A5013139941- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Influenza Virus Research Studies
- Advancements in Battery Materials
- Gout, Hyperuricemia, Uric Acid
- Rheumatoid Arthritis Research and Therapies
- Myasthenia Gravis and Thymoma
- Epigenetics and DNA Methylation
- Advanced battery technologies research
- Animal Disease Management and Epidemiology
- Advanced Battery Materials and Technologies
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Inflammasome and immune disorders
- Animal Genetics and Reproduction
- Respiratory viral infections research
- RNA modifications and cancer
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Cancer-related gene regulation
- Electrocatalysts for Energy Conversion
- Viral gastroenteritis research and epidemiology
- Virology and Viral Diseases
Sichuan University
2017-2025
Fudan University
2021-2025
West China Second University Hospital of Sichuan University
2019-2025
China Medical University
2019-2025
Yangzhou University
2022-2025
Ludong University
2022-2025
Shunde Polytechnic
2024
Ministry of Agriculture and Rural Affairs
2024
Qingdao University of Science and Technology
2024
Ministry of Education of the People's Republic of China
2022-2024
Glycosylation of immune receptors and ligands, such as T cell receptor coinhibitory molecules, regulates signaling activation surveillance. However, how oncogenic initiates glycosylation molecules to induce immunosuppression remains unclear. Here we show that IL-6-activated JAK1 phosphorylates programmed death-ligand 1 (PD-L1) Tyr112, which recruits the endoplasmic reticulum-associated N-glycosyltransferase STT3A catalyze PD-L1 maintain stability. Targeting IL-6 by antibody induced...
Conventional therapies for breast cancer brain metastases (BCBMs) have been largely ineffective because of chemoresistance and impermeability the blood-brain barrier. A comprehensive understanding underlying mechanism that allows cells to infiltrate is necessary circumvent treatment resistance BCBMs. Here, we determined expression a long noncoding RNA (lncRNA) named lncRNA associated with BCBM (Lnc-BM) prognostic progression metastasis in patients. In preclinical murine models, elevated...
The development of new energy storage technology has played a crucial role in advancing the green and low-carbon revolution. This led to significant progress, spanning from fundamental research its practical application industry over past decade. Nevertheless, constrained performance materials poses challenge, as current electrochemical systems may struggle meet growing market demand. In recent years, carbon derived biomass garnered attention because customizable physicochemical properties,...
The hypoxic tumor environment has been shown to be critical cancer metastasis through the promotion of angiogenesis, induction epithelial-mesenchymal transition (EMT), and acquisition invasive potential. However, impact hypoxia on expression profile proteolytic enzymes involved in invasiveness is relatively unknown. Membrane-type 4 matrix metalloproteinase (MT4-MMP) a glycosyl-phosphatidyl inositol-anchored protease that overexpressed human cancers. detailed mechanisms regarding regulation...
Although several individual nutrients/foods are associated with uric acid status, the association of overall diet quality hyperuricemia remains unclear. The current study was undertaken to examine between adherence Dietary Approaches Stop Hypertension (DASH) and odds having in a Chinese adult population.Included were 71,893 participants Kailuan I II (mean age 51.4 years) who free gout prior or 2014. intakes assessed using validated food frequency questionnaire, DASH score calculated based on...
Abstract Developing advanced electrocatalysts is crucial for alkaline hydrogen evolution reaction (HER). A balance in adsorption energy each intermediate on the catalyst determines overall catalytic rate. This closely linked to d‐band center, which is, turn, controlled by electronic structure of active sites. Herein, C 60 molecules with electron‐withdrawing properties and manganese (Mn) atoms electron‐donating drive charge redistribution Ru sites are strategically utilized. The synergistic...
For patients with advanced or metastatic Hepatocellular carcinoma (HCC) who are not suitable for surgical resection, systemic therapy has been considered to be the standard treatment. In recent years, a small subset of unresectable HCC have benefit from tyrosine kinase inhibitors (TKIs), and overall survival time these is significantly increased. However, all responders ultimately develop resistance TKI The tripartite motif (TRIM) family member TRIM15 acts as an E3 ligase mediate...
A type of colorectal cancer (CRC)，Colitis-associated (CAC)， is closely associated with chronic inflammation and gut microbiota dysbiosis. Berberine (BBR) has a long history in the treatment intestinal diseases, which been reported to inhibit colitis CRC. However, mechanism its action still unclear. Here, this study aimed explore potential protective effects BBR on azoxymethane (AOM)/dextransulfate sodium (DSS)-induced tumor mice, elucidate molecular mechanisms by microbiota, genes metabolic...