Whole body, pad weighed. Hyperlipidemia, steatosis, function, hepatic Ca2+/CaM-dependent protein kinase β (CaMKKβ) / AMP-activated (AMPK) acetyl-CoA carboxylase (ACC) further...
<h3>Background and Objectives</h3> To characterize the clinical neuroimaging phenotypes of patients with autoantibodies to γ-aminobutyric acid type A receptor (GABA<sub>A</sub>R). <h3>Methods</h3> Ten against GABA<sub>A</sub>R from Huashan Hospital Autoimmune Encephalitis cohort were identified. We used MRI assessments examinations summarize major profile visualize quantify lesion distribution features. The relationship between features, phenotypes, topology expression further investigated....
Abstract African swine fever is a fatal infectious disease caused by virus (ASFV). The high mortality this significant challenge to the industry worldwide. ASFV virulence related its ability antagonize IFN response, yet mechanism of antagonism not understood. Recently, less virulent recombinant has emerged that EP402R gene deletion within parental HLJ/18 (ASFV-ΔEP402R) strain. encodes CD2v. Hence we hypothesized uses CD2v protein evade type I IFN–mediated innate immune response. We found...
ABSTRACT Background The diagnostic and prognostic values of serum neurofilament light chain (sNfL), in comparison to cerebrospinal fluid (CSF) (cNfL), other clinical parameters amyotrophic lateral sclerosis (ALS) at the time diagnosis remain elusive. Methods We examine paired CSF samples from 80 ALS patients 21 control subjects, all obtained diagnosis. Additional were collected 51 patients. NfL concentrations quantified using single molecule array (Simoa) technique. Results Our findings...
Neurofilaments in cerebrospinal fluid (CSF) and blood are considered promising biomarkers of amyotrophic lateral sclerosis (ALS) because their levels can be significantly increased patients with ALS. However, the roles neurofilaments, especially prognosis ALS inconsistent. We performed a meta-analysis to explore prognostic neurofilaments patients.
Glioblastoma (GBM) is the most common and aggressive brain tumor in adults, which chemokines are often upregulated may play pivotal roles their development progression. Chemokines a large subfamily of cytokines with leukocyte chemotactic activities involved various However, gene expression patterns on global scale were not known GBM.Differentially expressed chemokine genes glioma normal samples screened by using The Cancer Genome Atlas (TCGA) database. Cox regression identified...
An escalating pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has severely impacted global health. There is a lack of specific treatment options for diseases SARS-CoV-2. In this study, we used pseudotype virus (pv) containing SARS-CoV-2 S glycoprotein to screen botanical drug library 1037 drugs identify agents that prevent entry into cell. Our study identified four hits, including angeloylgomisin O, schisandrin B, procyanidin, and oleanonic acid, as...
BackgroundNasopharyngeal carcinoma (NPC) exhibits significant familial aggregation; however, its susceptibility genes are largely unknown. Thus, this study aimed to identify germline mutations that might contribute the risk of NPC, and explore their biological functions.MethodsWhole-exome sequencing was performed in 13 NPC pedigrees with multiple cases. Mutations co-segregated disease status were further validated a cohort composed 563 probands from independent families, 2,953 sporadic...
Lassa virus (LASV) is an enveloped, negative-sense RNA that causes hemorrhagic fever. Successful entry of LASV requires the viral glycoprotein 1 (GP1) to undergo a receptor switch from its primary alpha-dystroglycan (α-DG) endosomal lysosome-associated membrane protein (LAMP1). A conserved histidine triad in GP1 has been reported be responsible for switch. To test hypothesis other non-conserved residues also contribute switch, we constructed series mutant proteins and tested them binding...
The difference between traditional IT network and industrial control determines the different methods of security assessment. In face increasingly serious cybersecurity status, assessment research faces new challenges. This paper compares composition, function possible damage network, discusses existing standards key technologies related to It analyzes challenges faced by two networks looks forward future research.
Spinal muscular atrophy with lower extremity predominance 1 (SMALED1) and Charcot-Marie-Tooth diseasetype 2O (CMT2O) are two kinds of hereditary neuromuscular diseases caused by DYNC1H1 mutations. In this study, we reported patients SMALED1 The genotype-phenotype correlations were further analyzed systematically reviewing previous relevant publications.Two patients' their parents' clinical data collected, detailed examinations performed. WES was then applied, which confirmed Sanger...
Capecitabine is an extensively used oral prodrug of 5-fluorouracil in treatment colon cancer and known to cause hand-foot syndrome (HFS). As the target enzyme for capecitabine, thymidylate synthase (TYMS) plays a key role metabolism has been associated with some side effects caused by capecitabine. The aim our study identify possible genetic predictors capecitabine-induced HFS (CAP-HFS) Chinese colorectal patients.Whole exons TYMS were sequenced 288 extreme phenotype patients, including 144...
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disease with no curative treatment up to now. This study aims analyze ALS progression of patients treated mouse nerve growth factor (mNGF), as well the effects, side and adverse events therapy.A retrospective, observational was performed including 94 from July 2020 2021. Thirty-two them were at least one course mNGF on regular riluzole use, rest 62 only. The declining rates body mass index (BMI) Functional Rating Scale-Revised...
To investigate surgical management of type III EACC with lesions involving the posterior external auditory canal and mastoid.This retrospective case review was conducted in 12 patients who underwent intact wall mastoidectomy tympanoplasty reconstruction autologous cortical bone.During follow-up, all obtained successful results on structures hearing improvement, except for one patient needed a revision operation fistula between reconstructed mastoid.Intact bone proved to be an effective...
Lassa virus (LASV) is a highly pathogenic that categorized as biosafety level-4 pathogen. Currently, there are no approved drugs or vaccines specific to LASV. In this study, high-throughput screening of fragment-based drug discovery library was performed against LASV entry using pseudotype bearing the envelope glycoprotein complex (GPC). Two compounds, F1920 and F1965, were identified inhibitors block GPC-mediated membrane fusion. Analysis adaptive mutants demonstrated transient L442F I445S,...