Abstract Cholangiocarcinoma (CCA) is a highly malignant biliary tract cancer with currently suboptimal diagnostic and prognostic approaches. We present novel system to monitor CCA using exosomal circular RNA (circRNA) via serum liquid biopsies. A pilot cohort consisting of patients CCA-induced obstruction (CCA-BO, n = 5) benign (BBO, was used identify CCA-derived circRNAs through microarray analysis. This followed by discovery ( 20) further reveal CCA-specific circRNA complex...

Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis, and its heterogeneity affects the response to clinical treatments. Glycolysis highly associated HCC therapy prognosis. The present study aimed identify novel biomarker for by exploring of glycolysis in HCC. intersection both marker genes glycolysis‑related cell clusters from single‑cell RNA sequencing analysis mRNA data liver Cancer Genome Atlas were used construct prognostic model through Cox proportional hazard...

The optimal timing of surgery after neoadjuvant chemotherapy (NAC) in patients with synchronous colorectal cancer liver metastases (SLM) remains controversial. We plan to analyze whether the choice different surgical timings will have effects on perioperative and oncologic outcomes patients.We retrospectively collected all who met inclusion exclusion criteria from 2010 2020 West China Hospital. Patients were grouped according time interval (TI) NAC surgery. two groups compared propensity...

Re-resection is recommended for patients with incidental gallbladder carcinoma (iGBC) at T1b stage and above. It unclear whether continuation of laparoscopic re-resection (CLR) intraoperatively detected iGBC (IDiGBC) more beneficial to short- long-term clinical outcomes than conversion radical extensive-resection (RER).

In the treatment of hilar cholangiocarcinoma (HCCA), combined resection important hepatic vessels remains controversial. The purpose this study was to compare postoperative complications and prognosis non-combined major vessel resections in patients undergoing radical for HCCA.In study, with HCCA who underwent curative between January 2007 December 2018 were retrospectively enrolled. Postoperative groups compared using propensity score-matching (PSM) analysis.There 310 included study. portal...

Abstract Background There was a dearth of reliable research on the clinical value combined caudate lobectomy in intrahepatic cholangiocarcinoma involving hepatic hilus. We aimed to compare short-term and long-term outcome versus non-combined patients undergoing curative-intent resection for Methods This single center retrospective cohort study with hilar conduct from January 2007 December 2021. Patients who underwent radical re-resection were enrolled. The outcomes groups compared before...

<title>Abstract</title> Background Re-resection is recommended for patients with incidental gallbladder carcinoma (iGBC) at T1b stage and above. It unclear whether continuation of laparoscopic re-resection (CLR) intraoperatively detected iGBC (ID-iGBC) more beneficial to short- long-term clinical outcomes than conversion laparotomy (COR). Methods This single-centre, retrospective cohort study was conducted between June 2006 August 2021. Patients who underwent immediate or higher ID-iGBC were...

<title>Abstract</title> <bold>Background: </bold>The association between body composition and outcomes has been established in numerous malignancies. However, the prognostic significance of cholangiocarcinoma remains unclear. This meta-analysis aims to determine value preoperative unfavorable statusin patients undergoing curative-intent surgery for cholangiocarcinoma. <bold>Methods: database searches encompassed PubMed, Embase, Web Science from their inception February 2024. The main...

<title>Abstract</title> <bold>Background: </bold>Cancer stem cells play a key role in the progression and therapy resistance of colon adenocarcinoma (COAD). In this study, we investigated identified cell-regulated genes associated with COAD prognosis by co-expression network analysis. <bold>Methods: </bold>R software was used to analyze mRNA expression stemness index (mRNAsi) COAD, differentially expressed were screened out conduct weighted gene analysis (WGCNA). Functional prognostic...

Abstract Background Obstructive jaundice is a common problem associated with diverse etiologies which has not been thoroughly investigated in large-scale cohorts. Our study involved the largest retrospective cohort of obstructive to date, exploring spectrum diseases while establishing diagnostic system machine learning (ML) methods based on routine laboratory tests. Methods This involves two observational cohorts from China. The biliary surgery (BS cohort, n=349) served for initial data...

Extended hepatectomy combined with caudate lobe resection has been approved for the radical of hilar cholangiocarcinoma. There was a lack credible research on clinical value lobectomy (CL) intrahepatic cholangiocarcinoma involving hepatic hilus when hepatectomy. We aimed to compare short-term and long-term outcomes procedure those only CL curative hilus.

Abstract Background Our previous study revealed that lnc-TSPAN12 was remarkably upregulated in HCC and correlated with poor survival. However, the role of regulating epithelial-mesenchymal transition (EMT) metastasis hepatocellular carcinoma (HCC) remains uncharacterized. Methods The biological function investigated by loss- gain-of-function experiments both vitro vivo. RNA pull-down, immunoprecipitation fluorescence situ hybridisation were performed to examine interaction between Eukaryotic...

Abstract Circular RNAs (circRNAs) have been widely reported to participate in diverse biological pathways cancers. However, the function of circRNAs hepatocellular carcinoma (HCC) remains some unclear. In present study, we screened expression profile HCC and identified that circYTHDF3 (hsa_circ_0084620) was dramatically upregulated tissues cell lines. Patients with high-expression performed a poor prognosis. CircYTHDF3 could facilitate proliferation, migration, invasion cell. Furthermore,...

Abstract Background: The optimal timing of surgery after neoadjuvant chemotherapy (NAC) in patients with synchronous colorectal cancer liver metastases (SLM) remains controversial. We plan to analyze whether the choice different surgical timings will have effects on perioperative and oncologic outcomes patients. Method: retrospectively collected all who met inclusion exclusion criteria from 2010 2020 west china hospital . Patients were grouped according time interval (TI) NAC surgery. two...

Abstract In a previous study, we discovered that the lnc-TSPAN12 level was significantly elevated in hepatocellular carcinoma (HCC) and linked to low chance of survival. HCC, however, function modulating epithelial-mesenchymal transition (EMT) metastasis is still poorly understood. This study demonstrated positively modulated migration, invasion, EMT HCC cells vitro exacerbated hepatic patient-derived tumour xenograft metastatic models vivo. The modification N6-methyladenosine driven by...

Abstract Background Perihilar cholangiocarcinoma (pCCA) is the most common malignancy of biliary tree. Resection only potentially curative treatment for pCCA. Systemic inflammation and nutrition status are sources important prognostic factors patients with In this study, a risk score, named “neutrophil-albumin-bilirubin (NAB)”, was developed validated based on biomarkers Methods A total 161 who underwent surgical resection between December 2008 to April 2016 were included in retrospective...

Abstract Background Sorafenib remains the cornerstone chemotherapeutic treatment for patients with late-stage hepatocellular carcinoma (HCC). Unfortunately, resistance to this drug in context of disease is frequent, and underlying mechanisms remain unclear. In regard, exosome-contained noncoding RNAs (ncRNAs) have been proven participate various diseases. Here, we aimed identify exosomal circular RNA (circRNA)-mediated mechanism by which sorafenib develops HCC. Methods Differential...