Abstract Fulminant hepatitis E may lead to acute liver failure (ALF). Perturbations of intestinal microbiota are related severe disease. To study the correlations between faecal and occurrence exacerbation virus (HEV) infection, we characterized 24 samples from 12 patients with (AHE) HEV‐ALF using high‐throughput sequencing. We found both alpha beta diversity indices showed no significant differences AHE groups. Several predominant taxa were significantly different Most notably, group had...

Diabetic cardiomyopathy (DCM) is a leading cause of mortality in patients with diabetes. We used both vitro and vivo experiments to investigate the hypothesis that sophocarpine (SPC), natural quinolizidine alkaloid derived from Chinese herb, could protect against DCM. hyperglycemic myocardial cells streptozotocin (STZ)-induced type 1 diabetes mellitus mouse model. SPC protected hyperglycemia-induced injury by improving mitochondrial function, suppressing inflammation, inhibiting cardiac...

An escalating pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has severely impacted global health. There is a lack of specific treatment options for diseases SARS-CoV-2. In this study, we used pseudotype virus (pv) containing SARS-CoV-2 S glycoprotein to screen botanical drug library 1037 drugs identify agents that prevent entry into cell. Our study identified four hits, including angeloylgomisin O, schisandrin B, procyanidin, and oleanonic acid, as...

Asthma is an airway chronic inflammatory disease with significant morbidity, mortality and huge social economic burden. Previous research demonstrated that the root of Aster tataricus (RA) may have potential to treat asthma, but efficacy mechanism were not clear. In this study, preliminary results in vitro showed Fr-75 eluted from RA extract could only completely inhibit tracheal ring contraction raised by KCl 20 min, also effectively affect induced KCl-, Ach- His a concentration-dependent...

Iron is an essential trace mineral required for growth, metabolism, and immune response. Dysregulation of iron homeostasis linked with the development progression various diseases. accumulation associated inflammatory diseases cancer, while deficiency leads to growth retardation. Several studies have suggested that imbalance results in alteration gut microbiota, leading disruption microbial diversity, increase pathogen abundance, induction intestinal inflammation. However, screening done...

Abstract Background Alzheimer's disease is a neurodegenerative disease. Previous study has reported that caspase-1/IL-1β closely associated with However, the biological role of in not been fully elucidated. This aimed to explore mechanism action Methods Mouse hippocampal neurones were treated Aβ 1-42 induce cell model. APP/PS1 mice and -induced AC-YVAD-CMK (caspase-1 inhibitor). Spatial learning memory ability detected by morris water maze. Flow cytometry, TUNEL staining, Thioflavin S...

Abstract Microglia polarization is associated with the pathogenesis of depression. A previous study shows that long non‐coding RNA uc.80‐ down‐regulated in hippocampus depressed rats. Thus, this article aims to investigate role microglia We first established depression model rats by chronic unpredictable mild stress (CUMS) regiment. found exhibited an increase M1 microglias and a decrease M2 microglias. was Furthermore, detection behaviouristics showed overexpression alleviated In addition,...

Cognitive deficits are core symptoms of schizophrenia, but effective treatments still lacking. Previous studies have reported that the brain-derived neurotrophic factor (BDNF) signaling is closely involved in learning and memory. Monosialotetrahexosylganglioside (GM1) a ganglioside with wide-ranging pharmacologic effects enhances BDNF cascade. This study aimed to assess GM1 on schizophrenia-related cognitive impairments. A brief disruption N-methyl-D-aspartate receptors MK801 was used...

It has been suggested that severity of the immune response induced by cells is associated with morbidity and mortality from acute pancreatitis. The authors investigated evaluated relationship between distinct peripheral lymphocyte subsets at admission clinical outcome prior to hospital discharge so as find a predictor prognosis pancreatitis in profile. Lymphocyte venous blood were tested through flow cytometry on 48 patients Clinical data was recorded well. primary observational outcomes...

To investigate the efficacy of enteric-coated Bifidobacterium triple viable capsules combined with enteral nutrition in treatment patients chronic critical illness (CCI) and their effects on immune coagulation function patients.106 CCI admitted to intensive care unit our hospital from December 2018 March 2020 were selected as research objects, they randomly divided into control group (n = 53) observation 53). The was given symptomatic treatment, etiological clinical nursing, support, other...

Abstract Background Recent basic studies demonstrate that the lung is a primary organ of platelet biogenesis. However, whether pathophysiological state affect platelets little known. We aim to investigate incidence thrombocytopenia in patients with pulmonary infection (PIN) and risk factors associated thrombocytopenia. Methods In total, 11,941 were enrolled, other three infectious diseases collected as controls. The was compared, PIN investigated by multivariate analysis. To explore...

<h3>Objectives:</h3> To compare the levels of plasma glutamate and glutamine in drug-resistant or drug-responsive symptomatic focal epilepsy. Dysfunctional neurotransmission plays an essential role epilepsy pathophysiology. <h3>Methods:</h3> This cross-sectional study included 80 42 epileptic patients 132 healthy controls from June 2017 to February 2018. Plasma were assessed via high-performance liquid chromatography. <h3>Results:</h3> Patients with had significantly higher than controls,...

Platelets play a crucial role in haemostasis and several pathophysiological processes. Collagen is main initiator for platelet activation aggregation. Given that Wnt signalling negatively regulates function, IWR-1 (a small molecule inhibitor signalling) has the potential of inhibiting collagen synthesis, it essential to investigate whether collagen-induced protects against thrombogenesis. In present study we found pretreatment effectively suppressed aggregation dose-dependent manner....

Colorectal cancer (CRC) is one of the lethal malignant tumors worldwide. However, underlying mechanism CRC and its biomarkers remain unclear. The aim this study was to identify key genes associated with further explore their prognostic significance.Four expression profile datasets (GSE41657, GSE74602, GSE113513, GSE40967) downloaded from Gene Expression Omnibus (GEO) RNAseq dataset Cancer Genome Atlas (TCGA) database were included in our study. Cox model utilized for univariate or...

We present here a CMOS islet of Langerhans. This circuit mimics the cellular dynamics pancreatic alpha and beta cells that control blood glucose levels, through release hormones glucagon insulin. system has been designed using human glycemic in vivo measurements mammalian vitro cell data. integrated silicon can form algorithm an artificial pancreas for patients with type 1 diabetes mellitus. The is 0.35 μm standard process; low-power, dissipating 78 μW, interface directly current output from...