A5101545370- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Enzyme Production and Characterization
- Helicobacter pylori-related gastroenterology studies
- Galectins and Cancer Biology
- Antibiotic Resistance in Bacteria
- Genomics and Phylogenetic Studies
- Bacterial Identification and Susceptibility Testing
- Microbial Metabolism and Applications
- Antimicrobial Peptides and Activities
- Microbial Community Ecology and Physiology
- Ammonia Synthesis and Nitrogen Reduction
- Veterinary medicine and infectious diseases
- Neural dynamics and brain function
- Advanced Photocatalysis Techniques
- Neuroscience and Neural Engineering
- Protease and Inhibitor Mechanisms
- Constructed Wetlands for Wastewater Treatment
- Biochemical and Structural Characterization
- Protein Hydrolysis and Bioactive Peptides
- Advanced Memory and Neural Computing
- Meat and Animal Product Quality
- Bacteriophages and microbial interactions
- Mycobacterium research and diagnosis
- Antimicrobial agents and applications
Inner Mongolia University
2023-2025
Tongji University
2021-2024
Binzhou University
2015-2024
Binzhou Medical University
2015-2024
Shanghai Pulmonary Hospital
2021-2024
Qingdao University of Science and Technology
2022-2024
Suzhou University of Science and Technology
2024
City University of Hong Kong
2023-2024
Wenzhou Medical University
2024
First Affiliated Hospital of Wenzhou Medical University
2024
Abstract Predator-prey interactions play important roles in the cycling of marine organic matter. Here we show that a Gram-negative bacterium isolated from sediments ( Pseudoalteromonas sp. strain CF6-2) can kill Gram-positive bacteria diverse peptidoglycan (PG) chemotypes by secreting metalloprotease pseudoalterin. Secretion enzyme requires Type II secretion system. Pseudoalterin binds to glycan strands Gram positive bacterial PG and degrades peptide chains, leading cell death. The released...
The aim of this study was to investigate the genomic epidemiology MRSA in China identify predominant lineages and their associated phenotypic characteristics. In study, we conducted whole-genome sequencing on 565 isolates from 7 provinces municipalities between 2014 2020. were subjected MLST, spa typing, SCCmec analysis virulence determinants antimicrobial susceptibility testing. Among tested, clonal complex (CC) 59 (31.2%), CC5 (23.4%) CC8 (13.63%) major lineages, structure dominated by...
Background: Since December 2019, SARS-CoV-2 has continued to spread rapidly around the world. The effective drugs may provide a long-term strategy combat this virus. main protease (Mpro) and papain-like (PLpro) are two important targets for inhibition of virus replication proliferation. Materials & methods: In study, deep reinforcement learning, covalent docking molecular dynamics simulations were used identify novel compounds that have potential inhibit both Mpro PLpro. Results conclusion:...
The emergence of antibiotic-resistant and biofilm-producing
ABSTRACT The emergence of Klebsiella pneumoniae carbapenemase-2 (KPC-2) and New Delhi metallo-β-lactamase (NDM)-coproducing hypervirulent carbapenem-resistant (KPC-2-NDM-hv-CRKP) poses a certain threat to public health. Currently, only few sporadic reports such double-positive hv-CRKPs were available. In this study, we isolated two KPC-2-NDM-5-hv-CRKPs from elderly patients with serious underlying diseases poor prognoses. We found both FK3122 FK3127 typical multidrug-resistant (MDR)...
EEG microstates have been widely adopted to understand the complex and dynamic-changing process in dynamic brain systems, but how are temporally modulated by emotion dynamics is still unclear. An investigation of under video-evoking modulation would provide a novel insight into understanding temporal functional networks.In present study, we postulate that emotional states dynamically modulate microstate patterns, perform an in-depth between video-watching task. By mapping from...
Previous studies have shown that the increased prevalent ST764 clone in China, Japan, and other Asian areas. However, knowledge of genetic features virulence characteristics methicillin-resistant Staphylococcus aureus (MRSA) China is still limited. In this study, we identified 52 ST764-SCCmec type II isolates collected from five cities between 2014 2021. Whole genome sequencing showed most common staphylococcal protein A (spa) types were t002 (55.78%) t1084 (40.38%). Virulence assays...
Intracranial implants for diagnosis and treatment of brain diseases have been developed over the past few decades. However, platform conventional implantable devices still relies on invasive probes bulky sensors in conjunction with large-area craniotomy provides only limited biometric information. Here, an multi-modal sensor array that can be injected through a small hole skull inherently spread out conformal contact cortical surface is reported. The injectable array, composed graphene...
In recent years, the hypervirulent and carbapenem-resistant Klebsiella pneumoniae has been increasingly reported worldwide. The objective of this study was to compare antibiotic resistance virulence profiles K.pneumoniae (CR-hvKP) (hv-CRKP) identify prevailing strain in clinical settings.
Abstract Electrochemical nitrate reduction to ammonia (eNO 3 RR) in neutral conditions is an effective and sustainable method for production while treating pollution. Nevertheless, it still faces a great challenge due the complicated multiple proton‐coupled‐electron process eNO RR. Herein, efficient heterostructure electrocatalyst Cu‐Cu 2 O/Ni P has been successfully fabricated electrosynthesis from reduction. exhibits outstanding RR performance with Faradaic efficiency (FE) as high 96.4%...
Collagens are the most abundant proteins in marine animals and their degradation is important for recycling of nitrogen. However, it rather unclear how collagens degraded because few collagenolytic proteases studied detail. Deseasins a new type multidomain subtilases. Here, activity deseasin MCP-01, example deseasins, was studied. MCP-01 had broad substrate specificity to various from terrestrial animals. It completely decomposed insoluble collagen into soluble peptides amino acids, more...
Abstract Pseudolysin is the most abundant protease secreted by Pseudomonas aeruginosa and major extracellular virulence factor of this opportunistic human pathogen. destroys tissues solubilizing elastin. However, mechanisms which pseudolysin binds to degrades elastin remain elusive. In study, we investigated mechanism action on binding degradation biochemical assay, microscopy site-directed mutagenesis. bound bovine fibers preferred attack peptide bonds with hydrophobic residues at P1 P1’...
The rapid emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) and the comparatively limited development new antibiotics pose a major threat to public health. Aminoglycosides are important options that can lower mortality rate effectively in combination therapy with β-lactam agents. However, this study, we observed two multidrug-resistant (MDR) K. named 1632 1864 exhibited high-level resistance both carbapenems aminoglycosides. Through whole-genome sequencing (WGS), unusual...
Marine xylanases are rather less studied compared to terrestrial xylanases. In this study, a new xylanase gene, xynB, was cloned from the marine bacterium, Glaciecola mesophila KMM241, and expressed in Escherichia coli. xynB encodes multi-domain XynB of glycoside hydrolase (GH) family 8. The recombinant comprises an N-terminal domain (NTD) with unknown function catalytic domain, which is structurally novel among characterized GH has highest identity (38%) rXyn8 showed maximal activity at pH...
Methicillin-resistant Staphylococcus aureus (MRSA) ST8 strains have spread worldwide, causing outbreaks in various regions. However, this clone has only been sporadically reported China. Consequently, detailed information regarding the phylogeny and potential virulence of S. China remains unknown. In study, we characterized six collected from three tertiary hospitals China, including MRSA (MR50, MR526, MR254) MSSA (H78, H849 H863). Whole genome sequencing phylogenetic analysis showed that...
The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) strains and restricted therapeutic options pose a global threat to public health. Aminoglycosides are wise choice, which can effectively reduce the mortality rate when combined with β-lactam drugs. However, in this study, we identified ST15-KL112 CRKP FK3006 not only exhibited resistance carbapenems, but also high level aminoglycosides. In addition multidrug resistant phenotype, owned typical pathogenic characteristic,...
ST22 MRSA (methicillin-resistant Staphylococcus aureus) strains are only sporadically reported in China. Through the phylogenetic reconstruction of 30 from China and 480 global sources, we found that can be divided into three clades (I, II, III). The were primarily clade II (IIb IIc) also III, indicating ST22-MRSA clones have different origins. subclade IIb (SCCmec Vb-t309) may evolve native MSSA clone, while IIc spread other countries. Subclade (SCCmecIVa-t309) exhibited particularly strong...
The pathogenicity of Staphylococcus epidermidis is largely attributed to its exceptional ability form biofilms. Here, we report that mupirocin, an antimicrobial agent widely used for staphylococcal decolonization and anti-infection, strongly stimulates the biofilm formation S. epidermidis. Although polysaccharide intercellular adhesin (PIA) production was unaffected, mupirocin significantly facilitated extracellular DNA (eDNA) release by accelerating autolysis, thereby positively triggering...
SHP1 has been documented as a tumor suppressor and it was thought to play an antagonistic role in the pathogenesis of Helicobacter pylori infection. In this study, exact mechanism action studied.