A5049531165- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Parasites and Host Interactions
- Organ Donation and Transplantation
- Cytomegalovirus and herpesvirus research
- Pharmacological Effects and Toxicity Studies
- Transplantation: Methods and Outcomes
- Renal Diseases and Glomerulopathies
- Cancer-related molecular mechanisms research
- Hepatitis C virus research
- Liver physiology and pathology
- Immune Cell Function and Interaction
- Drug Transport and Resistance Mechanisms
- MicroRNA in disease regulation
- Neurological Complications and Syndromes
- Pharmacological Effects of Natural Compounds
- Circular RNAs in diseases
- Gut microbiota and health
- T-cell and B-cell Immunology
- Organ and Tissue Transplantation Research
- Hepatitis B Virus Studies
- Complement system in diseases
- Pneumocystis jirovecii pneumonia detection and treatment
Central South University
2016-2025
Third Xiangya Hospital
2016-2025
Hunan Provincial Center for Disease Control and Prevention
2024-2025
Anhui Medical University
2025
Third People's Hospital of Hefei
2025
National Health and Family Planning Commission
2022-2024
Xiangya Hospital Central South University
2017-2022
Zhongnan Hospital of Wuhan University
2013-2019
Wuhan University
2013-2019
University of Florida
2019
Abstract Tacrolimus has a narrow therapeutic window and considerable variability in clinical use. Our goal was to compare the performance of multiple linear regression (MLR) eight machine learning techniques pharmacogenetic algorithm-based prediction tacrolimus stable dose (TSD) large Chinese cohort. A total 1,045 renal transplant patients were recruited, 80% which randomly selected as “derivation cohort” develop dose-prediction algorithm, while remaining 20% constituted “validation test...
Tacrolimus is used clinically for the long-term treatment of antirejection transplanted organs in liver and kidney transplant recipients, although dose optimization poorly managed. The aim this study was to examine association between tacrolimus pharmacokinetic variability CYP3A4 CYP3A5 genotypes by a population analysis based on routine drug monitoring data adult renal recipients.Trough concentrations were obtained from 161 recipients after transplantation. carried out using nonlinear...
Herpes simplex virus type 1 strain 129 (H129) has represented a promising anterograde neuronal circuit tracing tool, which complements the existing retrograde tracers. However, current H129 derived tracers are multisynaptic, neither bright enough to label details of neurons nor capable determining direct projection targets as monosynaptic tracer.Based on bacterial artificial chromosome H129, we have generated serial recombinant viruses for tracing. Among them, H129-G4 was obtained by...
Accumulating evidence shows that microRNAs (miRNAs) are involved in the development and progression of multiple tumors, including hepatocellular carcinoma (HCC). Recent studies have found miR-24 acts as an oncogene several tumors; however, function HCC remains unclear. In this study, we was increased tissues cell lines. Inhibition by inhibitor significantly suppressed cells proliferation, migration, invasion. Furthermore, sex-determining region Y (SRY)-box 7 (SOX7), a putative tumor...
Acute-on-chronic liver failure (ACLF) is a severe syndrome with high short-term mortality, but the pathophysiology still remains largely unknown. Immune dysregulation and metabolic disorders contribute to progression of ACLF, crosstalk between immunity metabolism during ACLF less understood. This study aims depict immune microenvironment in explore role lipid disorder on immunity.Single-cell RNA-sequencing (scRNA-seq) was performed using non-parenchymal cells (NPCs) peripheral blood...
Background Chronic gastrointestinal disorders, such as chronic constipation and diarrhea, pose significant public health challenges, affecting quality of life healthcare costs. Life’s Simple 7 (LS7), established by the American Heart Association, encompasses essential behaviors that may influence bowel health. Methods We utilized data from National Health Nutrition Examination Survey (NHANES) conducted between 2005 2010, focusing on adults aged 20 years older. A total 12,912 participants...
In kidney transplant recipients (KTRs), immune monitoring of peripheral lymphocyte subsets (PLS) reflects the real status and aids in diagnosis occurrence development infectious diseases, including COVID-19. Exploring PLS COVID-19 pneumonia KTRs is important. this study, a total 103 were divided into mild (MP) severe (SP) groups, as well stable group. The clinical information data assessed via t or Mann-Whitney test receiver operating curve analysis. Logistic regression was employed to...
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CD133 (prominin-1) is widely believed to be a cancer stem cell marker in various solid tumor types, and has been correlated with tumor-initiating capacity. Recently, the nuclear location of expression tumors discussed, but hepatocellular carcinoma (HCC) not included these discussions. The goal this study was investigate HCC location's potential value as prognostic indicator survival patients HCC. We enrolled 119 cancerous tissues pair-matched adjacent normal liver tissue from patients. These...
Congenital human cytomegalovirus (HCMV) infection is the leading cause of neurological disabilities in children worldwide, but mechanisms underlying these disorders are far from well-defined. HCMV has been shown to dysregulate Notch signaling pathway neural progenitor cells (NPCs). As an important downstream effector signaling, transcriptional regulator Hairy and Enhancer Split 1 (Hes1) essential for governing NPC fate fetal brain development. In present study, we report that downregulates...
Fulminant hepatic failure (FHF) refers to the rapid development of severe acute liver injury with impaired synthetic function and encephalopathy in people normal or well-compensated disease. This study aimed investigate long noncoding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) on proliferation apoptosis hepatocytes FHF. Our results revealed that lncRNA NEAT1 was upregulated cell animal models FHF induced by D-galactosamine (D-GalN)/lipopolysaccharide (LPS). Overexpression...
Despite the gradual decline of schistosomiasis due to efforts WHO and various countries, with setting a goal eliminate by 2030, comprehensive global assessment current status has not been conducted. To provide detailed description changes in from 1990 2019 using Global Burden Diseases, Injuries, Risk Factors Study (GBD) database. We obtained all relevant data on worldwide Diseases database 2019. The mortality, prevalence, disability-adjusted life-years (DALYs), Years Life Lost (YLLs), Lived...
Notch is an important signaling pathway that regulates cell fate, stem maintenance and the initiation of differentiation in many tissues. It has been reported activation Notch-1 contributes to tumorigenesis. However, whether might have a role chemoresistance prostate cancer unclear. This study aimed investigate effects silencing on sensitivity cells docetaxel treatment.siRNA against was transfected into PC-3 cells. Proliferation, apoptosis cycle distribution were examined presence or absence...
Gynostemma pentaphyllum is a traditional Chinese medicine that has previously been used for the treatment of chronic inflammation, hyperlipidemia and liver disease. Gypenoside (GP), predominant component pentaphyllum, exhibits therapeutic effect on hepatic injury, fibrosis fatty disease via its anti-inflammatory anti‑oxidant activity. However, GP ischemia/reperfusion (I/R)-induced injury has, to best our knowledge, not investigated. In present study, I/R‑injury model was successfully...
Ischemia-reperfusion (I/R) often leads to acute kidney injury, chronic renal failure and transplantation failure. Glycyrrhizin is extracted from Glycyrrhiza glabra roots the predominant active component, which exhibits anti-inflammatory effects. However, best of our knowledge, effect glycyrrhizin on I/R-induced injury has not been investigated. In present study, was demonstrated attenuate I/R in mice via administration glycyrrhizin, suppressed serum levels creatinine blood urea nitrogen 6 h...