A5021433972- Cloud Computing and Resource Management
- Advanced Data Storage Technologies
- Mobile Agent-Based Network Management
- Distributed and Parallel Computing Systems
- Blockchain Technology Applications and Security
- Microbial Natural Products and Biosynthesis
- Data Mining Algorithms and Applications
- Natural product bioactivities and synthesis
- Data Management and Algorithms
- Protein Structure and Dynamics
- Distributed systems and fault tolerance
- Macrophage Migration Inhibitory Factor
- Technology and Security Systems
- Advanced Database Systems and Queries
- Embedded Systems and FPGA Design
- Mitochondrial Function and Pathology
- RNA regulation and disease
- RNA Research and Splicing
- Electron Spin Resonance Studies
- Service-Oriented Architecture and Web Services
- Steroid Chemistry and Biochemistry
- Receptor Mechanisms and Signaling
- Drug Transport and Resistance Mechanisms
- Pluripotent Stem Cells Research
- Plant biochemistry and biosynthesis
State Key Laboratory of Microbial Technology
2021-2025
Shandong University
2021-2025
Sichuan Normal University
2020
University of California, Irvine
2011-2012
University of Electronic Science and Technology of China
2007-2011
The aryl hydrocarbon receptor (AHR) possesses an extraordinary capacity to sense and respond a wide range of small-molecule ligands, ranging from polycyclic aromatic hydrocarbons endogenous compounds. Upon ligand binding, AHR translocates the cytoplasm nucleus, forming transcriptionally active complex with nuclear translocator (ARNT), for DNA binding initiation gene expression programs that include cellular detoxification pathways immune responses. Here, we examine molecular mechanisms...
Blood–brain barrier (BBB) damage after ischemia significantly influences stroke outcome. Compound LFHP-1c was previously discovered with neuroprotective role in model, but its mechanism of action on protection BBB disruption remains unknown. Here, we show that LFHP-1c, as a direct PGAM5 inhibitor, prevented transient middle cerebral artery occlusion (tMCAO) rats. Mechanistically, binding endothelial not only inhibited the phosphatase activity, also reduced interaction NRF2, which facilitated...
The innate immune sensor NLRP3 inflammasome overactivation is involved in the pathogenesis of ulcerative colitis. PGAM5 a mitochondrial phosphatase activation macrophages. However, role colitis and mechanisms underlying regulating activity remain unknown. Here, we show that deficiency ameliorates dextran sodium sulfate (DSS)-induced mice via suppressing activation. By combining APEX2-based proximity labeling focused on with quantitative proteomics, identify NEK7 as new binding partner to...
Navigational Programming (NavP) is a new approach to distributed programming based on migrating threads. Under this model of computation, an application structured as collection processes, which can migrate autonomously through application-specific network nodes. has been demonstrated have significant advantages over other paradigms including message passing (MP) and shared memory (DSM), for general-purpose computing. JaMes superset Java, in that it provides methods implement the...
We present a new methodology for developing parallel distributed programs in series of incremental steps. The takes advantage threads that are able to migrate through the network and thus follow data. This allows data be partitioned first, which guarantees elements used together computation collocated on same node. Next, loops code tiled minimize migration among nodes. After deciding location at each loop is execute, necessary remote access statements inserted make executable. process...
Abstract With the development of cloud computing, task scheduling has been an important problem in computing. We should consider not only performance resources, but also reliability resources and users for resource allocation scheduling. proposed a trusted model based on game theory to evaluate scores participants. Simulation results show tend send feedback information agents order increase their scores. Also score is factor affect decision allocation. Results our improved utilization load balance.