A5100723753- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- Acute Lymphoblastic Leukemia research
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- Diet, Metabolism, and Disease
- Acute Myeloid Leukemia Research
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Polyomavirus and related diseases
- Childhood Cancer Survivors' Quality of Life
- Cardiovascular Disease and Adiposity
- Neuroblastoma Research and Treatments
- Diabetes and associated disorders
- Pediatric health and respiratory diseases
- Regulation of Appetite and Obesity
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Blood groups and transfusion
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Chronic Lymphocytic Leukemia Research
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Management and Research
- Effects and risks of endocrine disrupting chemicals
- Erythrocyte Function and Pathophysiology
Sun Yat-sen University
2016-2025
Sun Yat-sen Memorial Hospital
2016-2025
Hubei University of Medicine
2025
Taihe Hospital
2025
Children's Hospital of Zhejiang University
2015-2024
Zhejiang University
2008-2024
Institute of Hematology & Blood Diseases Hospital
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Shenzhen Academy of Inspection and Quarantine
2021-2024
China-Japan Friendship Hospital
2023-2024
Previous studies in rodent models have shown that early-life exposure to bisphenol A (BPA) reprograms the prostate and enhances its susceptibility hormonal carcinogenesis with aging. To determine whether human is similarly sensitive BPA, current study used epithelial stem-like cells cultured from prostates of young, disease-free donors. Similar estradiol-17β (E2), BPA increased stem-progenitor cell self-renewal expression stem-related genes a dose-dependent manner. Further, 10 nM E2...
Highlights•MSCs ameliorate the thymic function of aGVHD patients.•MSCs repaire damaged thymus, thus incidence cGVHD decreases.•MSCs have similar efficacy to aGVHD, but our strategy differs with other literature.AbstractRefractory acute graft-versus-host disease (aGVHD) is a major cause death after allogeneic hematopoietic stem cell transplantation. This study evaluated immunomodulation effects mesenchymal stromal cells (MSCs) from bone marrow third-party donor for refractory aGVHD....
High-grade myopia (HM) is highly heritable, and has a high prevalence in the Han Chinese population. We carried out genome-wide association study involving 102 HM cases suffering from retinal degeneration, 335 controls who were free fundus diseases. Significant single-nucleotide polymorphisms replicated two follow-up studies: stage I involved 2628 independent 9485 controls, II further 263 586 HM-free controls. The results combined meta-analysis. Cases drawn A locus an intergenic region at...
Phosphorylation of heptahelical receptors is thought to regulate G protein signaling, receptor endocytosis, and non-canonical signaling via recruitment β-arrestins. We investigated chemokine functionality under phosphorylation-deficient β-arrestin-deficient conditions by studying interneuron migration in the embryonic cortex. This process depends on CXCL12, CXCR4, atypical CXCL12 ACKR3. found that phosphorylation was crucial, whereas β-arrestins were dispensable for ACKR3-mediated control...
Signal transducer and activator of transcription 3 (STAT3) is a central cytoplasmic factor. Abnormal activation STAT3 plays critical role in oncogenesis has been found frequently wide variety human tumors including pancreatic cancer. In this study, we elucidated the significance signaling pathway on metastatic potentials We that phosphorylated (p‐STAT3) protein levels were significantly higher highly SW1990 cells compared to poorly CaPan‐2 cells, which expressed weak protein. Furthermore,...
Aims Transducer and activator of transcription-3 (STAT3) plays an important role in tumor cell invasion metastasis. The aim the present study was to investigate effects STAT3 knockdown nude mouse xenografts pancreatic cancer cells underlying gene expression. Methods A shRNA lentiviral vector constructed infected into SW1990 cells. qRT-PCR western immunoblot were performed detect Nude xenograft assays used assess changes phenotypes these stable vivo. HE staining utilized evaluate...
Missense variants in KCNJ11 and ABCC8, which encode the KIR6.2 SUR1 subunits of β-cell KATP channel, have previously been implicated type 2 diabetes, neonatal hyperinsulinemic hypoglycemia infancy (HHI). To determine whether variation these genes affects risk for diabetes or increased birth weight as a consequence fetal hyperinsulinemia Pima Indians, missense common noncoding were analyzed individuals living Gila River Indian Community. A R1420H variant (ABCC8) was identified 3.3% population...
Neuroblastoma (NB), the most common extracranial solid tumor in childhood, significantly contributes to cancer-related mortality, presenting a dearth of efficacious treatment strategies. Previously, our studies have substantiated potent cytotoxicity arsenic trioxide (ATO) against NB cells, however, specific underlying mechanism remains elusive. Here, we first identified ATO as novel GPX4 inhibitor, which could trigger ferroptosis cells. In vitro, inhibited proliferation and migration ability...
Context: Chemerin has been implicated to be correlated with inflammation.Objective: This study aims determine the association of chemerin levels in serum and synovial fluid (SF) disease severity patients knee Osteoarthritis (OA).Methods: 124 OA 76 healthy controls were enrolled this study.Results: significant higher regard paired SF. levles SF evaluated by KL grading criteria.Conclusion: may involved pathophysiology development progression OA.
Objective: We aimed to assess the role of adipose tissue distribution in cardiometabolic risk (in particular insulin sensitivity) a population children and adolescents with obesity. Methods: In this cross-sectional study, participants were 479 obesity (322 boys 157 girls) aged 3 18 years attending Children's Hospital at Zhejiang University School Medicine (Hangzhou, China). Clinical assessments included anthropometry, body composition (DXA scans), carotid artery ultrasounds, OGTT. Insulin...
<h3>Importance</h3> Obesity is a public health challenge in China, but the geographical profiles of overweight and obesity among Chinese children are limited. <h3>Objective</h3> To examine regional disparities prevalence heterogeneous population adolescents to provide more accurate profile China. <h3>Design, Setting, Participants</h3> The Prevalence Risk Factors for Diabetes Youth (PRODY) study was cross-sectional survey conducted from January 1, 2017, December 31, 2019, 201 098 aged 3 18...
Trophoblast dysfunction during pregnancy time is majorly involved to lead pathogenesis of preeclampsia. In the present investigation, facile nanoformulation by Zein protein particles functionalized with hydroxypropyl-beta-cyclodextrin (β-CD) and co-encapsulated curcumin eugenol compounds (Cu/Eu@H-β-CD-ZNPs) developed achieve enhanced therapeutic potential in treatment To investigate positive trophoblast function, cells were treated observed for vitro cell proliferation, invasion migration...
Diamond-Blackfan anemia (DBA) is a congenital erythroid aplasia associated with physical anomalies and predisposition to cancer. It categorized as ribosomopathy related heterozygous allelic variations in ribosomal protein (RP) genes. Pierre Robin sequence (PRS) rare etiologically heterogeneous condition, defined by the clinical triad of micrognathia, glossoptosis, cleft palate. We present 5-year-and-2-month-old Chinese boy diagnosed DBA combined RPS. He was born palate, airway obstruction,...
Objective: To evaluate the effectiveness and safety of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children with stage 4/M neuroblastoma (NB). Methods: This study was a prospective, single-arm, multicenter clinical trial conducted by Sun Yat-sen Memorial Hospital, Children's Hospital Nanjing Medical University, Zhejiang University School Medicine, First Affiliated Guangxi Xinhua to Shanghai Jiao Tong Medicine. From March 1, 2019 August 31, 2023, 25 confirmed NB received...
To investigate carotid intima-media thickness (IMT) and serum endothelial marker levels in obese Chinese children.Observational descriptive study.Hangzhou, China.A total 131 children, including 29 with at least 2 components of metabolic syndrome (MS) (MS group), 102 less than MS (obese 31 nonobese children (control group) were enrolled.Intima-media thickness, von Willebrand factor (vWF) level, thrombomodulin level.Compared the control group, group had greater IMT higher vWF level (P < .05...
The suspected endocrine disruptor bisphenol A (BPA) is associated with the manufacture, distribution, and use of epoxy resins polycarbonate plastics; thus, studies this compound have focused primarily on urban areas in developed countries. This small study investigating urinary BPA 109 people was conducted United States, Jamaica, rural Ghana. Additionally, local drinking surface water samples were collected analyzed from near participants. Levels both urine comparable among all three sites....
Sewage treatment plant (STP) effluent has been used as ecological supplementary water in dry and polluted urban rivers. However, more consideration should be given to the impact of STP on quality environment. In this paper, a typical tributary river Dianchi was selected study plankton communities. Using paired-sample t-test, factor analysis canonical correspondence analysis, changes quality, communities their relationships were analyzed. The results showed that decreased concentrations...
The long-term overall survival of children with T-cell acute lymphoblastic leukemia (T-ALL) is limited to approximately 80-85% because a high incidence relapse after achieving remission intensive chemotherapy and hematopoietic stem cell transplantation (HSCT). Novel treatment strategies inducing are needed improve the outcome. Histone deacetylase inhibitors (HDACis) have been reported be effective in series T-ALL cases. Preclinical studies suggested that cells sensitive Chidamide, which...
Mucopolysaccharidoses (MPSs) are caused by a deficiency in the enzymes needed to degrade glycosaminoglycans (GAGs) lysosome. The storage of GAGs leads involvement several systems and even death patient. In recent years, an increasing number therapies have increased treatment options available patients. Early is beneficial improving prognosis, but children with MPSs often delayed their diagnosis. Therefore, there urgent need develop method for early screening diagnosis disease. Tandem mass...
Glucokinase (GCK) plays a role in glucose metabolism and glucose-stimulated insulin secretion. Rare mutations GCK cause MODY. We investigated whether common variation (minor allele frequency ≥0.01) is associated with metabolic traits type 2 diabetes.Four exonic single-nucleotide polymorphisms (SNPs) three SNPs predicted to loss of promoter function were identified whole-genome sequence data from 234 Pima Indians. These seven tag rs4607517, diabetes variant established other studies, analysed...
Six rare functional coding mutations were previously identified in melanocortin 4 receptor (MC4R) 6,760 American Indians. Individuals heterozygous for one of these become obese while young. We now investigate whether common non-coding variation near MC4R also contributes to obesity. Fifty-six tag single-nucleotide polymorphisms (SNPs) genotyped 3,229 full-heritage Pima Indians, and nine SNPs which showed evidence association additional 3,852 mixed-heritage Associations with maximum body mass...