A5100386478- Nanoparticle-Based Drug Delivery
- Gut microbiota and health
- RNA Interference and Gene Delivery
- Advanced Drug Delivery Systems
- Microbial Metabolic Engineering and Bioproduction
- Natural product bioactivities and synthesis
- Alzheimer's disease research and treatments
- Biopolymer Synthesis and Applications
- Phytochemistry and Biological Activities
- Nanoplatforms for cancer theranostics
- Enzyme Catalysis and Immobilization
- Advanced biosensing and bioanalysis techniques
- NF-κB Signaling Pathways
- MicroRNA in disease regulation
- Clostridium difficile and Clostridium perfringens research
- Extracellular vesicles in disease
- Phytochemical Studies and Bioactivities
- Galectins and Cancer Biology
- Phytochemical and Pharmacological Studies
- Phytochemistry and Bioactive Compounds
- biodegradable polymer synthesis and properties
- Bioactive natural compounds
- Steroid Chemistry and Biochemistry
- Hydrogels: synthesis, properties, applications
- Biochemical Acid Research Studies
The People's Hospital of Guangxi Zhuang Autonomous Region
2023-2025
Shandong University
2024
State Key Laboratory of Microbial Technology
2024
Ningbo University Affiliated Hospital
2024
Jiangnan University
2017-2024
Wuhan University
2024
Hubei Provincial Center for Disease Control and Prevention
2024
Zhongnan Hospital of Wuhan University
2024
Nanjing Agricultural University
2023
Chongqing Jiulongpo People's Hospital
2023
Purpose: Lung cancer has a high incidence rate worldwide with 5-year survival of 18%, and is the leading cause cancer-related deaths. The aim this study to augment therapeutic efficacy quercetin (QR) for lung therapy by targeting transferrin receptors, which are overexpressed confined tumor cells. Methods: In study, T7 surface-functionalized liposomes loaded QR (T7-QR-lip) having different peptide densities (0.5%, 1% 2%) were prepared film hydration method. characterized evaluated in terms...
Ulcerative colitis (UC) is associated with brain neurotransmitter disorders and intestinal dysbiosis. Bacillus amyloliquefaciens fmb50 produces the lipopeptide surfactin, which has a wide range of biological activities. However, effects surfactin on DSS-induced have not been reported. In present study, oral significantly ameliorated in mouse model reduced depression-like behavior, such as slowed walking speed, shortened movement distance open field test, weakened exploration ability...
Type 2 diabetes mellitus (T2DM) is associated with liver dysfunction and intestinal dysbiosis. Bioactive peptides (BAPs) have been reported to ameliorate T2DM by preventing oxidative damage the liver. Bacillus amyloliquefaciens fmb50 produces lipopeptide surfactin a wide range of biological activities. The effects on T2DM, other hand, not studied. In present study, 80 mg/kg body weight supplementation lowered fasting blood glucose (FBG) levels 21.05 % insulin resistance (IR) 18.18 compared...
Abstract Crocetin (CRT) has shown various neuroprotective effects such as antioxidant activities and the inhibition of amyloid β fibril formation, thus is a potential therapeutic candidate for Alzheimer’s disease (AD). However, poor water solubility bioavailability are major obstacles in formulation development pharmaceutical applications CRT. In this study, novel water-soluble CRT-γ-cyclodextrin inclusion complex suitable intravenous injection was developed. The nontoxic to normal...
Astilbin, a flavonoid compound, was isolated from the rhizome of Smilax glabra Roxb. (with red cross-section) grown in Guizhou Province, China. We accessed its effect and potential mechanism on attenuation inflammatory response CFA-induced AA rats. Our results showed that daily oral administration astilbin at 5.3 mg/kg reduced joint damage hind paw Accordingly, exhibited remarkable inhibitory effects TNF-α, IL-1β, IL-6 mRNA expression. Significant decrease serum cytokine levels also observed...
Repeated administrations of insulin injection on daily basis evoke pain and numerous complications with adverse effects the diabetic patients' life quality. Moreover, wearing pump is also associated several problems ketoacidosis, catheter site infection, contact dermatitis high cost.We have developed an in situ gel system, consisting insulin-loaded liposomes dispersed within a thermoreversible (Pluronic® F127 gel), which increases duration action for treatment diabetes. Vesicular...
(Appeared originally in the International Journal of Molecular Sciences 2019; 20:381) Reprinted under Creative Commons CC-BY license.
Carbon sources alter the synthesis of exopolysaccharides (EPS) in Lactiplantibacillus plantarum. Maltose increased EPS production L. plantarum 163 6.5-fold. Subsequently, production, transcriptome, and proteome were analyzed using glucose or maltose to further clarify regulatory mechanism. A cAMP receptor protein (UniProtKB: F9UNI5) has been identified control presence by binding promoter Pcps4A-J. Overexpression gene cyaA content 4.5- 2.2-fold, respectively. Furthermore, yogurt produced...
Abstract Aims The main purpose of this study was to the therapeutical effect oroxylin A glucuronide (OAG) on methicillin-resistant Staphylococcus aureus (MRSA). Methods and results By substrate peptide reaction-based fluorescence resonance energy transfer (FRET) screening, we identified that OAG an efficient inhibitor Sortase (SrtA) with IC50 45.61 μg mL−1, achieved efficacy in treatment (S. aureus) infections. We further demonstrated inhibited adhesion S. fibrinogen, surface protein...
The aim of the present study was to ivnestigate chemical constituents Chinese medicine Pi Han Yao (Gueldenstaedtia delavayi Franch) decoction. Following this, quantitative determination formononetin and maackiain content in established. were isolated by column chromatography their structures elucidated analysis spectrometric data evidence. High‑performance liquid (HPLC) used for Yao. Seven flavanones from Five as 1, 7,2'-dihydroxy-4'‑methoxy-isoflavanol; 2, maackiain; 3,...
Abstract Post-myocardial infarction heart failure (HF) is a major public health concern. Previous studies have reported the critical role of immune response in HF pathogenesis. However, limited predictive immune-associated biomarkers for HF. So we attempted to identify potential immune-related indicators early diagnosis and therapy guidance. This study identified two hub genes (IRHGs), namely CXCR5 FOS , using bioinformatic approaches. The expression levels their ability predict long-term...
Purpose: This study aimed to investigate the relationship between gut microbiota (GM) and serum metabolism using antineoplastic Fufangchangtai (FFCT) as model prescription in treatment of colorectal cancer (CRC). Methods: Tumor-bearing mice normal were administered different doses FFCT. The tumor volume tumor-bearing was observed. levels CD4 + CD8 T cells blood, spleen, determined a flow cytometer. bacterial stool samples from metabolomics FFCT-treated fecal transplantation detected 16s RNA...
Intestinal inflammation and compromised barrier function are critical factors in the pathogenesis of gastrointestinal disorders. This study aimed to investigate role miR-192-5p modulating intestinal epithelial (IEB) integrity its association with autophagy. A DSS-induced colitis model was used assess effects on inflammation. In vitro experiments involved cell culture transient transfection techniques. Various assays, including dual-luciferase reporter gene quantitative real-time PCR, Western...