A5100435491- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Birth, Development, and Health
- Congenital Heart Disease Studies
- Diet and metabolism studies
- Science, Research, and Medicine
- Congenital heart defects research
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Renal and Vascular Pathologies
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Adipokines, Inflammation, and Metabolic Diseases
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Vitamin D Research Studies
- Fatty Acid Research and Health
- Gastrointestinal Bleeding Diagnosis and Treatment
- Liver Disease and Transplantation
- Cytokine Signaling Pathways and Interactions
- Genomics and Phylogenetic Studies
- Cancer Immunotherapy and Biomarkers
- Clostridium difficile and Clostridium perfringens research
- Inflammasome and immune disorders
- Pediatric health and respiratory diseases
Nanjing Medical University
2021-2025
Nanjing University
2021-2025
Nanjing General Hospital of Nanjing Military Command
2024-2025
Ningbo University
2025
Beijing Children’s Hospital
2016-2024
Capital Medical University
2014-2024
Center for Children
2024
Beijing Anzhen Hospital
2009-2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2024
Shandong University of Science and Technology
2021-2023
Abstract Elucidating the mechanisms by which short chain fatty acids (SCFA) reduce body weight may assist in development of an effective control strategy. Dietary supplementation acetate, propionate, butyrate or their admixture was shown to significantly inhibit gain induced high-fat diet feeding. Supplementation SCFAs caused significant changes expressions G-protein coupled receptor 43 (GPR43) and GPR41 characterized increases adipose tissue reductions colon. Additionally, they influenced...
Conventional therapies for breast cancer brain metastases (BCBMs) have been largely ineffective because of chemoresistance and impermeability the blood-brain barrier. A comprehensive understanding underlying mechanism that allows cells to infiltrate is necessary circumvent treatment resistance BCBMs. Here, we determined expression a long noncoding RNA (lncRNA) named lncRNA associated with BCBM (Lnc-BM) prognostic progression metastasis in patients. In preclinical murine models, elevated...
Abstract Objective This study was to inspect the antidepressant‑like effect of prebiotics and probiotics, explore modulating gut microbiota on serotonin (5‐HT) metabolism. Methods Fifty rats were separated into control other four groups randomly. The underwent chronic unpredictable mild stress (CUMS) intervention with or without probiotics ( Bifidobacterium longum , L. rhamnosus ) treatment. After weighted, animals a series behavioral tests comprising sucrose preference test (SPT) forced...
Lung adenocarcinoma (LAC), the primary histological type of non-small cell lung cancer (NSCLC), has displayed an increasing incidence and mortality worldwide. However, therapeutic approaches were limited. Dysregulation some lncRNAs been shown in various types cancers including LAC. The aim present study was to vertify lncRNA DLX6-AS1 expression LAC.Microarray assay revealed profile qRT-PCR ( quantitative reverse transcription PCR) performed identify level 72 paired LAC adjacent normal...
Abstract Background Adiponectin and resistin are typically secreted by the adipose tissue abnormally expressed in obesity. However, underlying influential factors mechanisms to be elucidated. It is well known that expression of genes regulated epigenetics while gut microbiota participates epigenetic processes through its metabolites such as folate, biotin, short-chain fatty acids (SCFAs). Therefore, we supposed alteration might affect transcriptional adiponectin regulation Methods C57BL/6J...
The dysregulation of NLRP3 inflammasome plays a critical role in pathogenesis various human inflammatory diseases, thus activation must be tightly controlled at multiple levels. However, the underlying mechanism regulating remains unclear. Herein, effects Tripartite motif-containing protein 65 (TRIM65) on and molecular were investigated vitro vivo . Inhibition or deletion Trim65 could significantly strengthen agonist induced THP-1 cells BMDMs, indicated by increased caspase-1 interleukin-1β...
Acute myocardial infarction (MI) and ischemic heart disease are the leading causes of failure mortality. Currently, research on MI treatment is focused angiogenic anti-inflammatory therapies. Although endothelial cells (ECs) critical for triggering inflammation angiogenesis, no approach has targeted them MI. In this study, we proposed a nonviral combined nucleic acid delivery system consisting an EC-specific polycation (CRPPR-grafted ethanolamine-modified poly(glycidyl methacrylate), CPC)...
Abstract Specific adipokines, such as adiponectin and resistin, are secreted from adipose tissue associated with the development of obesity. Supplementation dietary SCFA can prevent reverse high-fat-diet (HFD)-induced However, it is not clear whether ameliorate abnormal expression resistin in obese state. The aim this study was to investigate effects on resistin’s expressions diet-induced mice, well potential mechanisms DNA methylation. C57BL/6J male mice were fed for 16 weeks five types HFD...
Abstract Background Early-life antibiotic exposure is associated with the development of later obesity through disruption gut microbiota in animal models. However, related epidemiological evidence still conflicting. Methods A birth cohort was consisted 2140 mother-infant pairs Chaoyang District Maternal and Child Health Care Hospital this study. Here, their available during first one year life ascertained using a open-ended questionnaire anthropometric parameters from health screening...
The tumor environment is of vital importance for the incidence and development colorectal cancer. Increasing evidence in recent years has elaborate role cancer-subtype classification patients' prognosis, but a comprehensive understanding purely depending on stromal compartment lacking. To decipher features cancer explore its immune context composition classification, we performed gene expression microarray microdissection-processed compartments adjacent normal tissues. Through integrated...
Quantitative PCR (qPCR), the most accurate and sensitive technique for quantifying mRNA expression, choice of appropriate reference genes internal error controlling in qPCR are essential to understanding molecular mechanisms that drive obesity epidemic its comorbidities. In this study, using high-fat diet (HFD)-induced obese mouse model, we assessed expression 10 commonly used validate gene-expression stability adipose tissue, liver, muscle across different time points (4, 8, 12, 16 weeks...
Abstract Bile salt hydrolases (BSHs) are enzymes that essential for the enterohepatic metabolism of bile acids (BAs). BSHs catalyze production unconjugated BAs and regulate homeostasis BA pool. This study identified Lactobacillus as a crucial BSH‐encoding genus, 16 main species were obtained using metagenomic data from publicly available human gut microbiome databases. Then, lactobacilli classified into four typical categories by BSH phylotypes, including five encoding BSH‐T0, six BSH‐T2,...
Recent advancements in plasma lipidomes genome-wide association studies data have enhanced our understanding of lipid categories, significantly improving risk assessments for metabolic dysfunction-associated fatty liver disease (MAFLD) beyond traditional biomarkers. This study utilized Mendelian randomization (MR) to assess the causal relationships between 179 species across 13 subclasses and MAFLD, primarily using Wald ratio IVW methods. Corrections were made false discovery rate (FDR),...
Vein grafts in a coronary bypass or hemodialysis access often develop obliterative growth of the neointima. We previously reported that mechanical stretch-activated insulin-like factor-1 receptor (IGF-1/IGF-1R) pathway plays an important role this remodeling. However, transcriptional mechanism(s) regulating IGF-1R expression and neointima formation have not been identified.Deletion site-specific mutagenesis analysis promoter identified minimal mechano-responsive element (-270--130) contains...
Gastric cancer (GC) is one of the major global health problems, especially in Asia. Nowadays, long non-coding RNA (lncRNA) has gained significant attention current research climate such as carcinogenesis. This desires to explore mechanism Prader–Willi region non-protein coding 1 (PWRN1) on regulating GC process. Differentially expressed lncRNAs tissues were screened out through microarray analysis. The and protein expression level detected by quantitative real-time PCR (qRT-PCR) Western...
Hepatocellular carcinoma (HCC) is a primary liver cancer with 5-year incidence of over 70%. Anisodamine (ANI), an alkaloid extracted from Anisodus, has good therapeutic effect in septic shock and morphine addiction. Our study designed to investigate the anticancer anisodamine (ANI) on HCC.HepG2 cells were subcutaneously injected into BALB/C nude mice tumor tissue was inoculated construct transplanted tumor. Mice randomly divided 10 groups (n = 5): control group, ANI-10 ANI-50 ANI-200...