A5018747484- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Supramolecular Chemistry and Complexes
- Molecular Sensors and Ion Detection
- RNA modifications and cancer
- Mass Spectrometry Techniques and Applications
- Chemical Synthesis and Analysis
- Circular RNAs in diseases
- Advanced Proteomics Techniques and Applications
- Luminescence and Fluorescent Materials
- Metabolomics and Mass Spectrometry Studies
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
- Crystallography and molecular interactions
- Signaling Pathways in Disease
- Cancer-related gene regulation
- RNA and protein synthesis mechanisms
- Porphyrin and Phthalocyanine Chemistry
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Metabolism and Genetic Disorders
- Ubiquitin and proteasome pathways
- SARS-CoV-2 and COVID-19 Research
- Supramolecular Self-Assembly in Materials
- Systemic Lupus Erythematosus Research
National Chung Hsing University
2016-2025
China Medical University
2014-2024
National Yang Ming Chiao Tung University
2013-2024
China Medical University Hospital
2011-2021
National Taipei University
2010-2020
National Defense Medical Center
2019-2020
Taipei Veterans General Hospital
2012-2017
Chi Mei Medical Center
2011-2017
China Medical University
2014-2017
University of Cagliari
2016
Abstract Promyelocytic leukemia nuclear bodies (PML-NBs) are PML-based structures that regulate various cellular processes. SUMOylation, the process of covalently conjugating small ubiquitin-like modifiers (SUMOs), is required for both formation and disruption PML-NBs. However, detailed mechanisms how SUMOylation regulates these processes remain unknown. Here we report SUMO5, a novel SUMO variant, mediates growth PolySUMO5 conjugation PML at lysine 160 facilitates recruitment PML-NB...
Abstract Myeloid cell leukemia-1 (Mcl-1), a Bcl-2–like antiapoptotic protein, plays role in immortalization and chemoresistance number of human malignancies. A peptidyl-prolyl cis/trans isomerase, Pin1 is involved many cellular events, such as cycle progression, proliferation, differentiation through isomerizing prophosphorylated substrates. It has been reported that down-regulation induces apoptosis, Erk phosphorylates up-regulates Mcl-1; however, the underlying mechanisms for two phenomena...
Vying for urea: The translational isomerism of a neutral [2]rotaxane can be controlled in solution through the addition and removal acetate anions. In absence ions, macrocyclic host recognizes diphenylurea derivative; recognition ions by urea-based station causes relocation macrocycle to another binding site (see picture). Supporting information this article is available on WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z702197_s.pdf or from author. Please note: publisher not...
EGF induces the translocation of receptor (EGFR) from cell surface to nucleus where EGFR activates gene transcription through its binding an AT-rich sequence (ATRS) target promoter. However, how EGFR, without a DNA-binding domain, can bind promoter is unclear. In present study, we show that RNA helicase A (RHA) important mediator for EGFR-induced transactivation. stimulates interaction with RHA in cancer cells. The EGFR/RHA complex then associates ATRS activate transcription. Knockdown...
The mammalian constitutive photomorphogenesis 9 (COP9) signalosome (CSN), a protein complex involved in embryonic development, is implicated cell cycle regulation and the DNA damage response. Its role tumor however, remains unclear. Here, we have shown that COP9 subunit 6 (CSN6) gene amplified human breast cancer specimens, CSN6 upregulated thyroid tumors. expression positively correlated with of murine double minute 2 (MDM2), potent negative regulator p53 suppressor. Expression appeared to...
A switch in time: Gel–sol transitions of a urea-based [2]rotaxane gelator are controlled by the degree solvent exposure hydrogen-bond-donating urea station and orientation hydrogen-bond-accepting CO groups interlocked ethylene glycol based macrocycle (N blue, O red, phenyl green). Both acid/base anion-exchange control can be used to reversibly transition rotaxane 1-pentanol between solution gel states.
We report a molecular cage-based [2]rotaxane that functions as an artificial muscle through the control of addition and removal fluoride anions. The percentage change in length is about 36% between stretched contracted states, which larger than (∼27%) human muscle.
This study investigated the correlation between antibiotic consumption and antimicrobial resistance in Gram-negative bacteria causing healthcare-associated infections at a university hospital Taiwan from 2000 to 2009.Disc susceptibility data of Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, Proteus spp., Pseudomonas aeruginosa, Acinetobacter Stenotrophomonas maltophilia other non-fermentative bacilli were evaluated. Data on annual patient-days (defined...
Abstract Epithelial-to-mesenchymal transition (EMT) is an essential physiologic process that promotes cancer cell migration, invasion, and metastasis. Several lines of evidence from both cellular genetic studies suggest AKT1/PKBα, but not AKT2 or AKT3, serves as a negative regulator EMT breast However, the underlying mechanism by which AKT1 suppresses remains poorly defined. Here, we demonstrate phosphorylation Twist1 required for β-TrCP–mediated ubiquitination degradation. The clinically...
Growth and productivity of rice (Oryza sativa L.) are severely affected by salinity. Understanding the mechanisms that protect other important cereal crops from salt stress will help in development salt-stress-tolerant strains. In this study, seedlings same genetic species with various tolerances were studied. We first used 2DE to resolve expressed proteome roots leaves then nanospray liquid chromatography/tandem mass spectrometry identify differentially proteins after treatment. The assays...