A5100685810- Animal Virus Infections Studies
- Identification and Quantification in Food
- Monoclonal and Polyclonal Antibodies Research
- Metabolomics and Mass Spectrometry Studies
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Meat and Animal Product Quality
- Glycosylation and Glycoproteins Research
- Advanced Proteomics Techniques and Applications
- Insect and Pesticide Research
- Mass Spectrometry Techniques and Applications
- Breast Cancer Treatment Studies
- Biosensors and Analytical Detection
- HER2/EGFR in Cancer Research
- Bacteriophages and microbial interactions
- ATP Synthase and ATPases Research
- Parvovirus B19 Infection Studies
- Bacterial Identification and Susceptibility Testing
- Infant Nutrition and Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Sulfur-Based Synthesis Techniques
- Health, psychology, and well-being
- Biochemical and biochemical processes
National Chung Hsing University
2013-2025
Jinan Central Hospital
2016-2025
Anhui Medical University
2025
Second Hospital of Anhui Medical University
2025
Sichuan University
2024
West China Hospital of Sichuan University
2024
National Yang Ming Chiao Tung University
2020-2024
Binzhou University
2024
Binzhou Medical University
2024
East China Normal University
2024
Mounting studies have substantiated that abrogating autophagy contributes to cardiac hypertrophy (CH). Sirtuin 1 (SIRT1) has been reported support and inhibit CH. However, the upstream regulation mechanism behind of SIRT1 level in CH remains unclear. Circular RNAs (circRNAs) are vital modulators diverse human diseases including This study intended investigate regulatory circRNA on expression model was established by angiotensin II (Ang II) fusion or transverse aortic constriction (TAC)...
Abstract N6-methyladenosine (m 6 A), one of the most prevalent mRNA modifications in eukaryotes, plays a critical role modulating both biological and pathological processes. However, it is unknown whether mutant p53 neomorphic oncogenic functions exploit dysregulation m A epitranscriptomic networks. Here, we investigate Li-Fraumeni syndrome (LFS)-associated neoplastic transformation driven by iPSC-derived astrocytes, cell-of-origin gliomas. We find that but not wild-type (WT) physically...
<title>Abstract</title> <bold>Background and Objective:</bold> Current therapies for childhood T-cell acute lymphoblastic leukemia (T-ALL) have increased survival rates to about 85%. The standard of care is chemotherapy, but approximately 20% patients exhibit primary or secondary resistance current therapies. Parthenolide (PTL) has been shown excellent anti-cancer activity in pediatric xenografts, with minimal effects on normal hemopoietic cells. Some initiating cell populations remain...
RNA structures that are functionally important defined as cis-acting elements because their functions cannot be compensated for in trans. The the 3' UTR of coronaviruses replication; however, mechanism linking to replication function remains established. In present study, a comparison biological processes interactome and efficiency between coronaviruses, including severe acute respiratory syndrome coronavirus 2, suggests (i) processes, translation, protein folding stabilization, derived from...
Background Chronic gastrointestinal disorders, such as chronic constipation and diarrhea, pose significant public health challenges, affecting quality of life healthcare costs. Life’s Simple 7 (LS7), established by the American Heart Association, encompasses essential behaviors that may influence bowel health. Methods We utilized data from National Health Nutrition Examination Survey (NHANES) conducted between 2005 2010, focusing on adults aged 20 years older. A total 12,912 participants...
We evaluated HER-2 receptor status by immunocytochemical and immunohistochemical analyses fluorescence in situ hybridization (FISH) 51 fine-needle aspiration (FNA) specimens together with the corresponding formalin-fixed, paraffin-embedded (FFPE) tissue samples obtained from surgically resected breast cancers. Three fixation methods were compared: ethanol, formalin, CytoLyt-ThinPrep (Cytyc, Boxborough, MA). was overexpressed amplified 8 (16%) of FFPE specimens. Of cases, gene amplification...
Photoredox/nickel-catalyzed enantioconvergent acyl cross-coupling of carboxylic derivatives with racemic secondary organotrifluoroborate was developed for the synthesis an enolizable chiral α-aryl ketone under mild neutral conditions. Moderate to high yields and good enantioselectivities were achieved.
Liver cancer is one of the top three fatal types and it causes several thousands mortalities each year. The main treatment surgical resection which shows little benefit for patients with recurrence or metastasis. <em>NEIL3</em> promotes progression predicts survival in cancer. However, its role liver remains unclear. Based on data TCGA database, exhibited much higher expression tissues was clinically correlated tumor grade Furthermore, high caused shorter times. In cell lines, showed...
Abstract During coronavirus infection, in addition to the well-known genomes and subgenomic mRNAs, an abundance of defective viral (DVGs) can also be synthesized. In this study, we aimed examine whether DVGs encode proteins infected cells. Nanopore direct RNA sequencing liquid chromatography-tandem mass spectrometry (LC–MS/MS) analysis were employed. With protein databases generated by nanopore cell lysates derived from RNA–protein pull-down assay, six DVG-encoded identified LC–MS/MS based...
Abstract The K + uptake system KtrAB is essential for bacterial survival in low environments. activity of regulated by nucleotides and Na . Previous studies proposed a putative gating mechanism KtrB KtrA upon binding to ATP or ADP. However, how activates the site remain unknown. Here we present cryo-EM structures ATP- ADP-bound from Bacillus subtilis (BsKtrAB) both solved at 2.8 Å. A density intra-dimer interface ATP-KtrA was identified as , supported X-ray crystallography ICP-MS....
Over the past decades, proteomics has become increasingly important and a heavily discussed topic. The identification of intact proteins remains major focus in this field. While most are analyzed using high-resolution mass spectrometry, identifying them through low-resolution spectrometry continues to pose challenges. In our study, we investigated capability various collision-induced dissociation (CID) electron transfer without (ETnoD). Using myoglobin as test protein, stable product ions...
Lymphovascular invasion (LVI) is a micropathological tumor factor believed to increase the risk of metastasis and spread. Propensity score matching (PSM) statistical method that can control confounding factors. Current research rarely considers relationship between LVI other factors may influence prognosis. This study aimed investigate prognosis in patients with stage I-III colorectal cancer (CRC) by using propensity (PSM).This was retrospective involving 610 patients. PSM used adjust for...
Abstract Background In addition to the well-known coronavirus genomes and subgenomic mRNAs, existence of other RNA species, which are collectively referred as noncanonical transcripts, has been suggested; however, their biological characteristics have not yet experimentally validated in vitro vivo. Methods To comprehensively determine amounts, species structures transcripts for bovine HRT-18 cells mouse hepatitis virus A59, a coronavirus, L mice, nanopore direct sequencing was employed....
Geminiviruses are known to exhibit both prokaryotic and eukaryotic features in their genomes, with the ability express genes even replicate bacterial cells. We have demonstrated previously existence of unit-length single-stranded circular DNAs Ageratum yellow vein virus (AYVV, a species genus Begomovirus, family Geminiviridae) Escherichia coli cells, which prompted our search for unknown functions begomovirus genomes. By using promoter trapping strategy, we identified novel promoter,...
Rationale Oriental Beauty, a type of oolong tea native to Taiwan, is highly prized by connoisseurs for its unique fruity aroma and sweet taste. Leaves Beauty vary in appearance, aroma, taste, depending on the degree green leafhopper ( Jacobiasca formosana ) infestation. In this study, aim investigate differential expression proteins leaves with low, medium, high degrees Methods Proteomic techniques 2DE (two‐dimensional electrophoresis) nanoscale liquid chromatography/tandem mass spectrometry...
We evaluated HER-2 receptor status by immunocytochemical and immunohistochemical analyses fluorescence in situ hybridization (FISH) 51 fine-needle aspiration (FNA) specimens together with the corresponding formalin-fixed, paraffin-embedded (FFPE) tissue samples obtained from surgically resected breast cancers. Three fixation methods were compared: ethanol, formalin, CytoLyt-ThinPrep (Cytyc, Boxborough, MA). was overexpressed amplified 8 (16%) of FFPE specimens. Of cases, gene amplification...