A5101933120- Acute Myeloid Leukemia Research
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Curcumin's Biomedical Applications
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- CNS Lymphoma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Cell death mechanisms and regulation
- Covalent Organic Framework Applications
- Sphingolipid Metabolism and Signaling
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Circular RNAs in diseases
- Escherichia coli research studies
- melanin and skin pigmentation
- Calcium signaling and nucleotide metabolism
- Immune Cell Function and Interaction
- Glioma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Microfluidic and Bio-sensing Technologies
- Animal Nutrition and Physiology
Northwest A&F University
2025
Sichuan University
2009-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Capital Medical University
2012-2024
Ningbo University of Technology
2024
Beijing Children’s Hospital
2024
Army Medical University
2023-2024
Zhejiang University
2024
Jiangsu University of Science and Technology
2024
Xinqiao Hospital
2024
Tumor markers are beneficial for the diagnosis and therapy monitoring of lung cancer. However, value tumor in cancer histological is unknown. In this study, we analyzed serum levels six (CEA, CYFRA21-1, SCC, NSE, ProGRP, CA125) 2097 suspected patients with determined whether combination was useful We found that CYFRA21-1 most sensitive marker NSCLC. ProGRP showed a better clinical performance than NSE discriminating between SCLC The level or SCC significantly higher squamous carcinoma...
Abstract Resveratrol (3,5,4′-trihydroxy-trans-stilbene, RSV), a natural polyphenolic compound, is known as promising anti-cancer agent. In this study, we showed that RSV could inhibit the growth of B16 cells via induction apoptosis. Moreover, our results for first time induced autophagy in cells, which might occur through ceramide accumulation and Akt/mTOR pathway inhibition. Inhibition by an autophagic inhibitor 3-methyladenine (3-MA) or si-Beclin 1 enhanced RSV-induced cytotoxicity Thus,...
IGF2BP2 has been reported to serve as an oncogene in various solid cancers. However, the role of acute myelocytic leukemia (AML) is still unknown.Public databases Gene Omnibus was used evaluate expression AML patients and healthy controls. In addition, primary cells from these two populations were prepared by Ficoll density centrifugation. Rt-qPCR western blot detect populations. Meta-analysis performed association prognosis. Lentivirus-based shRNAs knock down cell lines KG-1a Kasumi.We...
Abstract Background Ovarian cancer was one of the leading causes female deaths. Patients with OC were essentially incurable and portends a poor prognosis, presumably because profound genetic heterogeneity limiting reproducible prognostic classifications. Methods We comprehensively analyzed an ovarian single-cell RNA sequencing dataset, GSE118828, identified nine major cell types. Relationship between clusters explored CellPhoneDB. A malignant epithelial cluster confirmed using pseudotime...
Chidamide, a novel histone deacetylase (HDAC) inhibitor, induces antitumor effects in various types of cancer. The present study aimed to evaluate the cytotoxic effect chidamide on multiple myeloma and underlying mechanisms involved. Viability cells upon treatment was determined by Cell Counting Kit‑8 assay. Apoptosis induction cell cycle alteration were detected flow cytometry. Specific apoptosis‑associated proteins evaluated western blot analysis. Chidamide suppressed viability time‑...
MicroRNAs (miRNAs) are posttranscriptional modulators of gene expression that play important roles in various biological processes. Spermatogenesis is a highly regulated process which diploid spermatogonia eventually differentiate into haploid spermatozoa. In this study, we identified four differentially expressed miRNAs between two premeiotic male germ cells, made predictions about their putative targets, and confirmed cyclin T2 (Ccnt2) as direct target miR‐15a. We also report miR‐15a...
Appropriate innate immune responses are required to protect an organism against foreign pathogens, and the response must be tightly controlled. Here, we report a new microRNA (miRNA) identified from small RNA library epididymis, termed miR-7578, that acts as negative regulator of inflammatory responses. It was abundantly expressed in immune-related organs induced by lipopolysaccharide lung well macrophages stimulated with diverse Toll-like receptor ligands, NF-κB-dependent manner....
Cyclin Y (CCNY) is a novel cyclin and almost nothing known about its role in human cancers. To investigate the clinical significance of serum anti-CCNY autoantibodies nonsmall-cell lung carcinoma (NSCLC), levels CCNY protein 264 patients with NSCLC, 103 tuberculosis, 89 healthy controls were analyzed by immunohistochemistry. The result shows that, compared normal tissues, NSCLC tissues contained higher protein. sera than (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Myeloid sarcoma is a type of malignant neoplasm composed myeloblasts that locates extramedullary. The present study reports the case 31-year-old female who presented with upper abdominal pain, melena, vomiting and jaundice. computed tomography revealed mass in gastric antrum area possible infiltration duodenum, gallbladder head pancreas, retroperitoneal lymph node metastasis. tumor grew quickly led to serious obstructive New masses developed bilateral orbits left breast within 2 months...
Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis, and its heterogeneity affects the response to clinical treatments. Glycolysis highly associated HCC therapy prognosis. The present study aimed identify novel biomarker for by exploring of glycolysis in HCC. intersection both marker genes glycolysis‑related cell clusters from single‑cell RNA sequencing analysis mRNA data liver Cancer Genome Atlas were used construct prognostic model through Cox proportional hazard...
Background: NL101 has shown activities against multiple myeloma and acute myeloid leukemia, but its anti-lymphoma activity remains unknown. The transcription factor c-Myc is frequently dysregulated in aggressive B cell lymphomas such as double-hit lymphoma, for which the standard of care still lacking. A novel approach to target needs be explored. Although role oncogenic microRNA-21 (miR-21) was well established an inducible mice model whether targeting miR-21 could inhibit growth lymphoma...