A5101635335- Viral Infections and Outbreaks Research
- Plant Pathogens and Fungal Diseases
- Plant-Microbe Interactions and Immunity
- CAR-T cell therapy research
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Mosquito-borne diseases and control
- Hepatitis B Virus Studies
- Virus-based gene therapy research
- Weed Control and Herbicide Applications
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Plant Virus Research Studies
- Pharmacological Effects and Toxicity Studies
- Nematode management and characterization studies
- Mycotoxins in Agriculture and Food
- Renal Transplantation Outcomes and Treatments
- Pharmacogenetics and Drug Metabolism
- Plant Disease Management Techniques
- Plant Disease Resistance and Genetics
- Herpesvirus Infections and Treatments
- Legume Nitrogen Fixing Symbiosis
- Neuroscience and Neuropharmacology Research
- Bacillus and Francisella bacterial research
Institute of Plant Protection
2021-2025
Shandong Academy of Agricultural Sciences
2021-2025
Wuhan Institute of Virology
2020-2024
Vanderbilt University Medical Center
2002-2024
Chinese Academy of Sciences
2021-2024
Vanderbilt University
2002-2024
Nankai University
2020-2023
Zhengzhou Central Hospital
2019-2023
University of Chinese Academy of Sciences
2021
Pitié-Salpêtrière Hospital
2021
Abstract Tacrolimus has a narrow therapeutic window and considerable variability in clinical use. Our goal was to compare the performance of multiple linear regression (MLR) eight machine learning techniques pharmacogenetic algorithm-based prediction tacrolimus stable dose (TSD) large Chinese cohort. A total 1,045 renal transplant patients were recruited, 80% which randomly selected as “derivation cohort” develop dose-prediction algorithm, while remaining 20% constituted “validation test...
Biological seed dressing is a cost-effective means to protect plant roots from pathogens. Trichoderma generally considered as one of the most common biological dressings. However, there still dearth information on effects microbial community rhizosphere soil. High-throughput sequencing was used analyze viride and chemical fungicide soybean The results showed that both T. could significantly reduce disease index (15.11% for 17.33% Chemical), while no significant difference observed between...
Fusarium crown rot (FCR) is one of the most important soilborne diseases affecting wheat production. To investigate diversity pathogens causing this disease, 199 diseased samples were collected from 13 cities in Shandong province. In total, 468 isolates obtained, and these isolates, 11
Wheat Fusarium crown rot (FCR), mainly caused by pseudograminearum, is one of the most important diseases. Some mycoviruses are reported to have a hypovirulence trait and considered as biocontrol agent for plant fungal In cases, mycovirus biological effects not been explored clearly. this study, we identified characterized novel isolate double-stranded RNA (dsRNA) mycovirus, graminearum dsRNA 4 (FgV4), from new host, an WC9-2 F. pseudograminearum. The genome FgV4-WC9-2 includes two segments...
Objective: Lassa virus (LASV) glycoprotein complex (GPC) contains retained stable-signal peptide (SSP), 1 (GP1), and 2 (GP2). Through serial passaging of LASV with inhibitors, adaptive mutants were obtained, most which had mutations in the transmembrane (TM) domain GP2. Characterizing fusion inhibitor target within TM GP2 provided insights for development drugs vaccines. Methods: We conducted membrane fusion, IIH6 inhibition, thermostability, viral growth kinetics assays to characterize...
An escalating pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has severely impacted global health. There is a lack of specific treatment options for diseases SARS-CoV-2. In this study, we used pseudotype virus (pv) containing SARS-CoV-2 S glycoprotein to screen botanical drug library 1037 drugs identify agents that prevent entry into cell. Our study identified four hits, including angeloylgomisin O, schisandrin B, procyanidin, and oleanonic acid, as...
Abstract Chemotherapy was the main treatment method for esophageal cancer (EC) patients. However, chemotherapy resistance due to multiple factors is a major barrier EC treatment. For investigating how small nucleolar RNA host gene 6 (SNHG6) affected 5-fluorouracil (5-FU) in as well its possible molecular mechanism. This work conducted cell viability assay, clone formation, scratch assays together with apoptosis evaluating roles of SNHG6 and enhancer zeste homolog 2 (EZH2, histone-lysine...
Rapeseed (Brassica napus L.) is one of the most important oil crops almost all over world. Seed-related traits, including content (OC), silique length (SL), seeds per (SS), and seed weight (SW), are primary targets for yield improvement. To dissect genetic basis these 192 recombinant inbred lines (RILs) were derived from two parents with distinct length. High-density linkage map a total 1610.4 cM constructed using 1,329 double-digestion restriction site associated DNA (ddRAD) markers, 107...
The long non-coding RNA (lncRNA) SNHG6 was significantly upregulated in esophageal squamous-cell carcinoma (ESCC), and it promoted ESCC cell proliferation, invasion, migration. However, the effects of on apoptosis corresponding underlying mechanisms have not yet reported.Apoptosis detected by flow cytometric analysis. Quantitative real-time polymerase chain reaction (qRT-PCR) Western blotting were used for mRNA protein quantification, respectively. A luciferase reporter assay performed to...
The present study aimed to investigate the effects of melatonin (MLT) and 5‑fluorouracil (5‑FU) combination on chemotherapeutic effect 5‑FU in esophageal cancer, determine potential molecular mechanisms. MLT cell proliferation, migration invasion, apoptosis were detected by Cell Counting Kit‑8, Transwell assays flow cytometric analysis, respectively. Quantitative PCR western blotting performed for mRNA protein quantification, revealed that significantly inhibited activity a dose‑dependent...
The present study aimed to investigate the influence of circular RNA nuclear receptor‑interacting protein 1 (circNRIP1) on chemotherapeutic effect 5‑fluorouracil (5‑FU) in colorectal cancer (CRC) and reveal its potential molecular mechanisms. effects circNRIP1 cell proliferation, migration invasion, apoptosis were evaluated using Cell Counting Kit‑8, Transwell flow cytometric assays, respectively. A dual‑luciferase reporter assay was performed verify interaction between microRNA...
The acetylation of histone lysine residues regulates multiple life processes, including growth, conidiation, and pathogenicity in filamentous pathogenic fungi. However, the specific function each residue at N-terminus H3 phytopathogenic fungi remains unclear. In this study, we mutated N-terminal Fusarium pseudograminearum, main causal agent crown rot wheat China, which also produces deoxynivalenol (DON) toxins harmful to humans animals. Our findings reveal that all FpH3K9R, FpH3K14R,...
Wheat is a vital global food crop, yet it faces challenges in saline-alkali soils where Fusarium crown rot significantly impacts growth. Variations wheat growth across regions are often attributed to uneven terrain. To explore these disparities, we examined well-growing and poorly growing samples their rhizosphere soils. Measurements included height, root length, fresh weight, severity. Well-growing exhibited greater with lower disease index compared wheat. Analysis of soil revealed higher...
Recent results have suggested that some products of mercapturic acid pathway (MAP) metabolism oxidized dopamine (DA) may contribute to mesostriatal dopaminergic neurodegeneration, and at least one product, 5‐ S ‐cysteinyldopamine (Cys‐DA), is elevated in patients with advanced Parkinson's disease (PD) who been treated l ‐DOPA. Here we investigated MAP enzymes the midbrain striatum control individuals dementia Lewy bodies (DLB) had less severe degeneration than PD were not We also determined...
Retrospective studies suggest that chimeric antigen receptor T-cell (CAR T) therapy may lead to cardiac injury, but this has not been assessed systematically or prospectively. In prospective study of 40 patients who received CAR T, we measured high-sensitivity troponin T (hsTropT) and N-terminal pro-B natriuretic peptide (NTproBNP) at baseline on day 1, days 7, 21 after T. Biomarker elevations with respect timepoint cytokine release syndrome (CRS) status were examined using repeated measure...
Colorectal cancer (CRC) is the fourth most deadly worldwide, drug resistance impedes treatment of CRC. It still urgent to find new molecular targets improve sensitivity chemotherapeutic drugs. In this study, circ-ERBB2 was upregulated in CRC cells. Upregulation promoted cells proliferation and clone formation, but inhibited apoptosis. We identified miR-181a-5p as circ-ERBB2's target. The effect on contrary circ-ERBB2, downregulation abolished function silencing addition, phosphatase tensin...
Curcumin shows an anti-cancer role in many kinds of tumors. However, the mechanism its anti-tumor function esophageal squamous cell carcinoma (ESCC) remains largely unknown. Herein, we explored therapeutic potential curcumin for cancer. could time- and dose-dependently inhibit ESCC cells activity. Additionally, exposed to 20 μM exhibited significantly decreased proliferative invasive capacities, as well enhanced apoptosis. tissues increased circNRIP1 expression when compared their...