A5032457247- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Cytomegalovirus and herpesvirus research
- Polyomavirus and related diseases
- T-cell and B-cell Immunology
- Histone Deacetylase Inhibitors Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neutropenia and Cancer Infections
- CAR-T cell therapy research
- Transplantation: Methods and Outcomes
- Immunotherapy and Immune Responses
- Antifungal resistance and susceptibility
- Lymphoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Viral-associated cancers and disorders
- Fungal Infections and Studies
- Multiple Myeloma Research and Treatments
- Eosinophilic Disorders and Syndromes
- Particle physics theoretical and experimental studies
- Hemoglobinopathies and Related Disorders
Southern Medical University
2016-2025
Nanfang Hospital
2016-2025
Key Laboratory of Guangdong Province
2019-2025
Beijing Planetarium
2024
Southwest Jiaotong University
2024
University of Chinese Academy of Sciences
2020-2024
Sun Yat-sen University
1997-2024
Kailuan General Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Jiangsu Provincial Center for Disease Control and Prevention
2024
The information of protein targets and small molecule has been highly valued by biomedical pharmaceutical research. Several target databases are available online for FDA-approved drugs as well the promising precursors that have largely facilitated mechanistic study subsequent research drug discovery. However, those related resources regarding to herbal active ingredients, although being unusually a precious resource new development, is rarely found. In this article, comprehensive fully...
Despite the high cure rate of T cell acute lymphoblastic leukemia (T-ALL), drug resistance to chemotherapy remains a significant clinical problem. Bone marrow mesenchymal stem cells (MSCs) protect leukemic from chemotherapy, but underlying mechanisms are poorly understood. In this study, we aimed uncover mechanism MSC-induced chemoresistance in T-ALL cells, thus providing promising therapy target.Cell viability was determined using assay kit CCK-8. The mitochondrial ROS levels were detected...
Abstract The consensus recommendations in 2018 from Chinese Society of Hematology (CSH) on indications, conditioning regimens and donor selection for allogeneic hematopoietic stem cell transplantation (allo-HSCT) facilitated the standardization clinical practices allo-HSCT China progressive integration with world. There have been new developments since initial publication. To integrate recent further improve consensus, a panel experts CSH recently updated recommendations, which are...
The lack of a general clinic-relevant model for human cancer is major impediment to the acceleration novel therapeutic approaches clinical use. We propose establish and characterize primary hepatocellular carcinoma (HCC) xenografts that can be used evaluate cytotoxicity adoptive chimeric antigen receptor (CAR) T cells accelerate translation CAR in HCC. Primary HCCs were xenografts. morphology, immunological markers, gene expression characteristics detected compared those corresponding...
Haploidentical donor (HID) hematopoietic stem cell transplantation (HSCT) is an alternative treatment method for severe aplastic anemia (SAA) patients lacking suitable identical donors and those who are refractory to immunosuppressive therapy (IST). The current study evaluated the feasibility of upfront haploidentical HSCT in SAA patients. We conducted a multicenter based on registry database. One hundred fifty-eight underwent between June 2012 September 2015 were enrolled. Eighty-nine had...
Abstract Background Relapsed or refractory acute myeloid leukemia (R/R AML) has a dismal prognosis. The aim of this study was to investigate the activity and tolerability venetoclax combined with azacitidine plus homoharringtonine (VAH) regimen for R/R AML. Methods This phase 2 trial done at ten hospitals in China. Eligible patients were AML (aged 18–65 years) an Eastern Cooperative Oncology Group performance status 0–2. Patients received (100 mg on day 1, 200 2, 400 days 3–14) (75 mg/m 1–7)...
Highlights•MSCs ameliorate the thymic function of aGVHD patients.•MSCs repaire damaged thymus, thus incidence cGVHD decreases.•MSCs have similar efficacy to aGVHD, but our strategy differs with other literature.AbstractRefractory acute graft-versus-host disease (aGVHD) is a major cause death after allogeneic hematopoietic stem cell transplantation. This study evaluated immunomodulation effects mesenchymal stromal cells (MSCs) from bone marrow third-party donor for refractory aGVHD....
Abstract Purpose: Although matched-sibling donor (MSD) hematopoietic stem-cell transplantation (HSCT) has an established role in the management of adults with acute lymphoblastic leukemia (ALL) first complete remission (CR1), effect haploidentical (HID) HSCT as post-remission treatment for this portion patients is not defined. Experimental Design: Transplantation outcomes from HIDs or MSDs were compared a disease-specific, biologically phase III randomized, multicenter study. Between July...
Summary We conducted a prospective, multicentre study to confirm the feasibility of haplo‐identical transplantation in treatment severe aplastic anaemia ( SAA ) as salvage therapy, by analysing outcomes 101 patients who received between June 2012 and October 2015. All cases surviving for more than 28 d achieved donor myeloid engraftment. The median time engraftment was 12 (range, 9–25) days 15 7–101) platelets, with cumulative platelet incidence 94·1 ± 0·1%. With follow‐up 18·3 (3·0–43·6)...
Low-dose post-transplant cyclophosphamide (PTCy) in conjunction with anti-thymocyte globulin (ATG) appears as a potentially effective graft-versus-host disease (GVHD) prevention strategy haploidentical hematopoietic cell transplant (haplo-HCT). Our study aims to assess the efficacy of this regimen.We extended our prospective patients treated low-dose PTCy (14.5 mg/kg on days 3 and 4) ATG/granulocyte colony-stimulating factor (G-CSF)-based regimen compared results contemporary cohort without...
Altered glucose metabolism has been described as a cause of chemoresistance in multiple tumor types. The present study aimed to identify the expression profile drug-resistant acute myeloid leukemia (AML) cells and provide potential strategies for treatment AML. Bone marrow serum samples were obtained from patients with AML that newly diagnosed or had relapsed. messenger RNA hypoxia inducible factor (HIF)-1α, transporter (GLUT)1, hexokinase-II was measured by quantitative polymerase chain...
The role of antithymocyte globulin (ATG) in preventing acute graft-versus-host disease (aGVHD) after HLA-matched sibling donor transplantation (MSDT) is still controversial.We performed a prospective, multicenter, open-label, randomized controlled trial (RCT) across 23 centers China. Patients ages 40-60 years with standard-risk hematologic malignancies an were randomly assigned to ATG group (4.5 mg/kg thymoglobulin plus cyclosporine [CsA], methotrexate [MTX], and mycophenolate mofetil [MMF])...
Abstract Between 2008 and 2019, 58,914 hematopoietic stem cell transplantations (HSCTs) were reported to the Chinese Blood Marrow Transplantation Registry Group (CBMTRG) throughout China. In this report, we focus on 2019 data describe current trends in HSCT There was continued growth transplant activity China, with a rapid increase haploidentical HSCT. total of 12,323 cases from 149 teams, 78% (9597 cases) allogeneic HSCTs. Haploidentical donor (HID) accounted for 60% (5771 The most common...