A5101943651- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Dark Matter and Cosmic Phenomena
- Solar and Space Plasma Dynamics
- Cancer-related gene regulation
- Astrophysics and Cosmic Phenomena
- Peroxisome Proliferator-Activated Receptors
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiation Therapy and Dosimetry
- Atmospheric Ozone and Climate
- Nuts composition and effects
- Extracellular vesicles in disease
- Inflammatory Biomarkers in Disease Prognosis
- Intraperitoneal and Appendiceal Malignancies
- Quantum Electrodynamics and Casimir Effect
- CNS Lymphoma Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Tissue Engineering and Regenerative Medicine
- Water Quality Monitoring and Analysis
- TGF-β signaling in diseases
- Caveolin-1 and cellular processes
- Genetic and Kidney Cyst Diseases
- Analytical Chemistry and Sensors
Zhejiang University
2023-2025
Sichuan University
2010-2024
West China Hospital of Sichuan University
2012-2024
Zhejiang University-University of Edinburgh Institute
2024
Abstract Cholangiocarcinoma (CCA) is a highly malignant biliary tract cancer with currently suboptimal diagnostic and prognostic approaches. We present novel system to monitor CCA using exosomal circular RNA (circRNA) via serum liquid biopsies. A pilot cohort consisting of patients CCA-induced obstruction (CCA-BO, n = 5) benign (BBO, was used identify CCA-derived circRNAs through microarray analysis. This followed by discovery ( 20) further reveal CCA-specific circRNA complex...
Pancreatic cancer is one of the most lethal malignant diseases with poorest prognosis and fourth leading cause tumor‑associated mortality in industrialized world. microRNAs (miRNAs or miRs) are small noncoding RNAs approximately 22 nucleotides long that able to function as oncogenes tumor suppressors human cancer. In our study, overexpression miR‑203 Panc‑1 cells sufficient reduce migratory ability invasiveness, induce upregulation epithelial markers (Snail, ZO‑1 β‑catenin) followed by a...
Mitochondrial trans-2-enoyl-CoA reductase (MECR) is a protein-coding gene, and the protein encoded by this gene an oxidoreductase that catalyzes last step in mitochondrial fatty acid synthesis (mtFASII). Numerous studies have shown disorder of lipid metabolism closely related with malignance, especially liver cancer. Through pre-experiment, we found expression MECR was highly expressed hepatocelluar carcinoma (HCC) cell lines vitro. This suggests may play role oncogene HCC. Therefore,...
Emerging evidence demonstrates that abnormally expressed long noncoding RNAs (lncRNAs) are involved in the progression of various cancers. However, expression profiles and functions lncRNAs hepatocellular carcinoma (HCC) with microvascular invasion (MVI) remain largely unknown. In this study, we revealed differential lncRNA messenger RNA four pairs HCC MVI adjacent nontumor liver tissues by using high-throughput sequencing. Among these dysregulated lncRNAs, lnc-TSPAN12 was most significantly...
Extranodal lymphoma occurs in ~40% of all patients with and has been described virtually organs tissue. However, diffuse large B-cell (DLBCL), which is the most common histological subtype non-Hodgkin's (NHL), primarily arising retroperitoneal region rarely reported. Primary without renal or ureteral involvement affecting genitourinary system not reported until now. In this article, we report rare case a young female suffering primary DLBCL located simultaneously gastrointestinal region. The...
Abstract Background Our previous study revealed that lnc-TSPAN12 was remarkably upregulated in HCC and correlated with poor survival. However, the role of regulating epithelial-mesenchymal transition (EMT) metastasis hepatocellular carcinoma (HCC) remains uncharacterized. Methods The biological function investigated by loss- gain-of-function experiments both vitro vivo. RNA pull-down, immunoprecipitation fluorescence situ hybridisation were performed to examine interaction between Eukaryotic...
Abstract In a previous study, we discovered that the lnc-TSPAN12 level was significantly elevated in hepatocellular carcinoma (HCC) and linked to low chance of survival. HCC, however, function modulating epithelial-mesenchymal transition (EMT) metastasis is still poorly understood. This study demonstrated positively modulated migration, invasion, EMT HCC cells vitro exacerbated hepatic patient-derived tumour xenograft metastatic models vivo. The modification N6-methyladenosine driven by...
Abstract Background Sorafenib remains the cornerstone chemotherapeutic treatment for patients with late-stage hepatocellular carcinoma (HCC). Unfortunately, resistance to this drug in context of disease is frequent, and underlying mechanisms remain unclear. In regard, exosome-contained noncoding RNAs (ncRNAs) have been proven participate various diseases. Here, we aimed identify exosomal circular RNA (circRNA)-mediated mechanism by which sorafenib develops HCC. Methods Differential...
Jiang, X. Q.; Zhang, J.; Cheng, N.; Xiong, Z.; Chen, Y.; lu, Y. R.; cheng, J. Q. Author Information
Abstract Background: The prognosis of hepatocellular carcinoma (HCC) is bleak though it has been improved over recent years. Early diagnosis could improve the survival. Plenty researches indicate that long non-coding RNAs (lncRNAs) play an important role in prognostic prediction cancer as a kind biomarker. Methods: We downloaded clinicopathological characteristics and lncRNA expression data HCC patients from Cancer Genome Atlas (TCGA) database. ratio training sets to validation was 2:1....
Abstract Background : The prognosis of hepatocellular carcinoma (HCC) is bleak though it has been improved over recent years. Early diagnosis could improve the survival. Plenty researches indicate that long non-coding RNAs (lncRNAs) play an important role in prognostic prediction cancer as a kind biomarker. Results We identified and validated ten-lncRNAs based signatures to predict disease-free survival (DFS) overall (OS) HCC respectively from lncRNA expression data patients Cancer Genome...