A5081757882- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Reactions
- Asymmetric Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- Sulfur-Based Synthesis Techniques
- Synthetic Organic Chemistry Methods
- Surface Chemistry and Catalysis
- Obesity, Physical Activity, Diet
- Dam Engineering and Safety
- Catalysis for Biomass Conversion
- Catalytic C–H Functionalization Methods
- Advanced Synthetic Organic Chemistry
- Carbon dioxide utilization in catalysis
- Luminescence Properties of Advanced Materials
- Nanoparticle-Based Drug Delivery
- Child Nutrition and Water Access
- Microbial Natural Products and Biosynthesis
- Health and Well-being Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Soil, Finite Element Methods
- Advanced Photocatalysis Techniques
China Three Gorges University
2011-2025
Shanghai Institute of Organic Chemistry
2024
Chinese Academy of Sciences
1998-2024
Hangzhou Dianzi University
2024
Shandong Jianzhu University
2023
Shanxi Agricultural University
2023
Beijing Normal University - Hong Kong Baptist University United International College
2023
Beijing Normal University
2023
Wuhan Medical Center for Women and Children
2021-2022
Hangzhou Vocational and Technical College
2022
Abstract Background Global countries are suffering from a shortage of health professionals. Turnover intention is closely related to job satisfaction and burnout, making good use these relationships could alleviate the crisis. Our research aims examine mediating role in relationship between burnout turnover intention. Methods This was conducted Huangpi, China. The convenience sampling method self-administereded questionnaires were used. 1370 valid samples collected with 97.72% effective...
In the current global crisis of antibiotic resistance, delivery systems are emerging to combat resistant bacteria in a more efficient manner. Despite significant advances nanocarriers, many challenges like poor biocompatibility, premature drug release, suboptimal targeting infection sites and short blood circulation time still challenging. To achieve targeted enhance antibacterial activity, here we reported kind pH-responsive nanoparticles by simply self-assembly an amphiphilic poly(ethylene...
A P(NMe2)3-catalyzed [4 + 2] annulation of 2-amino-β-nitrostyrenes and β′-acetoxy allenoates followed by a Zn/AcOH-mediated reduction–hydroamination–isomerization has been developed.
In this work, we design mesoporous silica-coated Prussian blue nanocubes with PEGyltation to construct multifunctional PB@mSiO2–PEG nanocubes. The have good biocompatibility, excellent photothermal transformation capacity, in vivo magnetic resonance and photoacoustic imaging ability. After loading antitumor drug doxorubicin (DOX) the nanocubes, constructured PB@mSiO2–PEG/DOX nanoplatforms show an pH-responsive release character within 48 h, namely, ultralow cumulative amount of 3.1% at pH...
An Fe-catalyzed 2-deoxy glycosylation method was developed from 3,4-O-carbonate glycals directly at room temperature. This novel approach enabled facile access to alkyl and aryl glycosides in high yields with exclusive α-stereoselectivity, tolerating various alcohols, phenols, glycals. The synthetic utility advantage of this strategy have been demonstrated by the modification six natural products construction a tetrasaccharide.
A core-shell structured heterogeneous rhodium catalyst exhibited excellent catalytic activity and enantioselectivity in asymmetric transfer hydrogenation of aromatic ketones aqueous medium, which could be recovered easily used repetitively twelve times without affecting obviously its enantioselectivity.
Stereoselective construction of various O-glycosidic bonds was first achieved by different palladium sources using 3,4-O-carbonate galactal as the donor to reach yields up 95% under mild conditions. With Pd(II) catalyst coordination this glycal from β-face directed carbonate group, hard nucleophiles (aliphatic alcohols) gave β-glycosides and α-glycosides were obtained soft (phenols). In contrast, with Pd(0) coordinating due steric effect, both acceptors could only generate via...
An effective regiodivergent synthesis toward 1- and 3-thiosugars was achieved through palladium cobalt catalysis, respectively. β-1-Thiosugars were obtained from 3,4-O-carbonate-glycals various thiols catalyzed by Pd2(dba)3 in good yields with exclusive stereoselectivity chemoselectivity, while only (3S)-3-thiosugars generated via Co(BF4)2. Experiments DFT calculations supported the proposed mechanism that thiol moiety preferred to form a hydrogen bond C4-oxygen top-face Pd conditions but...
An open-air palladium-catalyzed O-glycosylation was developed using glycals and arylboronic acids with base additives at ambient conditions. The novel approach enabled facile access to various O-glycosides in high yields, exclusive 1,4-cis-stereoselectivity tolerating reactive hydroxyl/amino groups. Mechanistic studies indicated that chemo-/stereoselectivity arose from the coordination between palladium phenols generated situ by oxidizing acids, followed an intramolecular attack....
A novel phosphine-mediated α-umpolung/Wittig olefination/cyclization cascade process between o -aminobenzaldehydes and Morita–Baylis–Hillman (MBH) carbonates has been ingeniously developed for the facile synthesis of a broad range 2-vinylindolines.
Annulation reactions are recognized for their efficiency in constructing complex cyclic compounds with multiple substitutions, aligning well green chemistry principles. Herein, we report a transition metal-free, chemodiverse cycloaddition reaction...
Comprehensive Summary Vicinal all‐carbon quaternary stereocenters are widely present in natural products and bioactive molecules. However, the construction of such motif one step from readily available starting materials remains a significant challenge. Herein, we report phosphine‐catalyzed divergent γ,γ‐ ε,γ‐umpolung domino addition bisoxindoles with allenoates. This method serves as practical tool for concise synthesis series bisoxindole derivatives bearing sterically hindered vicinal...
A palladium-catalyzed cascade coupling between glycals and racemic α-nitroesters enables the stereoselective construction of C-glycosyl amino acids bearing two contiguous stereocenters, achieving dual stereocontrol (exclusive β-C1, up to 10:1 diastereomeric ratio at C7). This one-pot protocol room temperature accommodates diverse substrates (25 examples). Mechanistic studies demonstrate that decarboxylation-induced C4-oxyanion directs 1,4-syn selectivity, while steric modulation governs C7...
In this study, fluorescent molecularly imprinted polymers (FMIPs), which were for the selective recognition and fluorescence detection of λ-cyhalothrin (LC), synthesized via fluorescein 5(6)-isothiocyanate (FITC) 3-aminopropyltriethoxysilane (APTS)/SiO2 particles. The SiO2@FITC-APTS@MIPs characterized by Fourier transform infrared (FT-IR), UV–vis spectrophotometer (UV–vis), spectrophotometer, thermogravimetric analysis (TGA), confocal laser scanning microscope (CLSM), electron microscopy...
A red phosphor K<sub>2</sub>SiF<sub>6</sub>:Mn<sup>4+</sup>nanorod is successfully prepared through an efficient one-step method at room temperature for 30 min. Under UV excitation, K<sub>2</sub>SiF<sub>6</sub>:Mn<sup>4+</sup>nanorods show better emission corresponding to the characteristic lines of Mn<sup>4+</sup>compared bulk materials.
<h3>Importance</h3> Obesity is a public health challenge in China, but the geographical profiles of overweight and obesity among Chinese children are limited. <h3>Objective</h3> To examine regional disparities prevalence heterogeneous population adolescents to provide more accurate profile China. <h3>Design, Setting, Participants</h3> The Prevalence Risk Factors for Diabetes Youth (PRODY) study was cross-sectional survey conducted from January 1, 2017, December 31, 2019, 201 098 aged 3 18...
Developing efficacious drug delivery systems for targeted cancer chemotherapy remains a major challenge. Here we demonstrated kind of pH-responsive PEGylated doxorubicin (DOX) prodrug via the effective esterification and Schiff base reactions, which could self-assemble into biodegradable micelles in aqueous solutions. Owing to low pH values inside tumor cells, these PEG-Schiff-DOX nanoparticles exhibited high loading ability release behavior within cells or tissues upon changes physical...
A stereocontrolled synthesis of an aryl
Colorectal cancer (CRC), a common malignant tumor of the digestive tract, has high incidence and mortality rate. Several recent studies have found that aging is associated with increasing risk cancer. Nevertheless, expression status function age-related genes in CRC still not well understood. In study, we comprehensively analyzed gene data patients from The Cancer Genome Atlas (TCGA) database. Age-related differential (age-related DEGs) tissues compared normal were further identified. Gene...