A5045415378- Healthcare Policy and Management
- Global Maternal and Child Health
- Cancer Cells and Metastasis
- Global Health Care Issues
- Healthcare Systems and Reforms
- Immunotherapy and Immune Responses
- Child Nutrition and Water Access
- Veterinary Practice and Education Studies
- Innovations in Medical Education
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Patient Satisfaction in Healthcare
- Organizational Strategy and Culture
- Empathy and Medical Education
- Health disparities and outcomes
- Advanced Breast Cancer Therapies
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Medical Malpractice and Liability Issues
- Global Healthcare and Medical Tourism
- Hedgehog Signaling Pathway Studies
- Axon Guidance and Neuronal Signaling
- Telomeres, Telomerase, and Senescence
- Travel-related health issues
- Online and Blended Learning
Taipei Medical University
2014-2024
University of Taipei
2024
The University of Texas MD Anderson Cancer Center
2014-2021
National Taiwan University
2021
Houston Methodist
2018
Mildmay Uganda
2016
National Yang Ming Chiao Tung University
2010
Enriched PD-L1 expression in cancer stem-like cells (CSCs) contributes to CSC immune evasion. However, the mechanisms underlying enrichment CSCs remain unclear. Here, we demonstrate that epithelial-mesenchymal transition (EMT) enriches by EMT/β-catenin/STT3/PD-L1 signaling axis, which EMT transcriptionally induces N-glycosyltransferase STT3 through β-catenin, and subsequent STT3-dependent N-glycosylation stabilizes upregulates PD-L1. The axis is also utilized general cell population, but it...
Chimeric antigen receptor (CAR)-modified T cell therapy has the potential to improve overall survival of patients with malignancies by enhancing effectiveness CAR cells. Precisely predicting various cells represents one today's key unsolved problems in immunotherapy. Here, we predict CAR-modified evaluating quality CAR-mediated immunological synapse (IS) quantitation F-actin, clustering tumor antigen, polarization lytic granules (LGs), and distribution signaling molecules within IS....
Abstract Epithelial-to-mesenchymal transition (EMT) is an essential physiologic process that promotes cancer cell migration, invasion, and metastasis. Several lines of evidence from both cellular genetic studies suggest AKT1/PKBα, but not AKT2 or AKT3, serves as a negative regulator EMT breast However, the underlying mechanism by which AKT1 suppresses remains poorly defined. Here, we demonstrate phosphorylation Twist1 required for β-TrCP–mediated ubiquitination degradation. The clinically...
Abstract Triple-negative breast cancer (TNBC) is a highly heterogeneous and recurrent subtype of that lacks an effective targeted therapy. To identify candidate therapeutic targets, we profiled global gene expression in TNBC tumor-initiating cells with patient survival dataset. Eight TNBC-related kinases were found to be overexpressed stem-like properties. Among them, PKC-α, MET, CDK6 correlated poorer outcomes. In cases coexpressing two these three kinases, rates lower than where only one...
Despite the progress in Millennium Development Goals (MDGs) 4 and 5, inequity utilization of maternal, newborn child health (MNCH) care services still remain high sub-Saharan Africa (SSA). The continuum for MNCH that recognizes a tight inter-relationship between at different time periods location is key towards reducing health. In this study, we explored distributions 12 SSA countries further investigated associations MNCH.Using Demographic Health Surveys data SSA, structural equation...
The oncogenic transcription factor Gli1 is a critical effector in the Hedgehog (Hh) pathway, which necessary for development and progression of pancreatic ductal adenocarcinoma (PDAC). Although TGFβ K-Ras are known regulators gene this setting, it not understood how functional activity regulated. Here, we report identification as substrate protein arginine N-methyltransferase PRMT1 PDAC. We found that methylates at R597, promoting its transcriptional by enhancing binding to target promoters....
Abstract Purpose: Surgical resection is considered as a curative treatment modality for hepatocellular carcinoma; however, the incidence of postoperative tumor recurrence high, leading to worse patient survival. Persistent hepatitis (inflammation) one risk factors after surgical resection. The aim this study investigate underlying mechanisms linking liver inflammation carcinoma progression. Experimental Design: In study, we used cytokine array identify important cytokines whose levels are...
Abstract Human ribonuclease 1 (hRNase 1) is critical to extracellular RNA clearance and innate immunity achieve homeostasis host defense; however, whether it plays a role in cancer remains elusive. Here, we demonstrate that hRNase 1, independently of its ribonucleolytic activity, enriches the stem-like cell population enhances tumor-initiating ability breast cells. Specifically, secretory binds activates tyrosine kinase receptor ephrin A4 (EphA4) signaling promote tumor initiation an...
Pituitary tumor transforming gene (PTTG1, securin) is involved in cell-cycle control through inhibition of sister-chromatid separation. Elevated levels PTTG1 were found to be associated with many different types that might late stage progression. However, the role early tumorigenesis unclear. Here we utilized adenovirus expression system deliver into normal human fibroblasts evaluate tumorigenesis. Expressing inhibited cell proliferation. Several senescence-associated (SA) phenotypes...
The objective of this study was to understand and estimate the complex relationships in continuum care for maternal health provide information improve newborn outcomes. Women (n = 4,082) aged 15-49 years 2008/2009 Kenya Demographic Health Survey data were used explore (i.e., before, during, after delivery) using structural equation modeling. Results showed that use antenatal significantly positively related delivery (β 0.06; adjusted odds ratio [AOR] 1.06; 95% confidence interval [CI]:...
The main objective of this study is to investigate the outcome between surgical procedures and risk development hypoparathyroidism followed by procedure in patients with thyroid disorders. We analyzed data acquired from Taiwan's Bureau National Health Insurance (BNHI) research database 1998 2011 found 9316 surgery. Cox regression model was used calculate hazard ratio (HR). A count 314 cases (3.4%) identified. 9 years cumulated incidence highest patient undergone bilateral total thyroidectomy...
In the ever-evolving landscape of healthcare, convergence artificial intelligence (AI) within breast cancer screening and transformative potential natural language processing (NLP) in ensuring patient safety stands as a testament to ground-breaking progress.[1 2][1] The seamless
Background Health care resource allocation is key towards attaining equity in the health system. However, professionals' perceived impact and attitude Sub-Saharan Africa unknown; furthermore, they occupy a position which makes them notice of different policies their This study explored perceptions attitudes professionals Kenya on mechanism. Method We conducted survey representative sample 341 Moi Teaching Referral Hospital from February to April 2012, consisting over 3000 employees. assessed...
Features of the health care delivery system may not be only expounding factors adequate utilization antenatal among women. Other social such as family structure and its environment contribute toward pregnant women's care. An understanding how women in different types groups use basic maternal services is important developing implementing policy post-Millennium Development Goal era, especially sub-Saharan Africa where mortality still remains high.
Objective The early identification of subjects at high risk for diabetes is essential, thus, random rather than fasting plasma glucose more useful. We aim to evaluate the time interval between pre-diabetes with anti-diabetic drugs by using HbA1C as a diagnostic tool, and predicting it mathematic model. Methods used Taipei Medical University Affiliated Hospital Patient Profile Database (AHPPD) from January-2007 June-2011. patients who progressed were prescribed selected AHPPD. mathematical...
Helicobacter pylori is a major risk factor for gastritis, gastric ulcers and cancer. Traditional therapy with proton pump inhibitor antibiotics regarded as optimal H. eradication whereas, the rate unsatisfactory. Studies have reported that cranberry may inhibit adhesion to human mucus but lack of other berry extracts been evaluated in clinical study. Thus, 9-week add-on randomised controlled trial was conducted explore impact blueberry grape seed extract (BGE) combinations traditional...
The objective of this study was to evaluate productivity growth and quality changes among different levels accredited hospitals. This used an attribute-incorporating Malmquist index (MPI) under the metafrontier framework. is first attempt compare hospitals operating production frontiers. data consisted 20 academic medical centers (AMCs), 61 metropolitan (MPs) 112 local community (LCs) in Taiwan during period 2007–2010. measured further identified technological gaps catch-ups groups with...
To measure inequality in physician distributions using Gini coefficient and spatially adjusted coefficients.Measurements were based on the distribution of data from Taiwan National Health Insurance Research Database (NHIRD) population Ministry Interior Taiwan.The physicians 2001 to 2010.This study considered 35 000 who are registered Taiwan.To calculate coefficients 2010.The for each year, 2010, ranged 0.5128 0.4692, while travel time distance ranged, respectively, 0.4324 0.4066 0.4408...
The primary goals of this study are to profile the strategic behaviours Taiwan's hospitals under National Health Insurance programme, identify related factors for such behaviours, and assess influences hospitals' on their performance. Findings indicate that most prevalent strategy adopted by is alliance. results demonstrate hospital level a predictor strategies employed hospitals. Furthermore, findings also reveal although embraced alliance, executives perceive focus differentiation ones...
Medical disputes in veterinary practices are widespread; yet, a limited amount of research has been conducted to investigate the factors contributing medical disputes. This study examined veterinarians’ and clients’ perceptions regarding risk possible solutions A total 245 respondents from Taiwan, including 125 veterinarians 120 clients, completed an electronic self-administered, semi-structured questionnaire 2022. The covered six dimensions: skills, complaint management, attitudes...