A5100382954- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Advanced biosensing and bioanalysis techniques
- Metal-Organic Frameworks: Synthesis and Applications
- Nanocluster Synthesis and Applications
- Metamaterials and Metasurfaces Applications
- Advanced Nanomaterials in Catalysis
- Advanced Antenna and Metasurface Technologies
- Magnetism in coordination complexes
- Carbon and Quantum Dots Applications
- Material Dynamics and Properties
- Luminescence and Fluorescent Materials
- Covalent Organic Framework Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Lanthanide and Transition Metal Complexes
- Electromagnetic wave absorption materials
- Metabolomics and Mass Spectrometry Studies
- Biosensors and Analytical Detection
- Toxoplasma gondii Research Studies
- Graphene and Nanomaterials Applications
- Perovskite Materials and Applications
- Theoretical and Computational Physics
- Protein Interaction Studies and Fluorescence Analysis
- Nanoplatforms for cancer theranostics
Peking University People's Hospital
2025
Peking University
2013-2025
Second Hospital of Shanxi Medical University
2025
Shanxi Medical University
2025
Dalian Institute of Chemical Physics
2019-2025
Jiangxi Normal University
2024-2025
Weichai Power (China)
2025
University of Chinese Academy of Sciences
2017-2025
Shanghai Normal University
2023-2025
Gansu University of Traditional Chinese Medicine
2024-2025
Three isomorphous compounds M(CHOO)3[NH2(CH3)2] (M = Mn(1·Mn), Co(2·Co), Ni(3·Ni)) have been synthesized in solvothermal conditions. Single-crystal X-ray diffraction shows that they are all crystallized the trigonal space group R 3̄c with small differences lattice parameters. Bridged by three-atom single-bridge CHOO-, M ions form a three-dimensional distorted perovskite-like structure dimethylamine (DMA) cations located cages of network. Based on magnetic data, these three 3D weak...
When nanoparticles are exposed to a physiological environment, "protein corona" is formed that greatly determines their biological fate. Adsorption of proteins could be influenced by chiral surfaces nanoparticles; however, very few quantitative studies available on the interaction protein with surface nanoparticles, and underlying mechanism remains largely unresolved. We have developed strategy quantitatively analyze adsorption conformational features transferrin gold functionalized d, l,...
Toehold-mediated strand displacement reaction (SDR) is first introduced to develop a simple quartz crystal microbalance (QCM) biosensor without an enzyme or label at normal temperature for highly selective and sensitive detection of single-nucleotide polymorphism (SNP) in the p53 tumor suppressor gene. A hairpin capture probe with external toehold designed immobilized on gold electrode surface QCM. successive SDR initiated by target sequence hybridization domain ends unfolding probe....
The nanoparticle (nano)–cell membrane interface is one of the most important interactions determining fate nanoparticles (NPs), which can stimulate a series biological events, allowing theranostic and other biomedical applications. So far, there remains lack knowledge about mechanisms governing nanoparticle−cell interface, especially impact ligand exchange, in molecules on nanosurface become replaced with components cell membrane, resulting unique interfacial phenomena. Herein, we describe...
Chiral properties of nanoscale materials are importance as they dominate interactions with proteins in physiological environments; however, have rarely been investigated. In this study, a systematic investigation is conducted for the adsorption behaviors bovine serum albumin (BSA) onto chiral surfaces gold nanoparticles (AuNPs), involving multiple techniques and molecular dynamic (MD) simulation. The BSA both L- D-chiral AuNPs shows discernible differences thermodynamics, orientation,...
Toxoplasma gondii is an opportunistic pathogen widely distributed within the world, poses a huge threat to human health, and causes significant economic losses livestock industry. Herein, we developed portable one-pot detection of T. by combining recombinase polymerase amplification (RPA) clustered regularly interspaced short palindromic repeats (CRISPR)/Cas12a system. A glass microfiber filter device used for first step can efficiently extract from low-concentration samples. The lyophilized...
Escherichia coli continues to be the predominant Gram-negative pathogen causing neonatal meningitis worldwide. Inflammatory mediators have been implicated in pathogenesis of and are key therapeutic targets. The role interleukin-22 (IL-22) various diseases is diverse, with both protective pathogenic effects. However, little understood about mechanisms underlying damaging effects IL-22 on blood–brain barrier (BBB) E. meningitis. We observed that meningitic infection induced expression serum...
Abstract Bacterial meningitis remains a leading cause of infection-related mortality worldwide. Although Escherichia coli ( E. ) is the most common etiology neonatal meningitis, underlying mechanisms governing bacterial blood-brain barrier (BBB) disruption during infection remain elusive. We observed that human brain microvascular endothelial cells with meningitic triggers activation early growth response 1 (Egr-1), host transcriptional activator. Through integrated chromatin...
Glycans play vital roles in nearly all life processes of multicellular organisms, and understanding these activities is inseparable from elucidating the biological significance glycans. However, glycan research has lagged behind that DNA protein due to challenges posed by structural heterogeneity isomerism (i.e., structures with equal molecular weights) lack high-efficiency analysis techniques. Nanopore technology emerged as a sensitive single-molecule biosensor, shining light on analysis....
Background: Outbreaks of human infection with a new avian influenza A H7N9 virus occurred in China the spring 2013. Control and prevention infectious disease outbreak can be strongly affected by public reaction social impact through Internet media. Objective: This study aimed to investigate potential roles surveillance control outbreaks. Methods: Official data for outbreaks were collected via National Health Family Planning Committee website from March 31 April 24, We obtained daily posted...
A series of isostructural lanthanide coordination polymers (Ln-CPs) formulated as [Ln(tcptpy)(H2O)2·2H2O]n {Ln3+ = Sm3+ (1), Eu3+ (2), Gd3+ (3), Tb3+ (4), Dy3+ (5); H3tcptpy 4-(2,4,6-tricarboxylphenyl)-4,2':6',4''-terpyridine} has been afforded and characterized systematically. Their structures were established by single-crystal X-ray diffraction. All the complexes feature two dimensional (2D) layers with (4,4)-connected topology. By virtue frameworks, a family binary co-doped Ln-CPs...
We investigate the fast β- and Johari–Goldstein (JG) β-relaxation processes, along with elastic scattering response of glass-forming (GF) liquids boson peak, in a simulated Al–Sm GF material exhibiting fragile–strong (FS) transition. These dynamical processes are universal “ordinary” fluids collectively describe their “fast dynamics,” we find these relaxation also arise liquid FS String-like particle motion, having both an irreversible reversible nature (stringlets) component, occurs...